Fig. 1From: Downregulation of exosomal miR-7-5p promotes breast cancer migration and invasion by targeting RYK and participating in the atypical WNT signalling pathwayExosomes from highly invasive breast cancers are more likely to promote cancer cell migration than less invasive ones. A Transmission electron microscopy of exosomes extracted from MDA-MB-231 and MCF7 breast cancer cell lines. Scale bar, 200 nm. B Particle size distribution of isolated exosomes. C Western blot analysis of Alix, TSG101 and CD63, marker proteins of exosomes isolated from MDA-MB-231 and MCF7 cells. D Exosomes were labelled using Dio stain and co-incubated with MCF7 and MDA-MB-231 cells for 3 h. Scale bar, 10 μm. E Wound healing experiments with MCF7 and MDA-MB-231 cells treated with MDA-MB-231 exosomes and MCF7 exosomes, respectively. Data are presented as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001Back to article page