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  1. In our previous report, the rt269I type versus the rt269L type in genotype C2 infection led to poor clinical outcomes and enhanced mitochondrial stress in infected hepatocytes. Here, we sought to investigate d...

    Authors: Yu-Min Choi, Dong Hyun Kim, Junghwa Jang, Won Hyeok Choe and Bum-Joon Kim
    Citation: Cellular & Molecular Biology Letters 2023 28:26
    Content type: Research Published on:

  2. During cell apoptosis, the C-terminus of BAP31 is cleaved by caspase-8 and generates p20BAP31, which has been shown to induce an apoptotic pathway between the endoplasmic reticulum (ER) and mitochondria. Howev...

    Authors: Xiaohan Jiang, Guoxun Li, Benzhi Zhu, Jingnan Zang, Tian Lan, Rui Jiang and Bing Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:25
    Content type: Research Published on:

  3. Sepsis is an abnormal immune response after infection, wherein the lung is the most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of current therapeutic strategies and de...

    Authors: Guo-wei Tu, Yi Zhang, Jie-fei Ma, Jun-yi Hou, Guang-wei Hao, Ying Su, Jing-chao Luo, Lulu Sheng and Zhe Luo
    Citation: Cellular & Molecular Biology Letters 2023 28:24
    Content type: Research Published on:

  4. Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is critical to maintain cellular stability and ...

    Authors: Yazhi Xing, Kun Peng, Qian Yi, Dongzhen Yu, Haibo Shi, Guang Yang and Shankai Yin
    Citation: Cellular & Molecular Biology Letters 2023 28:23
    Content type: Research Published on:

  5. Cerebral arteriovenous malformations (cAVM) are a significant cause of intracranial hemorrhagic stroke and brain damage. The arteriovenous junctions in AVM nidus are known to have hemodynamic disturbances such...

    Authors: C. L. Karthika, Vani Venugopal, B. J. Sreelakshmi, S. Krithika, Jaya Mary Thomas, Mathew Abraham, C. C. Kartha, Arumugam Rajavelu and S. Sumi
    Citation: Cellular & Molecular Biology Letters 2023 28:22
    Content type: Research Letter Published on:

  6. Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark...

    Authors: Anna Janaszak-Jasiecka, Agata Płoska, Joanna M. Wierońska, Lawrence W. Dobrucki and Leszek Kalinowski
    Citation: Cellular & Molecular Biology Letters 2023 28:21
    Content type: Review Letter Published on:

  7. Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function. Our previous study has proved that miR-92a could ameliorat...

    Authors: Ming Ma, Hui Li, Saifu Yin, Tao Lin and Turun Song
    Citation: Cellular & Molecular Biology Letters 2023 28:20
    Content type: Research Letter Published on:

  8. Three-dimensional (3D) genomics is an emerging discipline that studies the three-dimensional structure of chromatin and the three-dimensional and functions of genomes. It mainly studies the three-dimensional c...

    Authors: Mengjie Chen, Xingyu Liu, Qingyou Liu, Deshun Shi and Hui Li
    Citation: Cellular & Molecular Biology Letters 2023 28:19
    Content type: Review Letter Published on:

  9. Brain microvascular endothelial cell (BMEC) injury can affect neuronal survival by modulating immune responses through the microenvironment. Exosomes are important vehicles of transport between cells. However,...

    Authors: Mengqi Zhang, Qian Wu, Mimi Tang, Zhuohui Chen and Haiyue Wu
    Citation: Cellular & Molecular Biology Letters 2023 28:18
    Content type: Research Letter Published on:

  10. Bidirectional communication between presynaptic and postsynaptic components contribute to the homeostasis of the synapse. In the neuromuscular synapse, the arrival of the nerve impulse at the presynaptic termi...

    Authors: Aleksandra Polishchuk, Víctor Cilleros-Mañé, Laia Just-Borràs, Marta Balanyà-Segura, Genís Vandellòs Pont, Carolina Silvera Simón, Marta Tomàs, Neus Garcia, Josep Tomàs and Maria A. Lanuza
    Citation: Cellular & Molecular Biology Letters 2023 28:17
    Content type: Research Published on:

  11. Testicular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal development of the gubernaculum is one of the important factors of testicular h...

    Authors: Shouxing Duan, Xuewu Jiang, Jianhong Li, Maxian Fu, Zhuo Li, Yiyi Cheng, Yangmu Zhuang, Ming Yang, Wenfeng Xiao, Hongyan Ping, Yao Xie, Xiaojun Xie and Xuan Zhang
    Citation: Cellular & Molecular Biology Letters 2023 28:16
    Content type: Research Letter Published on:

  12. Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) are involved in various muscle pathological states. The IRE1α arm of UPR can affect immunological properties of myofiber through restr...

    Authors: Jiangwei Xiao, Jingwen Huang, Xiaoting Jian, Han Wang, Haiqiang Lan, Zhaohong Liao, Ruicai Gu, Jijie Hu and Hua Liao
    Citation: Cellular & Molecular Biology Letters 2023 28:15
    Content type: Research Published on:

  13. The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein–Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregul...

    Authors: Maša Mavri, Sanja Glišić, Milan Senćanski, Milka Vrecl, Mette M. Rosenkilde, Katja Spiess and Valentina Kubale
    Citation: Cellular & Molecular Biology Letters 2023 28:14
    Content type: Research Letter Published on:

  14. Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be ass...

    Authors: Wenjian Yao, Xiangbo Jia, Li Zhu, Lei Xu, Quan Zhang, Tian Xia and Li Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:13
    Content type: Research Published on:

  15. Kidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelial cell injury and death, leading to acute kidney injury and the transformation of acute...

    Authors: Yihang Yu, Meiling Chen, Qitong Guo, Lianju Shen, Xing Liu, Jianbo Pan, Yuanyuan Zhang, Tao Xu, Deying Zhang and Guanghui Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:12
    Content type: Research Published on:

  16. Glyphosate (GLY), as the active ingredient of the most widely used herbicide worldwide, is commonly detected in the environment and living organisms, including humans. Its toxicity and carcinogenicity in mamma...

    Authors: Jiangpeng Wu, Xiuping Sun, Chunyi Wu, Xiaoping Hong, Lulin Xie, Zixu Shi, Liang Zhao, Qingfeng Du, Wei Xiao, Jichao Sun and Jigang Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:11
    Content type: Research Letter Published on:

  17. TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 ...

    Authors: Asfia Soomro, Mohammad Khajehei, Renzhong Li, Kian O’Neil, Dan Zhang, Bo Gao, Melissa MacDonald, Masao Kakoki and Joan C. Krepinsky
    Citation: Cellular & Molecular Biology Letters 2023 28:10
    Content type: Research Published on:

  18. Bone marrow-derived mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs) have shown potent anti-inflammatory function in various pathological conditions, such as osteoarthritis and neurodegenera...

    Authors: Xueke Li, Yi Zhong, Wuqi Zhou, Yishu Song, Wenqu Li, Qiaofeng Jin, Tang Gao, Li Zhang and Mingxing Xie
    Citation: Cellular & Molecular Biology Letters 2023 28:9
    Content type: Research Letter Published on:

  19. Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hypothesis contrasts insufficient experimental evidence. The q...

    Authors: Caroline Diener, Martin Hart, Claudia Fecher-Trost, Jessica Knittel, Stefanie Rheinheimer, Markus R. Meyer, Jens Mayer, Veit Flockerzi, Andreas Keller and Eckart Meese
    Citation: Cellular & Molecular Biology Letters 2023 28:8
    Content type: Research Letter Published on:

  20. Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemical signals and thereby trigger osteogenic programs necessary for alveolar bone remodeli...

    Authors: Jixiao Wang, Huiqi Yang, Xiaobei Ma, Jiani Liu, Lan Li, Lei Chen and Fulan Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:7
    Content type: Research Published on:

  21. Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumors in adults. Despite significant breakthroughs in standard treatment, only about 5% of ...

    Authors: Hamed Hosseinalizadeh, Omid Mohamadzadeh, Mohammad Saeed Kahrizi, Zahra Razaghi Bahabadi, Daniel J. Klionsky and Hamed Mirzei
    Citation: Cellular & Molecular Biology Letters 2023 28:6
    Content type: Review Letter Published on:

  22. Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects the recovery of motor function. Bone-marrow-derived macrophages (BMDMs) were recruited t...

    Authors: Cheng Ju, Yangguang Ma, Xiaoshuang Zuo, Xuankang Wang, Zhiwen Song, Zhihao Zhang, Zhijie Zhu, Xin Li, Zhuowen Liang, Tan Ding, Xueyu Hu and Zhe Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:5
    Content type: Research Published on:

  23. Ischemia–reperfusion injury (IRI) is an inevitable process in renal transplantation that significantly increases the risk of delayed graft function, acute rejection, and even graft loss. Formyl peptide recepto...

    Authors: Yirui Cao, Juntao Chen, Feng Liu, Guisheng Qi, Yufeng Zhao, Shihao Xu, Jiyan Wang, Tongyu Zhu, Yi Zhang and Yichen Jia
    Citation: Cellular & Molecular Biology Letters 2023 28:4
    Content type: Research Published on:

  24. Authors: Junqiang Li, Yang Song, Chao Zhang, Ronglin Wang, Lei Hua, Yongdong Guo, Dongxue Gan, Liaoliao Zhu, Shanshan Li, Peixiang Ma, Cheng Yang, Hong Li, Jing Yang, Jingjie Shi, Xiaonan Liu and Haichuan Su
    Citation: Cellular & Molecular Biology Letters 2023 28:3
    Content type: Correction Published on:

    The original article was published in Cellular & Molecular Biology Letters 2022 27:24

  25. Hematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dysfunction. While much emphasis is on the reconstitution of hematopoietic stem cells in t...

    Authors: Seyram Yao Adzraku, Guozhang Wang, Can Cao, Yurong Bao, Yizhou Wang, Alhaji Osman Smith, Yuwei Du, Haiyang Wang, Yue Li, Kailin Xu, Jianlin Qiao, Wen Ju and Lingyu Zeng
    Citation: Cellular & Molecular Biology Letters 2023 28:2
    Content type: Research Letter Published on:

  26. Spatial chromatin structure is intricately linked with somatic aberrations, and somatic mutations of various cancer-related genes, termed co-mutations (CoMuts), occur in certain patterns during cancer initiati...

    Authors: Linlin Zhang, Miaomiao Xu, Wanchun Zhang, Chuanying Zhu, Zhilei Cui, Hongliang Fu, Yufei Ma, Shuo Huang, Jian Cui, Sheng Liang, Lei Huang and Hui Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:1
    Content type: Research Published on:

  28. Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway. Here we performed a yeast two-hybrid screen using t...

    Authors: Yan Jia, Jianing Zhao, Tao Yu, Xue Zhang, Xiaozhen Qi, Tongxin Hao, Zeyuan Jin and Xiaoqing Zhao
    Citation: Cellular & Molecular Biology Letters 2022 27:111
    Content type: Research Published on:

  29. Metabolic disorder is considered a well-established risk factor for endometrial carcinoma (EC). However, the mechanism remains unclear. Insulin resistance and excessive flux of free fatty acids serve as fundam...

    Authors: Jingyi Zhou, Yanying Lin, Xiao Yang, Boqiang Shen, Juan Hao, Jiaqi Wang and Jianliu Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:110
    Content type: Research Letter Published on:

  30. The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angio...

    Authors: Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn and Rafal Bartoszewski
    Citation: Cellular & Molecular Biology Letters 2022 27:109
    Content type: Research Published on:

  31. Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognizes double-stranded DNA. AIM2 exhibits limited expression under physiological conditions ...

    Authors: Jianan Zhao, Shicheng Guo, Steven J. Schrodi and Dongyi He
    Citation: Cellular & Molecular Biology Letters 2022 27:108
    Content type: Review Letter Published on:

  32. Oral squamous cell carcinoma (OSCC) is a common head and neck cancer, and the incidence of OSCC is increasing. As the mortality of OSCC keeps increasing, it is crucial to clarify its pathogenesis and develop n...

    Authors: Xinyu Zhang, Yong Han, Shuli Liu, Bing Guo, Shengming Xu, Yue He and Liu Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:107
    Content type: Research Published on:

  33. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. CircFUT8 has been shown to be upregulated in cancers, but its function in HCC remains unclear. Tumor-associated macrophages (TAMs) are on...

    Authors: Liyan Wang, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng, Lei Ma and Bin Li
    Citation: Cellular & Molecular Biology Letters 2022 27:106
    Content type: Research Published on:

  34. Pyrimidine metabolism is critical for tumour progression. Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits ...

    Authors: Dehai Wu, Congyi Zhang, Guanqun Liao, Kaiming Leng, Bowen Dong, Yang Yu, Huilin Tai, Lining Huang, Feng Luo, Bin Zhang, Tiexiang Zhan, Qiuhui Hu and Sheng Tai
    Citation: Cellular & Molecular Biology Letters 2022 27:105
    Content type: Research Published on:

  35. Pyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemia in brothers of Polish origin that are associated with a very rare mutation. Heterozygous de...

    Authors: Dżamila M. Bogusławska, Michał Skulski, Rafał Bartoszewski, Beata Machnicka, Elżbieta Heger, Kazimierz Kuliczkowski and Aleksander F. Sikorski
    Citation: Cellular & Molecular Biology Letters 2022 27:104
    Content type: Research Published on:

  36. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the ro...

    Authors: Tahseen S. Sayed, Zaid H. Maayah, Heba A. Zeidan, Abdelali Agouni and Hesham M. Korashy
    Citation: Cellular & Molecular Biology Letters 2022 27:103
    Content type: Review Published on:

  37. The innate immune system is the body’s first line of defense against pathogens and involves antibody and complement system-mediated antigen removal. Immune-response-related complement molecules have been ident...

    Authors: Jiali Lu, Jinsong Duan, Yinglun Han, Meng Gou, Jun Li, Qingwei Li and Yue Pang
    Citation: Cellular & Molecular Biology Letters 2022 27:102
    Content type: Research Letter Published on:

  38. RNA N6-methyladenosine (m6A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulates spermatogenesis and androgen synthesis in an m6A-dependent manner. However, it is uncle...

    Authors: Zhonglin Cai, Yao Zhang, Lin Yang, Chunhui Ma, Yi Fei, Jing Ding, Wei Song, Wei-Min Tong, Yamei Niu and Hongjun Li
    Citation: Cellular & Molecular Biology Letters 2022 27:101
    Content type: Research Letter Published on:

  39. Metformin is an inhibitor of oxidative phosphorylation that displays an array of anticancer activities. The interference of metformin with the activity of multi-drug resistance systems in cancer cells has been...

    Authors: Jessica Catapano, Marcin Luty, Tomasz Wróbel, Maciej Pudełek, Katarzyna Piwowarczyk, Sylwia Kędracka-Krok, Maciej Siedlar, Zbigniew Madeja and Jarosław Czyż
    Citation: Cellular & Molecular Biology Letters 2022 27:100
    Content type: Research Published on:

  40. tRNA-derived fragments (tRFs) are newly discovered noncoding RNAs and regulate tumor progression via diverse molecular mechanisms. However, the expression and biofunction of tRFs in gallbladder cancer (GBC) ha...

    Authors: Lu Zou, Yang Yang, Biyu Zhou, Weijian Li, Ke Liu, Guoqiang Li, Huijie Miao, Xiaoling Song, Jiahua Yang, Yajun Geng, Maolan Li, Runfa Bao and Yingbin Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:99
    Content type: Research Published on:

  41. Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be invol...

    Authors: Gaiping Wang, Anqi Chen, Yu Wu, Danlin Wang, Cuifang Chang and Guoying Yu
    Citation: Cellular & Molecular Biology Letters 2022 27:98
    Content type: Review Letter Published on:

  42. Endothelial cells (ECs) play an important role in angiogenesis and vascular reconstruction in the pathophysiology of ischemic stroke. Previous investigations have provided a profound cerebral vascular atlas un...

    Authors: Zhuohui Chen, Xiang Wang, Haiyue Wu, Yishu Fan, Zhouyi Yan, Chenxiao Lu, Hongfei Ouyang, Shiyu Zhang and Mengqi Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:97
    Content type: Research Published on:

  44. Cardiomyocyte injury is a common complication during cardiac surgery with cardiopulmonary bypass (CPB). Studies have shown that circulating small extracellular vesicles (sEVs) are involved in the pathological ...

    Authors: Ting Wu, Guoning Shi, Zhenhua Ji, Shu Wang, Lizhu Geng and Zhigang Guo
    Citation: Cellular & Molecular Biology Letters 2022 27:95
    Content type: Research Letter Published on:

  46. EVA1A (Eva-1 homolog A), a novel protein involved in autophagy and apoptosis, functions as a tumor suppressor in some human primary cancers, including hepatocellular carcinoma (HCC). While it is consistently d...

    Authors: Qian Xu, Zhaozhong Liao, Zunshuang Gong, Xiaokun Liu, Yuling Yang, Zhe Wang, Weiyan Yang, Lin Hou, Jiejie Yang, Junying Song, Wenjing Liu, Bin Wang, Junnan Hua, Mingyi Pu and Ning Li
    Citation: Cellular & Molecular Biology Letters 2022 27:93
    Content type: Research Published on:

  47. Hepatocellular carcinoma (HCC) is among the most common and malignant cancers with no effective therapeutic approaches. Echinacoside (ECH), a phenylethanoid glycoside isolated from Chinese herbal medicine, Cistan...

    Authors: Menghan Wang, Xing Ma, Guoyu Wang, Yanan Song, Miao Zhang, Zhongchao Mai, Borong Zhou, Ying Ye and Wei Xia
    Citation: Cellular & Molecular Biology Letters 2022 27:92
    Content type: Research Published on:

  48. Long non-coding RNAs (lncRNAs) are critical regulators in lung adenocarcinoma (LUAD). M2-type tumor-associated macrophages (TAMs) also play oncogenic roles in LUAD. However, the involvement of lncRNAs in TAM a...

    Authors: Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang and Chang-li Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:91
    Content type: Research Published on:

  49. E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic co...

    Authors: Zejun Fang, Min Lin, Shenghui Chen, Hong Liu, Minjing Zhu, Yanyan Hu, Shanshan Han, Yizhang Wang, Long Sun, Fengjiao Zhu, Chengfu Xu and Chaoju Gong
    Citation: Cellular & Molecular Biology Letters 2022 27:90
    Content type: Research Published on:

  50. Numerous studies have revealed that long noncoding RNAs (lncRNAs) are closely related to the development of many diseases and carcinogenesis. However, their specific biological function and molecular mechanism...

    Authors: Lihua Ren, Xin Fang, Sachin Mulmi Shrestha, Qinghua Ji, Hui Ye, Yan Liang, Yang Liu, Yadong Feng, Jingwu Dong and Ruihua Shi
    Citation: Cellular & Molecular Biology Letters 2022 27:89
    Content type: Research Published on:

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