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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: E2F1 promotes cell cycle progression by stabilizing spindle fiber in colorectal cancer cells

Fig. 3

E2F1 transactivates stathmin1 and TACC3 in CRC cells. A Schematic representations of the promoter regions of human STMN1 and TACC3. The predicted E2F1 binding sites are indicated. B Agarose gel electrophoresis of ChIP-PCR products in the input, IgG, and ChIP groups, showing that E2F1 interacted with the STMN1 promoter at P3, and with the TACC3 promoter at P2/P3. C Quantitative PCR analysis of the efficiency of interaction of E2F1 DNA at the promoter sites shown in B. D Luciferase activities of DLD1 cells transfected with pGP4.19 promoters carrying wild-type and mutant binding sites promoter, pRL-TK and vector/E2F1

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