Fig. 7

miR-92a-2-5p modulated the p38-MAPK pathway by inhibiting MKNK2 expression. A Relative expression level of miR-92a-2-5p in rat heart tissues from the NC and miR-92a-2-5p agomiR groups. ** P < 0.01. B Representative images of immunohistochemistry (IHC) for MKNK2 in rat left ventricle tissues from the NC and miR-92a-2-5p agomiR groups. Scale bar = 100 μm. C Representative images of western blot for MKNK2 and p38 proteins in NC and miR-92a-2-5p agomiR groups. D, E Integrated density analysis of immune bands using ImageJ software. β-actin was used as a loading control. n = 10 in each group. **P < 0.01. F Representative images of western blot for MKNK2 and p38 proteins in cardiomyocytes infected with Ad-miR-92a-2-5p under high glucose stimulation. G Integrated density analysis of immune bands using ImageJ software. β-Aactin was used as a loading control. n = 3 in each group. **P < 0.01