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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p

Fig. 6

circ_0086296 acts as a miR-576-3p sponge to regulate IFIT1 levels. A, B Relative protein expression was measured in HUVECs treated with ox-LDL. **p < 0.001 versus sham group. C, D Relative protein expression was measured in HUVECs infected with sh-circ_0086296 vector and overexpressed IFIT1 vector. **p < 0.001 versus shNC group, #p < 0.05, ##p < 0.001 versus the shcirc group. E Viability of HUVECs infected with sh-circ_0086296 and overexpressed IFIT1 vector via CCK-8 assay. F, G Detection of migration potential of HUVECs infected with sh-circ_0086296 and overexpressed IFIT1 vector. **p < 0.001 versus sham group, ##p < 0.001 versus the relative control group. H, I Detection of the vasculogenic capacity of HUVECs infected with sh-circ_0086296 and overexpressed IFIT1 vector. **p < 0.001 versus sham group, ##p < 0.001 versus the relative control group. J The colocalization of circ_0086296 and IFIT1 was measured in plaque tissues via fluorescence in situ hybridization (FISH). K IF staining displayed IFIT1 expression in HUVECs infected with sh-circ_0086296, and miR-576-3p inhibitor

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