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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression

Fig. 4

M1 macrophages-derived exosomes inhibited the nuclear export of circFUT8. A–C CircFUT8, miR-552-3p, and CHMP4B expression in HCC cells treated with M1-Exo or control was tested via RT–qPCR. D The effect of M1-Exo on the luciferase activity of CHMP4B promoter region in HCC cells. E, F RIP assay was adopted to assess CHMP4B and circFUT8 enrichment after HCC cells were treated with M1-Exo. G, H CircFUT8 distribution in HCC cells treated with M1-Exo or control was determined by nucleus–cytoplasmic separation and FISH assays. In C and B, data in the experimental group had statistical significance, with P < 0.01

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