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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: lncRNA PVT1: a novel oncogene in multiple cancers

Fig. 7

The role of PVT1 in the immune system. A PVT1 can activate CD4+ T cells. B PVT1 can promote autophagy of regulatory T cells by targeting miR-146a. C PVT1 can promote the expression of HMGB1 and promote the polarization of M1 macrophages by targeting miR-29a. D PVT1 can reduce TH17 differentiation by attenuating NOTCH1 expression. E PVT1 can promote the effect of MDSCs to achieve tumor immune suppression

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