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Table 2 miRNAs involved in impeding the pathogen to induce host infection

From: The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges

 

Shuttle

Expression

Target

Species/Cells

Functions

References

Invasion

miR-155

HMGN2

Human/A549, HBE16

Promoting the function of integrin α5β1

Increasing the polymerization of actin

Regulating the adhesion of bacteria

[59]

miR-23a

HMGN2

Human/A549, HBE16

Modulating the expression of integrin α5β1

Regulating the adhesion of bacteria

[59]

miR-223-3p

CagA

Human/AGS

Regulating the colonization of bacteria

Increasing the cell proliferation and migration

[60]

miR-223-3p

NLRP3

Human/THP-1

Mediating the concentration of bacteria

Adjusting inflammasome function and responses

[62]

Virulence

miR-155

PepO

Mice/PEMs

Enhancing the phagocytosis of macrophages

Promoting host defense response to bacteria

[67]

miR-147-3p

Esx-1

Mice/RAW264.7

Increasing the survival rate of bacteria

[69]

miR-155

Rv2346c

Human/U937

Mice/RAW264.7

Increasing the bacterial load and lung injury

Enhancing the secretion of virulence factor

[71]

miR-99b

Rv2346c

Human/U937

Mice/RAW264.7

Increasing the bacterial load and lung injury

Enhancing the secretion of virulence factor

[71]

Immune escape

miR-325-3p

LNX1

Mice/RAW264.7

Inhibiting the process of apoptosis

Promoting the intracellular survival of bacteria

[77]

miR-466

TIRAP

Human/MSCs

Mice/RAW264.7

Promoting macrophage polarization toward Type 2 phenotype

[78]

  1. “↑” increased; “↓” decreased