Table 2 Exosomal miRNAs associating in CML and AML
miRNA | Malignancy | Alteration mode | Function/description | Refs. |
|---|---|---|---|---|
Pre-miR-92a | CML | Increased | Down-regulating the integrin a5 and improving endothelial the cell movement and tube formation. | [100] |
miR-210 | CML | Increased | Interacting with Ephrin-A3 and playing a vital role in angiogenesis and VEGF signaling. | [101] |
miR365 | CML | Increased | Drug resistance by preventing the production of pro-apoptosis proteins. | [105] |
miR-150, miR-155 and miR-1246 | AML | Increased | Their high serum levels lead to considering them as minimally-invasive early biomarker of AML. promoting the apoptosis and differentiation of LSCs through inactivation of STAT3 pathway. | [109] |
miR-425-5p | AML | Decreased | Inhibiting cell viability, invasion and migration via inducing apoptosis genes of AML cells such as cleaved PARP, cleaved caspase3 and Wilms tumor 1-associated protein (WTAP). | [110] |
miR-21 and miR-29 | AML | Increased | Promoting the survival of healthy hematopoietic stem cells and inducing leukemia-like functional features in them |