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  1. Content type: Research

    The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, w...

    Authors: Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang and Heng Wu

    Citation: Cellular & Molecular Biology Letters 2018 23:14

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  2. Content type: Research

    Arsenic trioxide (As2O3) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2O3 has an antitumo...

    Authors: Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai and Kongbin Yang

    Citation: Cellular & Molecular Biology Letters 2018 23:13

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  3. Content type: Review

    Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is invo...

    Authors: Michaela Galoczova, Philip Coates and Borivoj Vojtesek

    Citation: Cellular & Molecular Biology Letters 2018 23:12

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  4. Content type: Short report

    Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate i...

    Authors: Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh and Majd Aljamali

    Citation: Cellular & Molecular Biology Letters 2018 23:11

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  5. Content type: Research

    The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against num...

    Authors: Laura Susan Boyd, Devrim Gozuacik and Anna Margaretha Joubert

    Citation: Cellular & Molecular Biology Letters 2018 23:10

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  6. Content type: Short report

    Previous studies indicated that cadmium (Cd) increases PI3-kinase/Akt phosphorylation, resulting in an alteration in GSK-3β activity. However, the mechanism of Cd-induced endoplasmic reticulum (ER) stress in n...

    Authors: Seungwoo Kim, Hyosoon Cheon, Sam-Moon Kim and Young-Youl Kim

    Citation: Cellular & Molecular Biology Letters 2018 23:9

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  7. Content type: Research

    Platelet-derived growth factor-C (PDGF-C) has been shown to be involved in several biological processes, such as embryonic development, wound healing and angiogenesis, as well as in diseases including tumor fo...

    Authors: Tomoaki Kinjo, Chuanhai Sun, Tomomi Ikeda, Takako Ikegami, Yuhki Tada, Tadayuki Akagi, Takashi Yokota and Hiroshi Koide

    Citation: Cellular & Molecular Biology Letters 2018 23:8

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  8. Content type: Research

    Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, i...

    Authors: Hao Yang, Di Wu, Hua Li, Nan Chen and Yongjun Shang

    Citation: Cellular & Molecular Biology Letters 2018 23:7

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  9. Content type: Research

    Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene...

    Authors: Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li and Xiaohui Zhang

    Citation: Cellular & Molecular Biology Letters 2018 23:6

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  10. Content type: Research

    Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteo...

    Authors: Nazli F. Eskici, Sevim Erdem-Ozdamar and Didem Dayangac-Erden

    Citation: Cellular & Molecular Biology Letters 2018 23:5

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  11. Content type: Research

    Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. However, the effects of CGRP ...

    Authors: Shaohua Wang, Hongxing Dang, Feng Xu, Jian Deng and Xuemei Zheng

    Citation: Cellular & Molecular Biology Letters 2018 23:4

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  12. Content type: Short report

    Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to...

    Authors: Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Shoukath M. Ali, Moghis U. Ahmad and Imran Ahmad

    Citation: Cellular & Molecular Biology Letters 2018 23:3

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  13. Content type: Research

    Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects....

    Authors: Ying Chen, Lei Zhang, Wen-xin Liu and Ke Wang

    Citation: Cellular & Molecular Biology Letters 2018 23:2

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  14. Content type: Short report

    Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apop...

    Authors: Yanan Li, Yu Yan, Fang Liu, Ming Wang, Fumin Feng and Yonghong Xiao

    Citation: Cellular & Molecular Biology Letters 2018 23:1

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  15. Content type: Short report

    The transcription factor TWIST1 plays an important role in the epithelial–mesenchymal transition (EMT) process and in the migration, invasion and metastasis of cancer cells. OCT4, which is a homeobox transcrip...

    Authors: Mohammad Hossein Izadpanah, Mohammad Reza Abbaszadegan, Yasaman Fahim and Mohammad Mahdi Forghanifard

    Citation: Cellular & Molecular Biology Letters 2017 22:33

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  16. Content type: Short report

    Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy. Semaphorin 3F (SEMA3F) is highly conserved but present at a lower level in various cancers than in healthy tissues. While it h...

    Authors: Yi Liu, Ronghua Li, Kai Yin, Gang Ren and Yongdong Zhang

    Citation: Cellular & Molecular Biology Letters 2017 22:32

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  17. Content type: Short report

    The natural dihydroflavonol (+) taxifolin was investigated for its protective effect on Fenton reagent-treated bone marrow-derived mesenchymal stem cells (bmMSCs). Various antioxidant assays were used to deter...

    Authors: Xican Li, Hong Xie, Qian Jiang, Gang Wei, Lishan Lin, Changying Li, Xingmei Ou, Lichan Yang, Yulu Xie, Zhen Fu, Yamei Liu and Dongfeng Chen

    Citation: Cellular & Molecular Biology Letters 2017 22:31

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  18. Content type: Research

    Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are invo...

    Authors: Jian Ge, Qianxue Chen, Baohui Liu, Long Wang, Shenqi Zhang and Baowei Ji

    Citation: Cellular & Molecular Biology Letters 2017 22:30

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  19. Content type: Research

    Several recent studies have demonstrated the great potential of bone marrow cells in regenerative medicine, not only for their ability to differentiate to match a damaged cell type, but also because they synth...

    Authors: Yolanda Menéndez-Menéndez, Jesús Otero-Hernández, Jose Antonio Vega, Marcos Pérez-Basterrechea, Silvia Pérez-López, María Álvarez-Viejo and Amaia Ferrero-Gutiérrez

    Citation: Cellular & Molecular Biology Letters 2017 22:29

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  20. Content type: Review

    The development and integration of bio- and chemocatalytic processes to convert renewable or biomass feedstocks into polymers is a vibrant field of research with enormous potential for environmental protection...

    Authors: Aleksandra Marszałek-Harych, Dawid Jędrzkiewicz and Jolanta Ejfler

    Citation: Cellular & Molecular Biology Letters 2017 22:28

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  21. Content type: Short report

    Prolyl-hydroxyproline (Pro-Hyp) is one of the major constituents of collagen-derived dipeptides. We previously reported that Pro-Hyp promotes the differentiation of osteoblasts by increasing Runx2, osterix and...

    Authors: Yoshifumi Kimira, Haruka Odaira, Kaho Nomura, Yuri Taniuchi, Naoki Inoue, Sachie Nakatani, Jun Shimizu, Masahiro Wada and Hiroshi Mano

    Citation: Cellular & Molecular Biology Letters 2017 22:27

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  22. Content type: Short report

    Many studies have investigated the characteristics and biological activities of type III interferon (IFN), finding that it has similar features to type I IFN but also unique actions because it is recognized by...

    Authors: Wu-mei Yuan, Wan-ju Zhang, Fen-lian Ma, Jin-song Li, Qian Zhang and Li-shu Zheng

    Citation: Cellular & Molecular Biology Letters 2017 22:26

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  23. Content type: Short report

    The rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the ...

    Authors: Arati Suvatha, Sibin Madathan Kandi, Dhananjaya Ishwara Bhat, Narasinga Rao, Vikas Vazhayil and Chetan Ghati Kasturirangan

    Citation: Cellular & Molecular Biology Letters 2017 22:25

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  24. Content type: Research

    Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The study aimed to explore the potential role of heat shock protein 27 (HSP27) in the pathogenesis of TAD using an in vitro model of ...

    Authors: Sili Zou, Mingfang Liao, Junlin Yang, Tong Huang, Mark Green, Jianjin Wu and Lefeng Qu

    Citation: Cellular & Molecular Biology Letters 2017 22:24

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  25. Content type: Research article

    Hypoxic conditions induce the expression of hypoxia-inducible factors (HIFs) that allow cells to adapt to the changing conditions and alter the expression of a number of genes including the cystic fibrosis tra...

    Authors: Sylwia Bartoszewska, Wojciech Kamysz, Bogdan Jakiela, Marek Sanak, Jarosław Króliczewski, Zsuzsa Bebok, Rafal Bartoszewski and James F. Collawn

    Citation: Cellular & Molecular Biology Letters 2017 22:23

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  26. Content type: Research

    TGF-β1 plays an important role in the epithelial–mesenchymal transition (EMT) of epithelial cancers, including non-small cell lung cancer (NSCLC). While the full underlying mechanism remains unclear, miR-9 is ...

    Authors: Hui Wang, Qian Wu, Ying Zhang, Hua-Nan Zhang, Yong-Bin Wang and Wei Wang

    Citation: Cellular & Molecular Biology Letters 2017 22:22

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  27. Content type: Short report

    Our previous study found that single-pass membrane protein with coiled-coil domains 1 (C3orf43; XM_006248472.3) was significantly upregulated in the proliferative phase during liver regeneration. This indicate...

    Authors: Chunyan Zhang, Cuifang Chang, Deming Li, Fuchun Zhang and Cunshuan Xu

    Citation: Cellular & Molecular Biology Letters 2017 22:21

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  28. Content type: Mini review

    Clinicians use clinical and pathological parameters, such as tumour size, grade and nodal status, to make decisions on adjuvant treatments for breast cancer. However, therapeutic decisions based on these featu...

    Authors: Umar Wazir, Kinan Mokbel, Amtul Carmichael and Kefah Mokbel

    Citation: Cellular & Molecular Biology Letters 2017 22:20

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  29. Content type: Research

    One of the microorganisms from dental plaque associated with severe inflammatory responses in infectious endocarditis is Porphyromonas gingivalis. It is a Gram-negative bacteria harvested from chronic periodontit...

    Authors: Gloria Gutiérrez-Venegas, Alfredo Torras-Ceballos, Juan Arturo Gómez-Mora and Berenice Fernández-Rojas

    Citation: Cellular & Molecular Biology Letters 2017 22:19

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  30. Content type: Review

    In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly of DNA-protein complex, ch...

    Authors: Sergey V. Razin and Sergey V. Ulianov

    Citation: Cellular & Molecular Biology Letters 2017 22:18

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  31. Content type: Short report

    Retinoblastoma (RB), a childhood cancer, is caused by biallelic mutation of the RB1 gene, but its development is not clearly understood. Furthermore, the presence of a cancer stem cell subpopulation in RB might i...

    Authors: Suganya Sivagurunathan, Jayamuruga Pandian Arunachalam and Subbulakshmi Chidambaram

    Citation: Cellular & Molecular Biology Letters 2017 22:17

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  32. Content type: Short report

    Nur-77, a member of the NR4A sub-family of nuclear orphan receptors, is downregulated in the placentae of pre-eclamptic women. Here, we investigate the relevance of Nor-1, Nurr-1 and Nur-77 in trophoblastic ce...

    Authors: Sudha Saryu Malhotra and Satish Kumar Gupta

    Citation: Cellular & Molecular Biology Letters 2017 22:15

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  33. Content type: Research

    Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs ...

    Authors: Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong and Zhaochen Shan

    Citation: Cellular & Molecular Biology Letters 2017 22:14

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  34. Content type: Research

    FFA1 is abundantly expressed in the liver, skeletal muscle, monocytes and nervous system, but is particularly abundant in pancreatic β cells. It is widely believed that FFA1 exerts its regulatory roles in a va...

    Authors: Jing Qian, Yuyang Gu, Chun Wu, Feng Yu, Yuqi Chen, Jingmei Zhu, Xingyi Yao, Chen Bei and Qingqing Zhu

    Citation: Cellular & Molecular Biology Letters 2017 22:13

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  35. Content type: Research

    MicroRNAs (miRNAs) play important roles in the growth and metastasis of colon cancer. It is known that one set of miRNAs are dysregulated in colon cancer cells, but the mechanism of their role in cancer develo...

    Authors: Mingxi Zeng, Linlin Zhu, Liangping Li and Changming Kang

    Citation: Cellular & Molecular Biology Letters 2017 22:12

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  36. Content type: Review

    Human milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to proteins, lipids, carbohydrates and other biologically active components, breast milk contain...

    Authors: Malgorzata Witkowska-Zimny and Ewa Kaminska-El-Hassan

    Citation: Cellular & Molecular Biology Letters 2017 22:11

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  37. Content type: Short report

    H19 is a well-characterized Long noncoding RNA (lncRNA) that has been proven to promote myoblast differentiation in humans and mice. However, its mechanism of action is still not fully interpreted.

    Authors: Xiaochun Xu, Shengyue Ji, Weili Li, Bao Yi, Hengxin Li, Hongfu Zhang and Wenping Ma

    Citation: Cellular & Molecular Biology Letters 2017 22:10

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  38. Content type: Short report

    The gene that encodes tumor protein p53, Tp53, is mutated or silenced in most human cancers and is recognized as one of the most important cancer drivers. Homozygotic Tp53 knockout mice, which develop lethal canc...

    Authors: Damian Strzemecki, Magdalena Guzowska and Paweł Grieb

    Citation: Cellular & Molecular Biology Letters 2017 22:9

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  39. Content type: Review

    Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggr...

    Authors: Zakir Khan, Abdul Arif Khan, Hariom Yadav, Godavarthi B. K. S. Prasad and Prakash Singh Bisen

    Citation: Cellular & Molecular Biology Letters 2017 22:8

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  40. Content type: Short Report

    Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists. It is caused by inactivating mutat...

    Authors: Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino and Faustino Bisaccia

    Citation: Cellular & Molecular Biology Letters 2017 22:7

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  41. Content type: Short report

    Although the 3T3-L1 preadipocyte cell line represents an informative model for in vitro adipogenesis research, primary cultured cells are often needed to understand particular human or animal metabolic phenotypes...

    Authors: Yong Pu and Almudena Veiga-Lopez

    Citation: Cellular & Molecular Biology Letters 2017 22:6

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  42. Content type: Research

    Human Tenon’s fibroblasts (HTFs) play a crucial role in wound healing. They cause postoperative scarring of the filtering bleb and are thus responsible for trabeculectomy failure. This study aimed to find an e...

    Authors: Agata Przekora, Tomasz Zarnowski and Grazyna Ginalska

    Citation: Cellular & Molecular Biology Letters 2017 22:5

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  43. Content type: Mini review

    Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), is a surface type I transmembrane core proteoglycan that is crucially involved in cell survival, migration and angiogene...

    Authors: Emmanuel Ampofo, Beate M. Schmitt, Michael D. Menger and Matthias W. Laschke

    Citation: Cellular & Molecular Biology Letters 2017 22:4

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  44. Content type: Research

    Atherosclerosis is a chronically inflammatory disease and one of the leading causes of deaths worldwide. Endothelial cell apoptosis plays a crucial role in its development. Several microRNAs (miRNAs) are repor...

    Authors: Ying Li, Chunyan Yang, Lili Zhang and Ping Yang

    Citation: Cellular & Molecular Biology Letters 2017 22:3

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  45. Content type: Short report

    PU box-binding protein (PU.1) is a master gene of hematopoietic lineage and an important specific transcription factor in osteoclast lineage. There is proof of its expression in adipose tissue, and it is known...

    Authors: ChongMei Ruan, Xiu Li, JunJie Hu, Yong Zhang and XingXu Zhao

    Citation: Cellular & Molecular Biology Letters 2017 22:2

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  46. Content type: Research

    The harmful side effects of electroporation to cells due to local changes in pH, the appearance of toxic electrode products, temperature increase, and the heterogeneity of the electric field acting on cells in...

    Authors: Maciej Grys, Zbigniew Madeja and Włodzimierz Korohoda

    Citation: Cellular & Molecular Biology Letters 2017 22:1

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  47. Content type: Mini review

    The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body...

    Authors: Wei Jing Liu, Lin Ye, Wei Fang Huang, Lin Jie Guo, Zi Gan Xu, Hong Luan Wu, Chen Yang and Hua Feng Liu

    Citation: Cellular & Molecular Biology Letters 2016 21:29

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  48. Content type: Short report

    Immunoglobulin G (IgG) has been implicated in the progression of various cancers. This study explored the role of IgG in the proliferation, apoptosis, cell cycle and in vitro invasive properties of LNCaP prost...

    Authors: Yawen Xu, Binshen Chen, Shaobo Zheng, Yong Wen, Abai Xu, Kai Xu, Bingkun Li and Chunxiao Liu

    Citation: Cellular & Molecular Biology Letters 2016 21:27

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