Fig. 8

circ_0086296 causes the atherosclerotic phenotype in vivo. A Atherosclerotic mice were injected with sh-circ_008629, and the mice aortas were visualized with en face Oil Red O staining. B Relative circ_0086296 levels were detected in atherosclerotic mice injected with sh-circ_008629 or sh-NC. C Relative miR-576-3p levels were detected in atherosclerotic mice injected with sh-circ_008629 or sh-NC. D Relative IFIT1, STAT1, STING, p-STAT1, p-NF-κB, and pIRF3 levels were detected in atherosclerotic mice injected with sh-circ_008629 or sh-NC. E Quantification of D. F–I The levels of total cholesterol, triglyceride, and LDL-C were decreased and HDL-C was increased in atherosclerotic mice injected with sh-circ_008629. J, K Illustrative en face Oil Red O staining in atherosclerotic mice injected with sh-circ_008629 or sh-NC aorta. L, M Illustrative hematoxylin and eosin staining in atherosclerotic mice injected with sh-circ_008629 or sh-NC aorta. N, O Illustrative Masson staining in atherosclerotic mice injected with sh-circ_008629 or sh-NC aorta. P Immunohistochemical staining of CD31 in atherosclerotic mice injected with sh-circ_008629 or sh-NC aorta. Q Immunohistochemical staining of IFIT1 in atherosclerotic mice injected with sh-circ_008629 or sh-NC aorta. R Immunofluorescence staining of IFIT1 in atherosclerotic mice injected with sh-circ_008629 or sh-NC aorta. **p < 0.001 versus shNC group