Fig. 3

The prognostic significance of miR‑103a in patients with HCC and miR-103a-3p promotes HCC cells proliferation. A Expression of miR-103a-3p in 369 hepatocellular carcinoma (HCC) tumor samples versus 49 normal liver tissues. Data were obtained from TCGA and log2(TPM + 1) was used to present expression level. TPM, transcripts per million reads. B Expression of miR-103a-3p in a cohort of HCC patients with different cancer stages. C Overall survival was compared between patients with HCC with a high expression level of miR-103a and those with a low level of miR-103a. D RT-qPCR analysis of miR-103a-3p levels in L02 cells and HCC cell lines. ***P < 0.001 vs L02 group. E–L Hccl-M3 and QGY-7703 cells were transfected with miR-103a-3p mimics or mimics control, miR-103a-3p inhibitor or inhibitor control, and then subjected to colony formation assays (E–K) or CCK-8 assay (I–L). Data are presented as means ± SD of three independent experiments. **P < 0.01, ***P < 0.001