Table 4 Main characteristics of the studies included in the review of digestive system tumors
Study | Tumor type | Sample size (normal: tumor) | Detection method | P value | TNM (P value) | LNM (P value) | DM (P value) | OS (P value) | DFS (P value) | References |
|---|---|---|---|---|---|---|---|---|---|---|
Li | Oral squamous cell carcinoma | 70:70 | qRT-PCR | < 0.01 | < 0.05 | / | < 0.01 | / | / | [9] |
Zheng | Esophageal cancer | 77:77 | qRT-PCR | 0.002 | 0.009 | / | / | / | / | [77] |
Li | Esophageal cancer | 104:104 | qRT-PCR | 0.024 | 0.001 | 0.597 | / | 0.005 | 0.011 | [78] |
Xu | Gastric cancer | 190:190 | qRT-PCR | < 0.001 | / | / | / | / | / | [84] |
Huang | Gastric cancer | 68:68 | qRT-PCR | < 0.05 | 0.022 | 0.005 | / | / | / | [85] |
Li | Gastric cancer | 20:20 | qRT-PCR | 0.0004 | / | / | / | / | / | [86] |
Wang | Gastric cancer | 42:42 | qRT-PCR | < 0.01 | < 0.05 | < 0.01 | / | / | / | [87] |
Ding | Liver cancer | 58:58 | qRT-PCR | 0.042 | < 0.05 | / | / | / | 0.021 | [12] |
Wang | Liver cancer | 89:89 | qRT-PCR | < 0.05 | 0.007 | / | / | 0.0104 | 0.0043 | [92] |
Gou | Liver cancer | 92:92 | qRT-PCR | < 0.05 | < 0.05 | / | / | / | / | [44] |
Guo | Liver cancer | 121:121 | qRT-PCR | < 0.05 | 0.010 | / | / | / | / | [95] |
Lan | Liver cancer | 48:48 | qRT-PCR | < 0.001 | < 0.05 | / | / | 0.035 | / | [98] |
Yang | Liver cancer | 80:80 | qRT-PCR | < 0.05 | 0.041 | / | / | / | / | [101] |
Jin | Gallbladder cancer | 55:55 | qRT-PCR | < 0.001 | < 0.011 | < 0.032 | / | < 0.001 | / | [13] |
Chen | Gallbladder cancer | 20:20 | qRT-PCR | < 0.05 | < 0.001 | / | 0.047 | < 0.05 | / | [105] |
Wu | Pancreatic cancer | 30:20 | qRT-PCR | < 0.01 | < 0.05 | < 0.05 | / | / | / | [109] |
Zhao | Pancreatic cancer | 34:34 | qRT-PCR | < 0.05 | 0.038 | / | 0.000 | / | / | [110] |
Sun | Pancreatic cancer | 30:30 | qRT-PCR | < 0.001 | 0.05 | 0.004 | / | / | / | [111] |
Huang | Pancreatic cancer | 68:68 | qRT-PCR | < 0.001 | < 0.05 | / | / | < 0.05 | / | [113] |
Zeng | Colorectal cancer | 70:70 | qRT-PCR | < 0.001 | 0.029 | 0.014 | / | / | / | [126] |
Wu | Colorectal cancer | 72:72 | qRT-PCR | < 0.05 | < 0.05 | < 0.01 | < 0.05 | / | / | [127] |
Chai | Colorectal cancer | 20:20 | qRT-PCR | < 0.001 | / | / | / | / | / | [129] |
Yu | Colorectal cancer | 60:60 | qRT-PCR | < 0.05 | 0.040 | 0.006 | / | / | < 0.05 | [130] |
Liu | Colorectal cancer | 62:62 | qRT-PCR | < 0.05 | 0.0001 | 0.005 | 0.002 | / | / | [133] |
Ping | Colorectal cancer | 112:112 | qRT-PCR | < 0.05 | 0.001 | 0.015 | 0.007 | / | / | [136] |