Fig. 4
From: Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway
Bioinformatic analysis of WT and DNAJB11-knockdown transcriptomic sequencing identifies DNAJB11 as a regulator of glycolytic function. A–D Gene Ontology (GO) functional classification and subcellular functional annotation of DEGs (837 upregulated genes in WT and 1499 downregulated genes in DNAJB11-knockdown cell). A GO of upregulated genes. C GO analysis of top ten upregulated genes. B GO of downregulated genes. D GO analysis of top ten downregulated genes. E KEGG pathway analysis of top ten upregulated genes. F KEGG analysis of top ten downregulated genes. G Glycolysis was inhibited in the DNAJB11-knockdown groups using the analysis of Gene Set Enrichment Analysis (GSEA). H–I The glycolytic function was measured by Seahorse XF96 and indicated that DNAJB11 is involved in glycolysis. ***P < 0.001