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  1. Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene...

    Authors: Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li and Xiaohui Zhang

    Citation: Cellular & Molecular Biology Letters 2018 23:6

    Content type: Research

    Published on:

  2. Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteo...

    Authors: Nazli F. Eskici, Sevim Erdem-Ozdamar and Didem Dayangac-Erden

    Citation: Cellular & Molecular Biology Letters 2018 23:5

    Content type: Research

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  3. Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. However, the effects of CGRP ...

    Authors: Shaohua Wang, Hongxing Dang, Feng Xu, Jian Deng and Xuemei Zheng

    Citation: Cellular & Molecular Biology Letters 2018 23:4

    Content type: Research

    Published on:

  4. Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to...

    Authors: Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Shoukath M. Ali, Moghis U. Ahmad and Imran Ahmad

    Citation: Cellular & Molecular Biology Letters 2018 23:3

    Content type: Short report

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  5. Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects....

    Authors: Ying Chen, Lei Zhang, Wen-xin Liu and Ke Wang

    Citation: Cellular & Molecular Biology Letters 2018 23:2

    Content type: Research

    Published on:

  6. Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apop...

    Authors: Yanan Li, Yu Yan, Fang Liu, Ming Wang, Fumin Feng and Yonghong Xiao

    Citation: Cellular & Molecular Biology Letters 2018 23:1

    Content type: Short report

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  7. The transcription factor TWIST1 plays an important role in the epithelial–mesenchymal transition (EMT) process and in the migration, invasion and metastasis of cancer cells. OCT4, which is a homeobox transcrip...

    Authors: Mohammad Hossein Izadpanah, Mohammad Reza Abbaszadegan, Yasaman Fahim and Mohammad Mahdi Forghanifard

    Citation: Cellular & Molecular Biology Letters 2017 22:33

    Content type: Short report

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  8. Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy. Semaphorin 3F (SEMA3F) is highly conserved but present at a lower level in various cancers than in healthy tissues. While it h...

    Authors: Yi Liu, Ronghua Li, Kai Yin, Gang Ren and Yongdong Zhang

    Citation: Cellular & Molecular Biology Letters 2017 22:32

    Content type: Short report

    Published on:

  9. The natural dihydroflavonol (+) taxifolin was investigated for its protective effect on Fenton reagent-treated bone marrow-derived mesenchymal stem cells (bmMSCs). Various antioxidant assays were used to deter...

    Authors: Xican Li, Hong Xie, Qian Jiang, Gang Wei, Lishan Lin, Changying Li, Xingmei Ou, Lichan Yang, Yulu Xie, Zhen Fu, Yamei Liu and Dongfeng Chen

    Citation: Cellular & Molecular Biology Letters 2017 22:31

    Content type: Short report

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  10. Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are invo...

    Authors: Jian Ge, Qianxue Chen, Baohui Liu, Long Wang, Shenqi Zhang and Baowei Ji

    Citation: Cellular & Molecular Biology Letters 2017 22:30

    Content type: Research

    Published on:

  11. Several recent studies have demonstrated the great potential of bone marrow cells in regenerative medicine, not only for their ability to differentiate to match a damaged cell type, but also because they synth...

    Authors: Yolanda Menéndez-Menéndez, Jesús Otero-Hernández, Jose Antonio Vega, Marcos Pérez-Basterrechea, Silvia Pérez-López, María Álvarez-Viejo and Amaia Ferrero-Gutiérrez

    Citation: Cellular & Molecular Biology Letters 2017 22:29

    Content type: Research

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  12. The development and integration of bio- and chemocatalytic processes to convert renewable or biomass feedstocks into polymers is a vibrant field of research with enormous potential for environmental protection...

    Authors: Aleksandra Marszałek-Harych, Dawid Jędrzkiewicz and Jolanta Ejfler

    Citation: Cellular & Molecular Biology Letters 2017 22:28

    Content type: Review

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  13. Prolyl-hydroxyproline (Pro-Hyp) is one of the major constituents of collagen-derived dipeptides. We previously reported that Pro-Hyp promotes the differentiation of osteoblasts by increasing Runx2, osterix and...

    Authors: Yoshifumi Kimira, Haruka Odaira, Kaho Nomura, Yuri Taniuchi, Naoki Inoue, Sachie Nakatani, Jun Shimizu, Masahiro Wada and Hiroshi Mano

    Citation: Cellular & Molecular Biology Letters 2017 22:27

    Content type: Short report

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  14. Many studies have investigated the characteristics and biological activities of type III interferon (IFN), finding that it has similar features to type I IFN but also unique actions because it is recognized by...

    Authors: Wu-mei Yuan, Wan-ju Zhang, Fen-lian Ma, Jin-song Li, Qian Zhang and Li-shu Zheng

    Citation: Cellular & Molecular Biology Letters 2017 22:26

    Content type: Short report

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  15. The rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the ...

    Authors: Arati Suvatha, Sibin Madathan Kandi, Dhananjaya Ishwara Bhat, Narasinga Rao, Vikas Vazhayil and Chetan Ghati Kasturirangan

    Citation: Cellular & Molecular Biology Letters 2017 22:25

    Content type: Short report

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  16. Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The study aimed to explore the potential role of heat shock protein 27 (HSP27) in the pathogenesis of TAD using an in vitro model of ...

    Authors: Sili Zou, Mingfang Liao, Junlin Yang, Tong Huang, Mark Green, Jianjin Wu and Lefeng Qu

    Citation: Cellular & Molecular Biology Letters 2017 22:24

    Content type: Research

    Published on:

  17. Hypoxic conditions induce the expression of hypoxia-inducible factors (HIFs) that allow cells to adapt to the changing conditions and alter the expression of a number of genes including the cystic fibrosis tra...

    Authors: Sylwia Bartoszewska, Wojciech Kamysz, Bogdan Jakiela, Marek Sanak, Jarosław Króliczewski, Zsuzsa Bebok, Rafal Bartoszewski and James F. Collawn

    Citation: Cellular & Molecular Biology Letters 2017 22:23

    Content type: Research article

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  18. TGF-β1 plays an important role in the epithelial–mesenchymal transition (EMT) of epithelial cancers, including non-small cell lung cancer (NSCLC). While the full underlying mechanism remains unclear, miR-9 is ...

    Authors: Hui Wang, Qian Wu, Ying Zhang, Hua-Nan Zhang, Yong-Bin Wang and Wei Wang

    Citation: Cellular & Molecular Biology Letters 2017 22:22

    Content type: Research

    Published on:

  19. Our previous study found that single-pass membrane protein with coiled-coil domains 1 (C3orf43; XM_006248472.3) was significantly upregulated in the proliferative phase during liver regeneration. This indicate...

    Authors: Chunyan Zhang, Cuifang Chang, Deming Li, Fuchun Zhang and Cunshuan Xu

    Citation: Cellular & Molecular Biology Letters 2017 22:21

    Content type: Short report

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  20. Clinicians use clinical and pathological parameters, such as tumour size, grade and nodal status, to make decisions on adjuvant treatments for breast cancer. However, therapeutic decisions based on these featu...

    Authors: Umar Wazir, Kinan Mokbel, Amtul Carmichael and Kefah Mokbel

    Citation: Cellular & Molecular Biology Letters 2017 22:20

    Content type: Mini review

    Published on:

  21. One of the microorganisms from dental plaque associated with severe inflammatory responses in infectious endocarditis is Porphyromonas gingivalis. It is a Gram-negative bacteria harvested from chronic periodontit...

    Authors: Gloria Gutiérrez-Venegas, Alfredo Torras-Ceballos, Juan Arturo Gómez-Mora and Berenice Fernández-Rojas

    Citation: Cellular & Molecular Biology Letters 2017 22:19

    Content type: Research

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  22. In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly of DNA-protein complex, ch...

    Authors: Sergey V. Razin and Sergey V. Ulianov

    Citation: Cellular & Molecular Biology Letters 2017 22:18

    Content type: Review

    Published on:

  23. Retinoblastoma (RB), a childhood cancer, is caused by biallelic mutation of the RB1 gene, but its development is not clearly understood. Furthermore, the presence of a cancer stem cell subpopulation in RB might i...

    Authors: Suganya Sivagurunathan, Jayamuruga Pandian Arunachalam and Subbulakshmi Chidambaram

    Citation: Cellular & Molecular Biology Letters 2017 22:17

    Content type: Short report

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  24. Nur-77, a member of the NR4A sub-family of nuclear orphan receptors, is downregulated in the placentae of pre-eclamptic women. Here, we investigate the relevance of Nor-1, Nurr-1 and Nur-77 in trophoblastic ce...

    Authors: Sudha Saryu Malhotra and Satish Kumar Gupta

    Citation: Cellular & Molecular Biology Letters 2017 22:15

    Content type: Short report

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  25. Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs ...

    Authors: Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong and Zhaochen Shan

    Citation: Cellular & Molecular Biology Letters 2017 22:14

    Content type: Research

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  26. FFA1 is abundantly expressed in the liver, skeletal muscle, monocytes and nervous system, but is particularly abundant in pancreatic β cells. It is widely believed that FFA1 exerts its regulatory roles in a va...

    Authors: Jing Qian, Yuyang Gu, Chun Wu, Feng Yu, Yuqi Chen, Jingmei Zhu, Xingyi Yao, Chen Bei and Qingqing Zhu

    Citation: Cellular & Molecular Biology Letters 2017 22:13

    Content type: Research

    Published on:

  27. MicroRNAs (miRNAs) play important roles in the growth and metastasis of colon cancer. It is known that one set of miRNAs are dysregulated in colon cancer cells, but the mechanism of their role in cancer develo...

    Authors: Mingxi Zeng, Linlin Zhu, Liangping Li and Changming Kang

    Citation: Cellular & Molecular Biology Letters 2017 22:12

    Content type: Research

    Published on:

  28. Human milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to proteins, lipids, carbohydrates and other biologically active components, breast milk contain...

    Authors: Malgorzata Witkowska-Zimny and Ewa Kaminska-El-Hassan

    Citation: Cellular & Molecular Biology Letters 2017 22:11

    Content type: Review

    Published on:

  29. H19 is a well-characterized Long noncoding RNA (lncRNA) that has been proven to promote myoblast differentiation in humans and mice. However, its mechanism of action is still not fully interpreted.

    Authors: Xiaochun Xu, Shengyue Ji, Weili Li, Bao Yi, Hengxin Li, Hongfu Zhang and Wenping Ma

    Citation: Cellular & Molecular Biology Letters 2017 22:10

    Content type: Short report

    Published on:

  30. The gene that encodes tumor protein p53, Tp53, is mutated or silenced in most human cancers and is recognized as one of the most important cancer drivers. Homozygotic Tp53 knockout mice, which develop lethal canc...

    Authors: Damian Strzemecki, Magdalena Guzowska and Paweł Grieb

    Citation: Cellular & Molecular Biology Letters 2017 22:9

    Content type: Short report

    Published on:

  31. Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggr...

    Authors: Zakir Khan, Abdul Arif Khan, Hariom Yadav, Godavarthi B. K. S. Prasad and Prakash Singh Bisen

    Citation: Cellular & Molecular Biology Letters 2017 22:8

    Content type: Review

    Published on:

  32. Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists. It is caused by inactivating mutat...

    Authors: Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino and Faustino Bisaccia

    Citation: Cellular & Molecular Biology Letters 2017 22:7

    Content type: Short Report

    Published on:

  33. Although the 3T3-L1 preadipocyte cell line represents an informative model for in vitro adipogenesis research, primary cultured cells are often needed to understand particular human or animal metabolic phenotypes...

    Authors: Yong Pu and Almudena Veiga-Lopez

    Citation: Cellular & Molecular Biology Letters 2017 22:6

    Content type: Short report

    Published on:

  34. Human Tenon’s fibroblasts (HTFs) play a crucial role in wound healing. They cause postoperative scarring of the filtering bleb and are thus responsible for trabeculectomy failure. This study aimed to find an e...

    Authors: Agata Przekora, Tomasz Zarnowski and Grazyna Ginalska

    Citation: Cellular & Molecular Biology Letters 2017 22:5

    Content type: Research

    Published on:

  35. Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), is a surface type I transmembrane core proteoglycan that is crucially involved in cell survival, migration and angiogene...

    Authors: Emmanuel Ampofo, Beate M. Schmitt, Michael D. Menger and Matthias W. Laschke

    Citation: Cellular & Molecular Biology Letters 2017 22:4

    Content type: Mini review

    Published on:

  36. Atherosclerosis is a chronically inflammatory disease and one of the leading causes of deaths worldwide. Endothelial cell apoptosis plays a crucial role in its development. Several microRNAs (miRNAs) are repor...

    Authors: Ying Li, Chunyan Yang, Lili Zhang and Ping Yang

    Citation: Cellular & Molecular Biology Letters 2017 22:3

    Content type: Research

    Published on:

  37. PU box-binding protein (PU.1) is a master gene of hematopoietic lineage and an important specific transcription factor in osteoclast lineage. There is proof of its expression in adipose tissue, and it is known...

    Authors: ChongMei Ruan, Xiu Li, JunJie Hu, Yong Zhang and XingXu Zhao

    Citation: Cellular & Molecular Biology Letters 2017 22:2

    Content type: Short report

    Published on:

  38. The harmful side effects of electroporation to cells due to local changes in pH, the appearance of toxic electrode products, temperature increase, and the heterogeneity of the electric field acting on cells in...

    Authors: Maciej Grys, Zbigniew Madeja and Włodzimierz Korohoda

    Citation: Cellular & Molecular Biology Letters 2017 22:1

    Content type: Research

    Published on:

  39. The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body...

    Authors: Wei Jing Liu, Lin Ye, Wei Fang Huang, Lin Jie Guo, Zi Gan Xu, Hong Luan Wu, Chen Yang and Hua Feng Liu

    Citation: Cellular & Molecular Biology Letters 2016 21:29

    Content type: Mini review

    Published on:

  40. Immunoglobulin G (IgG) has been implicated in the progression of various cancers. This study explored the role of IgG in the proliferation, apoptosis, cell cycle and in vitro invasive properties of LNCaP prost...

    Authors: Yawen Xu, Binshen Chen, Shaobo Zheng, Yong Wen, Abai Xu, Kai Xu, Bingkun Li and Chunxiao Liu

    Citation: Cellular & Molecular Biology Letters 2016 21:27

    Content type: Short report

    Published on:

  41. Cytoglobin (CYGB), a member of the globin family, is thought to protect cells from reactive oxygen and nitrogen species and deal with hypoxic conditions and oxidative stress. However, its molecular mechanisms ...

    Authors: Xin Li, Shanshan Zou, Zhen Li, Gaotai Cai, Bohong Chen, Ping Wang and Wenqi Dong

    Citation: Cellular & Molecular Biology Letters 2016 21:25

    Content type: Short communication

    Published on:

  42. Synonymous or silent mutations are often overlooked in genetic analyses for disease-causing mutations unless they are directly associated with potential splicing defects. More recent studies, however, indicate...

    Authors: Rafal Bartoszewski, Jaroslaw Króliczewski, Arkadiusz Piotrowski, Anna Janaszak Jasiecka, Sylwia Bartoszewska, Briana Vecchio-Pagan, Lianwu Fu, Aleksandra Sobolewska, Sadis Matalon, Garry R. Cutting, Steven M. Rowe and James F. Collawn

    Citation: Cellular & Molecular Biology Letters 2016 21:23

    Content type: Review

    Published on:

  43. How nutrition and growth factor restriction due to serum depletion affect trophoblast function remains poorly understood. We performed a proteomic differential study of the effects of serum depletion on a firs...

    Authors: Susana Novoa-Herran, Adriana Umaña-Perez, Francesc Canals and Myriam Sanchez-Gomez

    Citation: Cellular & Molecular Biology Letters 2016 21:22

    Content type: Research article

    Published on:

  44. Long non-coding RNAs (lncRNAs) play critical and complicated roles in the regulation of various biological processes, including chromatin modification, transcription and post-transcriptional processing. Intere...

    Authors: Jiachun Sun, Junqiang Yan, Xiaozhi Yuan, Ruina Yang, Tanyou Dan, Xinshuai Wang, Guoqiang Kong and Shegan Gao

    Citation: Cellular & Molecular Biology Letters 2016 21:21

    Content type: Short report

    Published on:

  45. As a key subunit of the exocyst complex, Exo70 has highly conserved sequence and is widely found in yeast, mammals, and plants. In yeast, Exo70 mediates the process of exocytosis and promotes anchoring and int...

    Authors: Wenqing Ma, Yu Wang, Xiaomeng Yao, Zijian Xu, Liguo An and Miao Yin

    Citation: Cellular & Molecular Biology Letters 2016 21:20

    Content type: Short report

    Published on:

  46. Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and function with other BAG family members. Functioning as a co-chaperone, it interacts with the ATPase domain of the heat shock protein...

    Authors: Lixia Qin, Jifeng Guo, Qian Zheng and Hainan Zhang

    Citation: Cellular & Molecular Biology Letters 2016 21:18

    Content type: Mini Review

    Published on:

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