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  1. Protein kinase B (PKB/Akt) is a serine-threonine kinase functioning downstream of phosphatidylinositol 3-kinase (PI-3 kinase) in response to mitogen or growth factor stimulation. In several cell types, it play...

    Authors: Bing Zhang and Chun Xia
    Citation: Cellular & Molecular Biology Letters 2009 14:466
  2. We developed a new targeted cationic nanoparticulate system composed of poly(D,L-lactic-co-glycolic acid) (PLGA), 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP) and asialofetuin (AF), and found it to be a ...

    Authors: Sonsoles Díez, Itziar Miguéliz and Conchita Tros de Ilarduya
    Citation: Cellular & Molecular Biology Letters 2009 14:347
  3. The expression of transmembrane transporter multidrug resistance-associated protein 1 (MRP1) confers the multidrug-resistant phenotype (MDR) on cancer cells. Since the activity of the other MDR transporter, P-...

    Authors: Olga Wesołowska, Andrzej B. Hendrich, Barbara Łania-Pietrzak, Jerzy Wiśniewski, Joseph Molnar, Imre Ocsovszki and Krystyna Michalak
    Citation: Cellular & Molecular Biology Letters 2008 14:199
  4. Gangliosides are characteristically enriched in various membrane domains that can be isolated as low density membrane fraction insoluble in detergents (detergent-resistant membranes, DRMs) or obtained after ho...

    Authors: Mirosława Panasiewicz, Hanna Domek, Grażyna Hoser, Natalia Fedoryszak, Maciej Kawalec and Tadeusz Pacuszka
    Citation: Cellular & Molecular Biology Letters 2008 14:175
  5. Regulator of G-protein signalling (RGS)2 proteins critically regulate signalling cascades initiated by G-protein coupled receptors (GPCRs) by accelerating the deactivation of heterotrimeric G-proteins. Lysophosph...

    Authors: Jillian H. Hurst, Nisha Mendpara and Shelley B. Hooks
    Citation: Cellular & Molecular Biology Letters 2008 14:40
  6. Go, one of the most abundant heterotrimeric G proteins in the brain, is classified as a member of the Gi/Go family based on its homology to Gi proteins. Recently, we identified promyelocytic leukemia zinc fing...

    Authors: Jung Hee Won and Sung Ho Ghil
    Citation: Cellular & Molecular Biology Letters 2008 14:46
  7. Neoplastic cells frequently have an increased number of transferrin receptors. Coupling transferrin to an anti-neoplastic drug has the potential to overcome multidrug resistance (MDR). The purpose of this stud...

    Authors: Dorota Łubgan, Zofia Jóźwiak, Gerhard G. Grabenbauer and Luitpold V. R. Distel
    Citation: Cellular & Molecular Biology Letters 2008 14:113
  8. Galectin-1 is a soluble carbohydrate-binding protein with a particularly high expression in skeletal muscle. Galectin-1 has been implicated in skeletal muscle development and in adult muscle regeneration, but ...

    Authors: Anna Svensson and Sven Tågerud
    Citation: Cellular & Molecular Biology Letters 2008 14:39
  9. Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is associated with malignant transformation and is over-expressed in most human tumors. Using lipoplex-mediated transfection, we evaluated...

    Authors: Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin and Nejat Düzgüneş
    Citation: Cellular & Molecular Biology Letters 2008 14:70
  10. Ischemic diseases are characterized by the presence of pro-apoptotic stimuli, which initiate a cascade of processes that lead to cell injury and death. Several molecules and events represent detectable indicat...

    Authors: Argyrios Gerasimou, Roberta Ramella, Alessia Brero, Ombretta Boero, Imad Sheiban, Renzo Levi and Maria Pia Gallo
    Citation: Cellular & Molecular Biology Letters 2008 14:38
  11. Carnitine acetyltransferase (CRAT) is an important enzyme for energy homeostasis and fat metabolism. We characterized the predicted full length cDNA sequence of the porcine CRAT gene. Its structure is very sim...

    Authors: Annie Robic, Thomas Faraut, Laurence Liaubet and Denis Milan
    Citation: Cellular & Molecular Biology Letters 2008 14:36
  12. L1-type cell adhesion molecules (CAMs) are important mediators of neural differentiation, including axonal outgrowth and pathfinding and also of synapse formation and maintenance. In addition, their interactio...

    Authors: Michael Hortsch, Kakanahalli Nagaraj and Tanja A. Godenschwege
    Citation: Cellular & Molecular Biology Letters 2008 14:35
  13. The erythrocytes of 12-month old Sod1 −/− mice showed an increased level of reactive oxygen species (ROS), as estimated by the degree of dihydroethidine...

    Authors: Agnieszka Grzelak, Marcin Kruszewski, Ewa Macierzyńska, Łukasz Piotrowski, Łukasz Pułaski, Błażej Rychlik and Grzegorz Bartosz
    Citation: Cellular & Molecular Biology Letters 2008 14:23
  14. Endocytic processes are mediated by multiple protein-protein interacting modules and regulated by phosphorylation and dephosphorylation. The Eps15 homology domain containing protein 1 (EHD1) has been implicate...

    Authors: Boris Fichtman, Liat Ravid, Debora Rapaport and Mia Horowitz
    Citation: Cellular & Molecular Biology Letters 2008 13:27
  15. In order to investigate the effect of calnexin deletion on the induction of the main ER molecular chaperone BiP, we cultured the wild-type and calnexin-disrupted Saccharomyces cerevisiae strains under normal and ...

    Authors: Huili Zhang, Bingjie Hu, Yanyan Ji, Akio Kato and Youtao Song
    Citation: Cellular & Molecular Biology Letters 2008 13:26
  16. Aldoketoreductase 1C3 (AKR1C3) is a functional prostaglandin F synthase and a negative modulator of the availability of ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARγ)...

    Authors: Per-arne Svensson, Britt G. Gabrielsson, Margareta Jernås, Anders Gummesson and Kajsa Sjöholm
    Citation: Cellular & Molecular Biology Letters 2008 13:25
  17. Gene trapping is used to introduce genome-wide insertional mutations in embryonic stem cells. Determining the integration site is based on highthroughput PCR, which has inevitable possibilities for mistakes, t...

    Authors: Anna Gorelik, Tamar Sapir and Orly Reiner
    Citation: Cellular & Molecular Biology Letters 2008 13:28
  18. We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSF...

    Authors: Agnieszka Galanty, Marta Michalik, Łukasz Sędek and Irma Podolak
    Citation: Cellular & Molecular Biology Letters 2008 13:13
  19. We describe the identification and characterization of a GTP-binding protein with a molecular weight of 45 kD (Gbp45). Gbp45 cDNA was found to overlap with a hypothetical human protein, PTD004, the sequence of...

    Authors: Yukimi Kira and Manabu Nishikawa
    Citation: Cellular & Molecular Biology Letters 2008 13:570
  20. Resveratrol (RES), a component of red wine, possesses anti-inflammatory properties. The studies described in the present work were aimed at evaluating the potential for RES and related stilbene analogs (piceat...

    Authors: Blase Billack, Vijayalaxmi Radkar and Christelle Adiabouah
    Citation: Cellular & Molecular Biology Letters 2008 13:22
  21. Ion channels are large transmembrane proteins that are able to conduct small inorganic ions. They are characterized by high selectivity and the ability to gate, i.e. to modify their conductance in response to ...

    Authors: Krzysztof Małysiak and Zbigniew J. Grzywna
    Citation: Cellular & Molecular Biology Letters 2008 13:535
  22. We describe a new factor in the recovery from inactivation in the ball and chain model. We propose a model in which the tension from the chain may help pull the ball away from its binding site, reducing the du...

    Authors: Przemysław Borys and Zbigniew J. Grzywna
    Citation: Cellular & Molecular Biology Letters 2008 13:526
  23. In order to exert their activity, transcription factors must be transported to the nucleus. Certain transcription factors have also been found on mitochondria. Here, the localization of RelB and NFATx in the m...

    Authors: Izabela Stasik, Andrzej Rapak, Ewa Zioło and Leon Strządała
    Citation: Cellular & Molecular Biology Letters 2008 13:19
  24. The laminin-binding protein, variously called the 37/67-kDa high affinity laminin receptor or p40, mediates the attachment of normal cells to the laminin network, and also has a role as a ribosomal protein. Ov...

    Authors: Tharinee Susantad and Duncan R. Smith
    Citation: Cellular & Molecular Biology Letters 2008 13:17
  25. Mouse chondrolectin (chodl) was isolated out of the tail tip of four-day old 129/SvJ mice as a by-product of a PCR-based subtractive cDNA library screening. The gene is predominantly expressed in adult skeletal m...

    Authors: An Claessens, Christine Weyn and Joseph Merregaert
    Citation: Cellular & Molecular Biology Letters 2008 13:52
  26. Abstract: Previously, we identified a novel correlation between the upregulated expression of telomerase (hTERT) and cytochrome P450 1A1 (CYP1A1) in A549 human lung cancer cell line. The expression correlation wa...

    Authors: Kulthum Mohammed and Amal Shervington
    Citation: Cellular & Molecular Biology Letters 2008 13:50
  27. The aim of this study was to evaluate the effect of carvedilol on the enzymatic antioxidative defence and plasma antioxidative activity in patients with stable angina. The study comprised 30 patients, aged 37–...

    Authors: Jan Kowalski, Maciej Banach, Marcin Barylski, Robert Irzmanski and Lucjan Pawlicki
    Citation: Cellular & Molecular Biology Letters 2008 13:49
  28. Proteases, also referred to as peptidases, are the enzymes that catalyse the hydrolysis of peptide bonds in polipeptides. A variety of biological functions and processes depend on their activity. Regardless of...

    Authors: Benedykt Władyka and Katarzyna Pustelny
    Citation: Cellular & Molecular Biology Letters 2008 13:48
  29. The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activiti...

    Authors: Mariusz Piechota, Maciej Banach, Anna Jacoń and Jacek Rysz
    Citation: Cellular & Molecular Biology Letters 2008 13:46
  30. In this study, we investigated apoptosis induced in human trisomic and diabetic fibroblasts by daunorubicin (DNR) and its derivative, idarubicin (IDA). The cells were incubated with DNR or IDA for 2 h and then...

    Authors: Sylwia Dragojew, Agnieszka Marczak, Janusz Maszewski, Krzysztof Ilnicki and Zofia Jóźwiak
    Citation: Cellular & Molecular Biology Letters 2008 13:45
  31. Altered tissue water homeostasis may contribute to edema formation during various stresses including bacterial infection. We observed induction of aquaporin-1 (AQP1) during Staphylococcus aureus infection of cult...

    Authors: Kelly Schweitzer, Erran Li, Venkataramana Sidhaye, Virginia Leitch, Sergey Kuznetsov and Landon S. King
    Citation: Cellular & Molecular Biology Letters 2008 13:44
  32. This study focused on the function of hnRNP-R in the regulation of c-fos expression. We demonstrated that hnRNP-R accelerated the rise and decline phases of c-fos mRNAs and Fos proteins, allowing PMA to induce an...

    Authors: Jia Huang, Shu-Jing Li, Xian-Hua Chen, Yu Han and Ping Xu
    Citation: Cellular & Molecular Biology Letters 2008 13:2
  33. Although there are many reports about the efficacy of siRNAs, it is not clear whether those siRNAs with high C/G contents can be used to silence their target mRNAs efficiently. In this study, we investigated t...

    Authors: Jie-Ying Liao, James Q. Yin, Fang Chen, Tie-Gang Liu and Jia-Chang Yue
    Citation: Cellular & Molecular Biology Letters 2008 13:1
  34. Membranes made from binary mixtures of egg sphingomyelin (ESM) and cholesterol were investigated using conventional and saturation-recovery EPR observations of the 5-doxylstearic acid spin label (5-SASL). The ...

    Authors: Anna Wisniewska and Witold K. Subczynski
    Citation: Cellular & Molecular Biology Letters 2008 13:12
  35. Ionic channels form pores in biomembranes. These pores are large macromolecular structures. Due to thermal fluctuations of countless degrees-of-freedom of the biomembrane material, the actual form of the pores...

    Authors: Aleksander Wozinski and Jan Iwaniszewski
    Citation: Cellular & Molecular Biology Letters 2008 13:10
  36. p73, a member of the p53 family, exhibits activities similar to those of p53, including the ability to induce growth arrest and apoptosis. p73 influences chemotherapeutic responses in human cancer patients, in...

    Authors: Jitka Holcakova, Pavla Ceskova, Roman Hrstka, Petr Muller, Lenka Dubska, Philip J. Coates, Emil Palecek and Borivoj Vojtesek
    Citation: Cellular & Molecular Biology Letters 2008 13:11
  37. The human ZNF300 gene is a member of the KRAB/C2H2 zinc finger gene family, the members of which are known to be involved in various developmental and pathological processes. Here, we show that the ZNF300 gene en...

    Authors: Hongling Qiu, Lu Xue, Li Gao, Huanjie Shao, Di Wang, Mingxiong Guo and Wenxin Li
    Citation: Cellular & Molecular Biology Letters 2008 13:5
  38. Malignant prostate tissues have markedly reduced zinc (Zn2+) contents in comparison to non-malignant tissues. In this study, we restored a high intracellular Zn2+ level to LNCaP prostate cancer cells by culturing...

    Authors: Pooi-Fong Wong and Sazaly Abubakar
    Citation: Cellular & Molecular Biology Letters 2008 13:9
  39. This report describes an improvement made to the horizontal cell electrophoresis methodology. It involves using two liquid layers differing in density to produce an interface described as a “density cushion”. ...

    Authors: Anna Wilk, Katarzyna Urbańska, David E. Woolley and Włodzimierz Korohoda
    Citation: Cellular & Molecular Biology Letters 2008 13:7
  40. STGC3 is a novel candidate tumor suppressor gene that was found to be associated with nasopharyngeal carcinoma (NPC) via the cDNA cloning and RACE processes. The biological function of th...

    Authors: Xiu-Sheng He, Min Deng, Shuai Yang, Zhi-Qiang Xiao, Qiao Luo, Zhi-min He, Bo Hu and Zhu-Chu Chen
    Citation: Cellular & Molecular Biology Letters 2008 13:6
  41. Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid abundant in the common fruits, herbs and vegetables constituting the bulk of the human diet. This study was aimed at quantifying the effects of apigenin on t...

    Authors: Marta Czernik, Jolanta Sroka, Zbigniew Madeja and Jarosław Czyż
    Citation: Cellular & Molecular Biology Letters 2008 13:3

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