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  1. Research on aging is growing as the elderly make up a greater share of the population, focusing on reversing and inhibiting the aging process. The exhaustion and senescence of stem cells are the fundamental dr...

    Authors: Wei V. Zheng, Wang Xu, Yaqin Li, Jie Qin, Tao Zhou, Dezhi Li, Yanwei Xu, Xianyi Cheng, Yu Xiong and Zaizhong Chen
    Citation: Cellular & Molecular Biology Letters 2022 27:86
    Content type: Research Published on:

  2. Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) ...

    Authors: Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo and Guokun Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:85
    Content type: Research Published on:

  3. Long noncoding RNAs are involved in epigenetic gene modification, including binding to the chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in gene expression regulation,...

    Authors: Ruiming Li, Xia Wang, Chunming Zhu and Kefeng Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:84
    Content type: Review Published on:

  4. Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migrat...

    Authors: Abdulwahab Teflischi Gharavi, Niloofar Asadi Hanjani, Elaheh Movahed and Mohammad Doroudian
    Citation: Cellular & Molecular Biology Letters 2022 27:83
    Content type: Review Letter Published on:

  5. Influenza-related acute lung injury (ALI) is a life-threatening condition that results mostly from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses. The methoxy flavonoid c...

    Authors: Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li and Beixian Zhou
    Citation: Cellular & Molecular Biology Letters 2022 27:82
    Content type: Research Published on:

  6. CDGSH iron sulfur domain 2 (CISD2) is an iron–sulfur protein with a [2Fe–2S] cluster, which is critical for cell proliferation and iron homeostasis. It has been demonstrated that aberrant expression of CISD2 i...

    Authors: Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang and Jing Du
    Citation: Cellular & Molecular Biology Letters 2022 27:81
    Content type: Research Letter Published on:

  7. Extensive inflammation of endothelial cells (ECs) facilitates atherosclerotic lesion formation. Circular RNA (circRNA) participates in atherosclerosis (AS)-related inflammation responses; however, whether and ...

    Authors: Min Zhang, Yiqian Zhu, Jie Zhu, Yi Xie, Ruihao Wu, JiaYin Zhong, Zhaohui Qiu and Li Jiang
    Citation: Cellular & Molecular Biology Letters 2022 27:80
    Content type: Research Published on:

  8. MicroRNAs (miRNAs) play crucial roles in the development of hepatocellular carcinoma (HCC). Hsa-microRNA-27b-3p (hsa-miR-27b) is involved in the formation and progression of various cancers, but its role and clin...

    Authors: Jingyuan Wen, Zhao Huang, Yi Wei, Lin Xue, Yufei Wang, Jingyu Liao, Junnan Liang, Xiaoping Chen, Liang Chu and Bixiang Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:79
    Content type: Research Published on:

  10. Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as ...

    Authors: Irene Lee-Rivera, Edith López and Ana María López-Colomé
    Citation: Cellular & Molecular Biology Letters 2022 27:77
    Content type: Review Letter Published on:

  11. Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no biomarker capable of evaluating the hypoxic stat...

    Authors: Jie-pin Li, Yuan-jie Liu, Shu-hong Zeng, Hai-jian Gao, Yu-gen Chen and Xi Zou
    Citation: Cellular & Molecular Biology Letters 2022 27:76
    Content type: Research Published on:

  12. Ulcerative colitis-associated colorectal cancer (UC-CRC) is an important complication of ulcerative colitis. Pou3f1 (POU class 3 homeobox 1) is a critical regulator for developmental events and cellular biolog...

    Authors: Yan Lin, Dongxu Wang, Hong Zhao, Dongyue Li, Xinning Li and Lianjie Lin
    Citation: Cellular & Molecular Biology Letters 2022 27:75
    Content type: Research Published on:

  13. Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered particles are naturally released into...

    Authors: Mohsen Karami Fath, Jalil Azami, Niloofar Jaafari, Mahsa Akbari Oryani, Nafiseh Jafari, Alireza Karim poor, Ali Azargoonjahromi, Mohsen Nabi-Afjadi, Zahra Payandeh, Hamidreza Zalpoor and Dariush Shanehbandi
    Citation: Cellular & Molecular Biology Letters 2022 27:74
    Content type: Review Published on:

  14. Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated biological effects include the regulation of circadian rhythms, which is important for optimal human health. Also, melatonin...

    Authors: Amirhossein Davoodvandi, Banafsheh Nikfar, Russel J. Reiter and Zatollah Asemi
    Citation: Cellular & Molecular Biology Letters 2022 27:73
    Content type: Review Letter Published on:

  15. Osteoporotic fractures lead to increased disability and mortality in the elderly population. With the rapid increase in the aging population around the globe, more effective treatments for osteoporosis and ost...

    Authors: Bo Liang, George Burley, Shu Lin and Yan-Chuan Shi
    Citation: Cellular & Molecular Biology Letters 2022 27:72
    Content type: Review Letter Published on:

  16. N-Acetylgalactosaminyltransferases (GALNTs), the enzymes that initiate mucin-type O-glycosylation, are closely associated with tumor occurrence and progression. However, a comprehensive analysis of GALNTs in non-...

    Authors: Qing Hu, Tian Tian, Yahui Leng, Yuanhui Tang, Shuang Chen, Yueyao Lv, Jingyin Liang, Yanni Liu, Tianhui Liu, Li Shen and Xiaoxia Dong
    Citation: Cellular & Molecular Biology Letters 2022 27:71
    Content type: Research Published on:

  18. Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tiss...

    Authors: Mahmoud Al-Azab, Mohammed Safi, Elina Idiiatullina, Fadhl Al-Shaebi and Mohamed Y. Zaky
    Citation: Cellular & Molecular Biology Letters 2022 27:69
    Content type: Review Published on:

  19. Authors: Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Daoyin Gong, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu and Zhuo Xu
    Citation: Cellular & Molecular Biology Letters 2022 27:68
    Content type: Correction Published on:

    The original article was published in Cellular & Molecular Biology Letters 2022 27:61

  21. Sestrin2 (SESN2), a stress-inducible protein, has been reported to protect against denervated muscle atrophy through unfolded protein response and mitophagy, while its role in myofiber type transition remains unk...

    Authors: Xiaofan Yang, Pingping Xue, Zhenyu Liu, Wenqing Li, Chuyan Li and Zhenbing Chen
    Citation: Cellular & Molecular Biology Letters 2022 27:66
    Content type: Research Published on:

  22. Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for patients. Gliomas are principally characterized by rapid diffusion as well as high levels ...

    Authors: Alireza Mafi, Atefe Rahmati, Zahra Babaei Aghdam, Raziyeh Salami, Marziyeh Salami, Omid Vakili and Esmat Aghadavod
    Citation: Cellular & Molecular Biology Letters 2022 27:65
    Content type: Review Published on:

  23. Progranulin (PGRN) is an autocrine growth factor that regulates cell proliferation, migration, wound healing, and tissue repair in mammals. Lamprey is the most primitive of the extant vertebrates and is regard...

    Authors: Ruixiang Sun, Dong Wang, Yuxuan Song, Qingwei Li, Peng Su and Yue Pang
    Citation: Cellular & Molecular Biology Letters 2022 27:64
    Content type: Research Letter Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2022 27:96

  24. The pandemic outbreak of coronavirus disease 2019 (COVID-19) has created health challenges in all parts of the world. Understanding the entry mechanism of this virus into host cells is essential for effective ...

    Authors: Fahimeh Zamani Rarani, Mohammad Zamani Rarani, Michael R. Hamblin, Bahman Rashidi, Seyed Mohammad Reza Hashemian and Hamed Mirzaei
    Citation: Cellular & Molecular Biology Letters 2022 27:63
    Content type: Review Published on:

  25. Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment with artemisinin (AT) d...

    Authors: Jin Li, Mengqing Jiang, Zhentang Yu, Chenwei Xiong, Jieen Pan, Zhenhai Cai, Nanwei Xu, Xindie Zhou, Yong Huang and Zhicheng Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:62
    Content type: Research Published on:

  26. Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its efficacy. Borneol may promote drug absorption; however, synergism betwee...

    Authors: Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Daoyin Gong, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu and Zhuo Xu
    Citation: Cellular & Molecular Biology Letters 2022 27:61
    Content type: Research Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2022 27:68

  27. The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammat...

    Authors: Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Chanour Tavakol, Faranak Farahighasreaboonasr, Farid Pakizeh, Vahid Ghobadi Dana and Farhad Seif
    Citation: Cellular & Molecular Biology Letters 2022 27:60
    Content type: Review Letter Published on:

  28. Previously, we reported the expression of DLX4 isoforms (BP1 and DLX7) in myeloid leukemia, but the functional role of DLX4 isoforms remains poorly understood. In the work described herein, we further determined ...

    Authors: Jing-dong Zhou, Yang-jing Zhao, Jia-yan Leng, Yu Gu, Zi-jun Xu, Ji-chun Ma, Xiang-mei Wen, Jiang Lin, Ting-juan Zhang and Jun Qian
    Citation: Cellular & Molecular Biology Letters 2022 27:59
    Content type: Research Letter Published on:

  29. Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodi...

    Authors: Samaneh Mostafavi, Hamidreza Zalpoor and Zuhair Mohammad Hassan
    Citation: Cellular & Molecular Biology Letters 2022 27:58
    Content type: Review Letter Published on:

  30. Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently to exert an outstanding protective effect on multiple organ injury, including acute kidney injury (AKI). In this study, we aim to s...

    Authors: Shankun Zhao, Weizhou Wu, Jian Liao, Xinsheng Zhang, Maolei Shen, Xin Li, Qi Lin and Chaoliang Cao
    Citation: Cellular & Molecular Biology Letters 2022 27:57
    Content type: Review Letter Published on:

  31. Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a myriad of studies in animal models and ...

    Authors: Mohaddeseh Rahbaran, Angelina Olegovna Zekiy, Mahta Bahramali, Mohammadsaleh Jahangir, Mahsa Mardasi, Delaram Sakhaei, Lakshmi Thangavelu, Navid Shomali, Majid Zamani, Ali Mohammadi and Negin Rahnama
    Citation: Cellular & Molecular Biology Letters 2022 27:56
    Content type: Review Published on:

  32. METTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a role during angiotensin II (Ang-II)-induced myocardial hypertrophy is...

    Authors: Rui Zhang, Yangyang Qu, Zhenjun Ji, Chunshu Hao, Yamin Su, Yuyu Yao, Wenjie Zuo, Xi Chen, Mingming Yang and Genshan Ma
    Citation: Cellular & Molecular Biology Letters 2022 27:55
    Content type: Research Published on:

  34. Organoids, which are organs grown in a dish from stem or progenitor cells, model the structure and function of organs and can be used to define molecular events during organ formation, model human disease, ass...

    Authors: Kate Tubbesing, Nicholas Moskwa, Ting Chean Khoo, Deirdre A. Nelson, Anna Sharikova, Yunlong Feng, Melinda Larsen and Alexander Khmaladze
    Citation: Cellular & Molecular Biology Letters 2022 27:53
    Content type: Research Published on:

  35. Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is the most important factor giving rise to this malignancy. The most not...

    Authors: Mohsen Karami Fath, Ali Azargoonjahromi, Arash Kiani, Fateme Jalalifar, Parisa Osati, Mahsa Akbari Oryani, Fateh Shakeri, Farhad Nasirzadeh, Behman Khalesi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Maysam Mard-Soltani and Zahra Payandeh
    Citation: Cellular & Molecular Biology Letters 2022 27:52
    Content type: Review Published on:

  36. Diabetic nephropathy (DN) is prevalent in patients with diabetes. N6-methyladenosine (m6A) methylation has been found to cause modification of nucleotide-binding oligomerization domain, leucine-rich repeat, and p...

    Authors: Jianzi Lan, Bowen Xu, Xin Shi, Qi Pan and Qing Tao
    Citation: Cellular & Molecular Biology Letters 2022 27:51
    Content type: Research Published on:

  37. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), a major international public health concern. Because of very similar amino acid sequences of th...

    Authors: Mohammadreza Saberiyan, Elham Karimi, Zahra Khademi, Parvaneh Movahhed, Amir Safi and Ameneh Mehri-Ghahfarrokhi
    Citation: Cellular & Molecular Biology Letters 2022 27:50
    Content type: Review Letter Published on:

  38. The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, includ...

    Authors: Mostafa Vaghari-Tabari, Parisa Hassanpour, Fatemeh Sadeghsoltani, Faezeh Malakoti, Forough Alemi, Durdi Qujeq, Zatollah Asemi and Bahman Yousefi
    Citation: Cellular & Molecular Biology Letters 2022 27:49
    Content type: Review Published on:

  39. Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is urgent to find novel therapy strategies to overcome this feature. Metformin has been confirmed to suppress invasion...

    Authors: Dong Suwei, Xiao Yanbin, Wang Jianqiang, Ma Xiang, Peng Zhuohui, Kang Jianping, Wang Yunqing and Li Zhen
    Citation: Cellular & Molecular Biology Letters 2022 27:48
    Content type: Research Letter Published on:

  40. Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of noncoding RNAs,...

    Authors: Jian-Zhi Zhao, Qi-Yao Li, Jia-Jie Lin, Li-Yun Yang, Mei-Yang Du, Yu Wang, Ke-Xin Liu, Ze-An Jiang, Huan-Huan Li, Si-Fan Wang, Bo Sun, Shi-Qing Mu, Bin Li, Kun Liu, Miao Gong and Shao-Guang Sun
    Citation: Cellular & Molecular Biology Letters 2022 27:47
    Content type: Research Letter Published on:

  41. The submandibular gland (SMG) and the sublingual gland (SLG) are two of the three major salivary glands in mammals. In mice, they are adjacent to each other and open into the oral cavity, producing saliva to l...

    Authors: Wenping Luo, Panpan Liang, Tianyu Zhao, Qianyu Cheng, Huikai Liu, Liwen He, Linghuan Zhang, Bo Huang, Yuxin Zhang, Tongchuan He and Deqin Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:46
    Content type: Research Published on:

  42. Cancer-associated fibroblasts (CAFs) have been shown to support tumor development in a variety of cancers. Different markers were applied to classify CAFs in order to elucidate their impact on tumor progressio...

    Authors: Anna Muchlińska, Anna Nagel, Marta Popęda, Jolanta Szade, Magdalena Niemira, Jacek Zieliński, Jarosław Skokowski, Natalia Bednarz-Knoll and Anna J. Żaczek
    Citation: Cellular & Molecular Biology Letters 2022 27:45
    Content type: Research Letter Published on:

  43. Obstructive sleep apnea is associated with increased lung cancer incidence and mortality. Cancer stem cells (CSCs) are characterized by their self-renewing ability, which contributes to metastasis, recurrence,...

    Authors: Shengyu Hao, Fan Li, Pan Jiang and Jian Gao
    Citation: Cellular & Molecular Biology Letters 2022 27:44
    Content type: Research Letter Published on:

  44. The pivotal role of long noncoding RNAs (lncRNAs) in cancer immune responses has been well established. This study was conducted with the aim of exploring the molecular mechanism of lncRNA small nucleolar RNA ...

    Authors: Yusheng Huang, Lei Xia, Xiangwu Tan, Jingyi Zhang, Weiwei Zeng, Benxu Tan, Xian Yu, Wei Fang and Zhenzhou Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:43
    Content type: Research Published on:

  45. The appearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its spread all over the world is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has recently resulted in...

    Authors: Lucyna Matusewicz, Marlena Golec, Aleksander Czogalla, Kazimierz Kuliczkowski, Adam Konka, Joanna Zembala-John and Aleksander F. Sikorski
    Citation: Cellular & Molecular Biology Letters 2022 27:42
    Content type: Review Letter Published on:

  46. The molecular mechanisms driving hepatocellular carcinoma (HCC) remain largely unclear. As one of the major epitranscriptomic modifications, N6-methyladenosine (m6A) plays key roles in HCC. The aim of this study ...

    Authors: Yun-zhang Dai, Yong-da Liu, Jie Li, Mei-ting Chen, Mei Huang, Fang Wang, Qing-song Yang, Ji-hang Yuan and Shu-han Sun
    Citation: Cellular & Molecular Biology Letters 2022 27:41
    Content type: Research Published on:

  47. In patients with acute aortic dissection (AAD), increased vascular smooth muscle cell (VSMC) apoptosis has been found. Human cytomegalovirus (HCMV)-miR-US33-5p was significantly increased in the plasma of pati...

    Authors: Jian Dong, Shuangshuang Li, Zilin Lu, Pengcheng Du, Guangqin Liu, Mintao Li, Chao Ma, Jian Zhou and Junmin Bao
    Citation: Cellular & Molecular Biology Letters 2022 27:40
    Content type: Research Published on:

  48. Esophageal squamous cell carcinoma (ESCC) is correlated with worse clinical prognosis and lacks available targeted therapy. Thus, identification of reliable biomarkers is required for the diagnosis and treatme...

    Authors: Jinfeng Zhang, Xiaodong Ling, Chengyuan Fang and Jianqun Ma
    Citation: Cellular & Molecular Biology Letters 2022 27:39
    Content type: Research Published on:

  49. Designing and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 (COVID-19) pandemic, many large pharmaceutical and biotec...

    Authors: Armina Alagheband Bahrami, Ali Azargoonjahromi, Samin Sadraei, Aryan Aarabi, Zahra Payandeh and Masoumeh Rajabibazl
    Citation: Cellular & Molecular Biology Letters 2022 27:38
    Content type: Review Published on:

  50. RING finger protein 7 (RNF7) is a highly conserved protein that functions as an E3 ubiquitin ligase. RNF7 overexpression is indicated in multiple human cancers, but its role in renal cell carcinoma (RCC) and t...

    Authors: Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang and Qing Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:36
    Content type: Research Published on:

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