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Fig. 1. | Cellular & Molecular Biology Letters

Fig. 1.

From: 5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo

Fig. 1.

5-MF administration protected mice against IAV-induced lung injury. A Chemical structure of 5-MF. BF Mice were intragastrically administered 5-MF (20, 40 mg·kg−1·d−1) 2 days prior to intranasal inoculation of 5LD50 of mouse-adapted H1N1 virus. B, C On day 5 post-infection (p.i.), the whole lung gross morphology of the mice was examined (B), and the lung index (n = 5) (lung/body weight ratio) was determined (C). D On day 7 p.i., histopathological changes of the lungs were examined by H&E staining. E Lung injury score was recorded according to the lung histopathology changes. F The survival rate of mice was observed and recorded for 15 consecutive days. ##p < 0.01 relative to the control group; *p < 0.05 relative to the virus group

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