From: The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges
Shuttle | Expression | Target | Species/Cells | Functions | References | |
---|---|---|---|---|---|---|
Invasion | miR-155 | ↓ | HMGN2 | Human/A549, HBE16 | Promoting the function of integrin α5β1 Increasing the polymerization of actin Regulating the adhesion of bacteria | [59] |
miR-23a | ↓ | HMGN2 | Human/A549, HBE16 | Modulating the expression of integrin α5β1 Regulating the adhesion of bacteria | [59] | |
miR-223-3p | ↑ | CagA | Human/AGS | Regulating the colonization of bacteria Increasing the cell proliferation and migration | [60] | |
miR-223-3p | ↑ | NLRP3 | Human/THP-1 | Mediating the concentration of bacteria Adjusting inflammasome function and responses | [62] | |
Virulence | miR-155 | ↑ | PepO | Mice/PEMs | Enhancing the phagocytosis of macrophages Promoting host defense response to bacteria | [67] |
miR-147-3p | ↓ | Esx-1 | Mice/RAW264.7 | Increasing the survival rate of bacteria | [69] | |
miR-155 | ↑ | Rv2346c | Human/U937 Mice/RAW264.7 | Increasing the bacterial load and lung injury Enhancing the secretion of virulence factor | [71] | |
miR-99b | ↑ | Rv2346c | Human/U937 Mice/RAW264.7 | Increasing the bacterial load and lung injury Enhancing the secretion of virulence factor | [71] | |
Immune escape | miR-325-3p | ↑ | LNX1 | Mice/RAW264.7 | Inhibiting the process of apoptosis Promoting the intracellular survival of bacteria | [77] |
miR-466 | ↑ | TIRAP | Human/MSCs Mice/RAW264.7 | Promoting macrophage polarization toward Type 2 phenotype | [78] |