Fig. 4

Single-cell analysis of COX4I2 based on single-cell RNA sequencing dataset CRC-016-01-1A. a Cellular components. b UMAP plots showing different CRC cell types after quality control, reduction of dimensionality, and clustering. c UMAP plots showing expression of COX4I2 clusters. d Violin plots of CRC cell cluster markers and COX4I2 in various cell types. Expression was measured as log 2 (TP10K + 1). e–g Functional enrichment analysis. h–j Enrichment scores of genes from the Hallmark hypoxia gene set for each cell, from the gene set variation analysis: h HALLMARK_HYPOXIA, i EPITHELIAL_MESENCHYMAL_TRANSITION, j ANGIOGENESIS. For Abbreviations, see Abbreviation list