Fig. 9

Schematic representation of a model depicting the underlying molecular mechanisms of the miR-103a-3p /EVA1A/TP53 regulatory axis in HCC. The increased expression of miR-103a-3p of human hepatocyte targets EVA1A mRNA and inhibits its expression, resulting in a decline of TP53 and BAX (pro-apoptotic protein), an increase of BCL-2(anti-apoptotic protein), and repression of MOMP, thereby inhibiting cell apoptosis and causing the tumor suppressor effect of EVA1A to be weakened. MOMP, mitochondrial outer membrane permeabilization