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Table 9 Functional characterization of PVT1 in immune system

From: lncRNA PVT1: a novel oncogene in multiple cancers

Disease type

Expression

Role

Function role

miRNAs

Related genes

References

Sjogren’s syndrome

Upregulation

Pathogenic factor

Activate CD4+ T cells

/

/

[196]

Heart transplant rejection

Downregulation

Protection factor

Regulation of autophagy in regulatory T cells

miR-146a

/

[197]

Infectious myocardial injury

Upregulation

Pathogenic factor

Promote macrophage polarization

miR-29a

HMGB1

[198]

Immune thrombocytopenia

Downregulation

Protection factor

Downregulation of Th17 cell differentiation

/

NOTCH1

[199]

Tumor immune suppression

Upregulation

Pathogenic factor

Enhancing the function of MDSCs

/

/

[200]