Table 1 Functional characterization of PVT1 in respiratory system tumors
Tumor type | Expression | Role | Function role | miRNAs | Related genes | References |
|---|---|---|---|---|---|---|
Nasopharyngeal carcinoma | Upregulation | Oncogene | Proliferation | miR-1207 | PI3K/AKT | [54] |
Nasopharyngeal carcinoma | Upregulation | Oncogene | Proliferation and radioresistance | miR-515-5p | PIK3CA | [55] |
Lung cancer | Upregulation | Oncogene | Proliferation | / | P15/P21 | [6] |
Lung cancer | Upregulation | Oncogene | Invasion and proliferation | miR-497 | / | [56] |
Lung cancer | Upregulation | Oncogene | Proliferation | / | LATS2 | [42] |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and EMT | miR-497 | YAP1 | [57] |
Lung cancer | Upregulation | Oncogene | Proliferation and migration | miR-526b | EZH2 | [58] |
Lung cancer | Upregulation | Oncogene | Invasion | miR-200a/200b | MMP9 | [59] |
Lung cancer | Upregulation | Oncogene | Proliferation | miR-199a-5p | HIF-1α | [60] |
Lung cancer | Upregulation | Oncogene | Angiogenesis | miR-29c | VEGF | [61] |
Lung cancer | Upregulation | Oncogene | Proliferation and metastasis | miR-128 | VEGFC | [62] |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, and invasion | miR-361-3p | SOX9 | [63] |
Lung cancer | Upregulation | Oncogene | Migration and invasion | miR-760 | IL-6 | [64] |
Lung cancer | Upregulation | Oncogene | Proliferation | miR-17-5p | BAMBI | [65] |
Lung cancer | Upregulation | Oncogene | Proliferation and migration | miR-148 | RAB34 | [66] |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, and invasion | miR-551b | FGFR1 | [67] |
Lung cancer | Upregulation | Oncogene | Invasion and growth | miR-378c | SLC2A1 | [68] |
Lung cancer | Upregulation | Oncogene | Radioresistance | miR-195 | / | [69] |
Lung cancer | Upregulation | Oncogene | Radioresistance | miR-424-5p | CARM1 | [70] |
Lung cancer | Upregulation | Oncogene | Cisplatin-resistance | miR-181a-5p | SP1 | [71] |
Lung cancer | Upregulation | Oncogene | Cisplatin-resistance | miR-216b | Beclin-1 | [72] |