Fig. 6

Overexpression of COX4I2 promotes CRC cell invasion and metastasis by affecting the EMT. a Cell invasion (Transwell assay) (magnification: × 200, scale bars: 50 μm). b Cell migration (scratch assay) (magnification: × 200, scale bars: 50 μm). c Correlations between COX4I2 and EMT-related genes, from TIMER. d EMT-related proteins shown by western blotting (n = 3 replicates). Data are expressed as mean ± SEM. Asterisks indicate significant difference at *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. All experiments were repeated at least three times, independently. For abbreviations, see Abbreviation List