Fig. 1
From: Targeting UBR5 in hepatocellular carcinoma cells and precise treatment via echinacoside nanodelivery
UBR5 genomic amplification is prevalent in HCC and is linked to poor prognosis. A CNV analysis of UBR family genes in patients with HCC from the TCGA database. B Overall survival of patients with HCC from the TCGA database. C UBR5 mRNA levels in patients with HCC with UBR5 CNVs from the TCGA database. D UBR5 mRNA levels in HCC tissues and paired normal liver tissue (n = 25) from cohort 1 was measured by qRT-PCR. E Statistical analysis of UBR5 copy number in cohorts 1 and 2. F, G Survival outcomes of patients with HCC with or without UBR5 amplification in cohorts 1 and 2. H IHC was used to characterize UBR5 expression in HCC (n = 250) and normal liver (n = 30) tissue in cohort 2. Scale bar, 100 μm. I Survival outcome of patients with HCC with high or low UBR5 expression in cohort 2. J Multivariate regression analysis was performed in cohort 2. ***P < 0.001 compared with N. N normal liver tissues; T HCC tissues