Disease type | Expression | Role | Function role | miRNAs | Related genes | References |
---|---|---|---|---|---|---|
Sjogren’s syndrome | Upregulation | Pathogenic factor | Activate CD4+ T cells | / | / | [196] |
Heart transplant rejection | Downregulation | Protection factor | Regulation of autophagy in regulatory T cells | miR-146a | / | [197] |
Infectious myocardial injury | Upregulation | Pathogenic factor | Promote macrophage polarization | miR-29a | HMGB1 | [198] |
Immune thrombocytopenia | Downregulation | Protection factor | Downregulation of Th17 cell differentiation | / | NOTCH1 | [199] |
Tumor immune suppression | Upregulation | Pathogenic factor | Enhancing the function of MDSCs | / | / | [200] |