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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling

Fig. 3

Activins facilitate TGFβ1 receptor type II upregulation in response to TGFβ1 in MC. a Follistatin (FST) inhibits the TGFβ1-induced increase in TRII expression at 24 h in whole cell lysate (n = 10–11). b The TGFβ1-induced increase in cell surface TRII was diminished by follistatin at 24 h (n = 3). c No change in response to either TGFβ1 or follistatin were seen with TRI (n = 6). d The TGFβ1-induced increase in TRII transcript was also diminished by follistatin at 24 h (n = 13–15). e TGFβ1 induction of TRII expression is reduced with an actA neutralizing antibody (n = 6). *, **, ***, ****P < 0.05, 0.01, 0.001, 0.0001; one-way ANOVA with Tukey’s multiple comparisons post hoc test

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