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Cellular & Molecular Biology Letters was founded in 1996 and transferred to BioMed Central in 2016. Previously, its publishers were Walter De Gruyter in 2015 (content available from De Gruyter's archive), and Springer from 2006–2014 (content available from BMC web page). Articles published between 1996 and 2005 can be found at, CMBL home page, the Volume List tab. To request free electronic versions of these articles, please contact

Thematic Series

Invited Papers

The papers in this collection were specially invited by the editors and represent work by leading researchers in their fields, as well the authors of the most cited papers from the previous issues of our journal (CMBL).

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  1. Review

    Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator

    Synonymous or silent mutations are often overlooked in genetic analyses for disease-causing mutations unless they are directly associated with potential splicing defects. More recent studies, however, indicate...

    Rafal Bartoszewski, Jaroslaw Króliczewski, Arkadiusz Piotrowski, Anna Janaszak Jasiecka, Sylwia Bartoszewska, Briana Vecchio-Pagan, Lianwu Fu, Aleksandra Sobolewska, Sadis Matalon, Garry R. Cutting, Steven M. Rowe and James F. Collawn

    Cellular & Molecular Biology Letters 2016 21:23

    Published on: 19 October 2016

  2. Research article

    Serum depletion induces changes in protein expression in the trophoblast-derived cell line HTR-8/SVneo

    How nutrition and growth factor restriction due to serum depletion affect trophoblast function remains poorly understood. We performed a proteomic differential study of the effects of serum depletion on a firs...

    Susana Novoa-Herran, Adriana Umaña-Perez, Francesc Canals and Myriam Sanchez-Gomez

    Cellular & Molecular Biology Letters 2016 21:22

    Published on: 16 October 2016

  3. Short report

    A computationally constructed ceRNA interaction network based on a comparison of the SHEE and SHEEC cell lines

    Long non-coding RNAs (lncRNAs) play critical and complicated roles in the regulation of various biological processes, including chromatin modification, transcription and post-transcriptional processing. Intere...

    Jiachun Sun, Junqiang Yan, Xiaozhi Yuan, Ruina Yang, Tanyou Dan, Xinshuai Wang, Guoqiang Kong and Shegan Gao

    Cellular & Molecular Biology Letters 2016 21:21

    Published on: 26 September 2016

  4. Short report

    The role of Exo70 in vascular smooth muscle cell migration

    As a key subunit of the exocyst complex, Exo70 has highly conserved sequence and is widely found in yeast, mammals, and plants. In yeast, Exo70 mediates the process of exocytosis and promotes anchoring and int...

    Wenqing Ma, Yu Wang, Xiaomeng Yao, Zijian Xu, Liguo An and Miao Yin

    Cellular & Molecular Biology Letters 2016 21:20

    Published on: 22 September 2016

  5. Mini Review

    BAG2 structure, function and involvement in disease

    Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and function with other BAG family members. Functioning as a co-chaperone, it interacts with the ATPase domain of the heat shock protein...

    Lixia Qin, Jifeng Guo, Qian Zheng and Hainan Zhang

    Cellular & Molecular Biology Letters 2016 21:18

    Published on: 20 September 2016

  6. Mini review

    Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs

    Understanding the cellular pathways that regulate endothelial nitric oxide (eNOS, NOS3) expression and consequently nitric oxide (NO) bioavailability during hypoxia is a necessary aspect in the development of nov...

    Leszek Kalinowski, Anna Janaszak-Jasiecka, Anna Siekierzycka, Sylwia Bartoszewska, Marcin Woźniak, Dawid Lejnowski, James F. Collawn and Rafal Bartoszewski

    Cellular & Molecular Biology Letters 2016 21:16

    Published on: 6 September 2016

  7. Mini review

    Nuclear and nucleolar activity of linker histone variant H1.0

    Histone H1.0 belongs to the class of linker histones (H1), although it is substantially distinct from other histone H1 family members. The differences can be observed in the chromosomal location and organizati...

    Andrzej Kowalski

    Cellular & Molecular Biology Letters 2016 21:15

    Published on: 24 August 2016

  8. Research article

    Changes in expression of cartilaginous genes during chondrogenesis of Wharton’s jelly mesenchymal stem cells on three-dimensional biodegradable poly(L-lactide-co-glycolide) scaffolds

    In cartilage tissue regeneration, it is important to develop biodegradable scaffolds that provide a structural and logistic template for three-dimensional cultures of chondrocytes. In this study, we evaluated ...

    Piotr Paduszyński, Ewelina Aleksander-Konert, Alicja Zajdel, Adam Wilczok, Katarzyna Jelonek, Andrzej Witek and Zofia Dzierżewicz

    Cellular & Molecular Biology Letters 2016 21:14

    Published on: 24 August 2016

  9. Research article

    Effects of NH4CL application and removal on astrocytes and endothelial cells

    Hepatic encephalopathy (HE) is a complex disorder associated with increased ammonia levels in the brain. Although astrocytes are believed to be the principal cells affected in hyperammonemia (HA), endothelial ...

    Miha Bartolić, Andrej Vovk and Dušan Šuput

    Cellular & Molecular Biology Letters 2016 21:13

    Published on: 23 August 2016

  10. Mini review

    Osteoporosis: the current status of mesenchymal stem cell-based therapy

    Osteoporosis, or bone loss, is a progressive, systemic skeletal disease that affects millions of people worldwide. Osteoporosis is generally age related, and it is underdiagnosed because it remains asymptomati...

    Jitrada Phetfong, Tanwarat Sanvoranart, Kuneerat Nartprayut, Natakarn Nimsanor, Kanokwan Seenprachawong, Virapong Prachayasittikul and Aungkura Supokawej

    Cellular & Molecular Biology Letters 2016 21:12

    Published on: 12 August 2016

  11. Research article

    In vitro chondrogenesis of Wharton’s jelly mesenchymal stem cells in hyaluronic acid-based hydrogels

    In this study, we evaluated the usefulness of two commercially available hyaluronic acid-based hydrogels, HyStem and HyStem-C, for the cultivation of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) and their ...

    Ewelina Aleksander-Konert, Piotr Paduszyński, Alicja Zajdel, Zofia Dzierżewicz and Adam Wilczok

    Cellular & Molecular Biology Letters 2016 21:11

    Published on: 12 August 2016

  12. Short communication

    A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL

    This study focused on an extract from fermented flour from the Lady Joy variety of the common bean Phaseolus vulgaris. The extract, Lady Joy lysate (Lys LJ), is enriched in antioxidant compounds during the fermen...

    Morena Gabriele, Laura Pucci, Margherita La Marca, Daniela Lucchesi, Clara Maria Della Croce, Vincenzo Longo and Valter Lubrano

    Cellular & Molecular Biology Letters 2016 21:10

    Published on: 12 August 2016

  13. Review

    Natural antisense RNAs as mRNA regulatory elements in bacteria: a review on function and applications

    Naturally occurring antisense RNAs are small, diffusible, untranslated transcripts that pair to target RNAs at specific regions of complementarity to control their biological function by regulating gene expres...

    Fatemeh Saberi, Mehdi Kamali, Ali Najafi, Alavieh Yazdanparast and Mehrdad Moosazadeh Moghaddam

    Cellular & Molecular Biology Letters 2016 21:6

    Published on: 28 July 2016

  14. Research article

    Effect of differentiation on microRNA expression in bovine skeletal muscle satellite cells by deep sequencing

    The differentiation of skeletal muscle-derived satellite cells (MDSCs) is important in controlling muscle growth, improving livestock muscle quality, and healing of muscle-related disease. MicroRNAs (miRNAs) a...

    Wei Wei Zhang, Xiao Feng Sun, Hui Li Tong, Ya Hui Wang, Shu Feng Li, Yun Qin Yan and Guang Peng Li

    Cellular & Molecular Biology Letters 2016 21:8

    Published on: 28 July 2016

  15. Mini review

    Regulation of phosphorus uptake and utilization: transitioning from current knowledge to practical strategies

    Phosphorus is a poorly bioavailable macronutrient that is essential for crop growth and yield. Overuse of phosphorus fertilizers results in low phosphorus use efficiency (PUE), has serious environmental conseq...

    Md. Mahmudul Hasan, Md. Mainul Hasan, Jaime A. Teixeira da Silva and Xuexian Li

    Cellular & Molecular Biology Letters 2016 21:7

    Published on: 28 July 2016

  16. Short communication

    Identification of a novel deletion in the MMAA gene in two Iranian siblings with vitamin B12-responsive methylmalonic acidemia

    Adenosylcobalamin (vitamin B12) is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this enzyme are a cause of methylmalonic acidemia (MMA). Methylmalonic acidemia, cblA type, is an...

    Fatemeh Keyfi, Mohammad Reza Abbaszadegan, Arndt Rolfs, Slobodanka Orolicki, Morteza Moghaddassian and Abdolreza Varasteh

    Cellular & Molecular Biology Letters 2016 21:4

    Published on: 28 July 2016

  17. Mini review

    Toll-like receptor 2 and type 2 diabetes

    Innate immunity plays a crucial role in the pathogenesis of type 2 diabetes and related complications. Since the toll-like receptors (TLRs) are central to innate immunity, it appears that they are important pa...

    Zahra Sepehri, Zohre Kiani, Ali Akbar Nasiri and Farhad Kohan

    Cellular & Molecular Biology Letters 2016 21:2

    Published on: 28 July 2016

  18. Short communication

    The crucial role of miR-126 on suppressing progression of esophageal cancer by targeting VEGF-A

    miR-126 is a key regulator of oncogenic processes. It is functionally linked to cellular proliferation, survival and migration. Vascular endothelial growth factor A (VEGF-A), which is regarded as a tumorgenesi...

    Ranran Kong, Yuefeng Ma, Jie Feng, Shaomin Li, Wei Zhang, Jiantao Jiang, Jin Zhang, Zhe Qiao, Xiaoping Yang and Bin Zhou

    Cellular & Molecular Biology Letters 2016 21:3

    Published on: 28 July 2016

  19. Short communication

    Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma

    The prognosis for patients with esophageal cancer remains poor. Therefore, the identification of novel target molecules for the treatment of esophageal cancer is necessary. Here, we investigated the clinicopat...

    Hideyuki Ishiguro, Takehiro Wakasugi, Yukio Terashita, Nobuhiro Sakamoto, Tatsuya Tanaka, Hiroyuki Sagawa, Tomotaka Okubo and Hiromitsu Takeyama

    Cellular & Molecular Biology Letters 2016 21:5

    Published on: 28 July 2016

  20. Short communication

    WNT5A–ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3

    Wnt5A, which is a member of the non-transforming Wnt protein family, is implicated in inflammatory processes. It is also highly expressed by ovarian cancer cells. ROR2, which is a member of the Ror-family of r...

    Somayeh Arabzadeh, Ghamartaj Hossein, Zahra Salehi-Dulabi and Amir Hassan Zarnani

    Cellular & Molecular Biology Letters 2016 21:9

    Published on: 28 July 2016

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