Table 3 Exosomal mRNA as biomarkers in MS
mRNA | Source of exosomes | Function | Refs. |
|---|---|---|---|
miR-326 | Conventional T cells | differentiation and maturation of Th17 | [136] |
let-7i | Plasma | inhibit the initiation of regulatory T cells | [157] |
miR-15b-5p | Serum | Targets FGF-2 implicated in Demyelination and remyelination | [158] |
miR-451a | Serum | Regulator of oxidative stress | [158] |
miR-30b-5p | Serum | Neuro-axonal injury | [158] |
miR-342-3p | Serum | Neuro-axonal injury | [158] |
miR-122-5p,miR-196b-5p,miR-301a-3p,miR-532-5b | Serum | Targets STAT3 and AHR, differentiation and regulation of Th17 | [159] |