Fig. 5

A–F Density of distance between gene regulatory features and heterochromatic states around TAD boundaries. To explore epigenetic mechanisms, enrichment of regulatory elements and motifs from various cell types that have previously been profiled by the Encyclopedia of DNA Elements (ENCODE) consortium and the Roadmap Epigenome project, which are involved in DNA methylation, chromatin remodeling, regulation by noncoding RNAs, and binding of regulatory proteins, and that include A 11-zinc finger protein (CTCF), B enhancers, C H3K27ac, D H3K4me1, E H3K4me3, and F H2az, was analyzed around the TAD boundaries. G–L Density of distance between gene regulatory features and TAD boundary. To explore epigenetic mechanisms, enrichment of regulatory elements and motifs from various cell types, which had previously been profiled by the Encyclopedia of DNA Elements (ENCODE) consortium and the Roadmap Epigenome project and which included G H3K27me3, H Pol2b, I H3K9ac, J TFBS, K H3K79me2, and L H4K20me1, was analyzed around the TAD boundaries