Fig. 7

Targeting UCK2 could enhance the sensitive of tumour cell to T-cell-mediated killing. A Correlation of UCK2 with ESTIMATE scores and tumour purity. B Correlation between UCK2 and IPS scores. C Gene expression of UCK2 in immunotherapeutic response versus non-response group from TIDE. D Correlation between SASP and immune cell infiltrating derived from CIBFERSORT. E Gene expression of B2M, HLA-B and HLA-E in the indicated cell lines. F GSEA revealed the level of inflammasomes in the indicated cell lines. G Gene expression of NLRP1, CASP1, IL1B and IL18 in the indicated cell lines. H Different expression genes enriched in KEGG signalling pathways. I Correlation between TIDE score and metabolism related signalling pathways. J Downregulated UCK2 induced metabolism altered in immunotherapeutic response versus non-response group from TIDE; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001