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Table 1 Exosomal miRNAs in B-CLL

From: Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid

mRNAs

Expression

in CLL

Target

Function

Oncogenic or Suppressive

Refs.

miR-202-3p

Upregulated

Sufu gene

‘suppressing fused’ (Sufu) is targeted by gene of miR-202-3p

increase, modulator of the Gli Hedgehog signaling pathway

-During development, it is thought to be involved in pattern formation and cellular proliferation.

- decreasing in the intracellular level of this miRNA causes an increase in the expression level of Sufu, which aids tumor cell survival and progression.

Oncogene

[69, 71]

miR-146a/miR-451

Upregulated

Kinases in Stromal cells

inducing the stromal cells activation by phosphorylation of several kinases

Oncogene

[69, 71, 75]

miR-150

Upregulated

c-Myb

playing an important role in the process of hematopoiesis, particularly in the development of lymphoid lineage

Oncogene

[69, 71]

miR-19b

Upregulated

TP53 and MKI67

TP53 downregulation and MKI67 upregulation as tumor cell proliferation, survival, and invasion mechanisms

Oncogene

[69, 76]

miR-155

Upregulated

SHIP1

In CLL, it has an oncogenic role; it promotes the BCR response by targeting SHIP1.

Oncogene

[69, 71]

miR-29

Downregulated

TCL1

regulation of TCL1, MCL1 and

DNA-methyltransferases

Tumor suppressor

function in aggressive

CLLs (downregulated

versus

indolent CLL)

[69, 71]

miR-223

Downregulated

HSPs

HSP90B1

Oncogene

[69, 77, 78]

Y RNA

Upregulated

 

it is overexpressed in tumors and is essential for cell proliferation

Oncogene

[69, 79]