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  1. Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription fact...

    Authors: Dazhi Fu, Chunxiao Wang, Lei Yu and Rui Yu
    Citation: Cellular & Molecular Biology Letters 2021 26:26
    Content type: Research Published on:

  2. Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNA...

    Authors: Xuan Xiong, Changchun Liu, Meiren Shen, Qian Yang, Qiang Zhao, Xiaoyan Li, Xiaoshi Zhong and Zhiwei Wang
    Citation: Cellular & Molecular Biology Letters 2021 26:25
    Content type: Research Letter Published on:

  3. The suppressive effects of miR-33a-5p have been reported in colorectal cancer and lung cancer. However, the functional role of miR-33a-5p in pancreatic ductal adenocarcinoma (PDAC) has not yet been elucidated.

    Authors: Yanfen Lian, Dongxiao Jiang and Jiangtao Sun
    Citation: Cellular & Molecular Biology Letters 2021 26:24
    Content type: Research Published on:

  4. Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This stu...

    Authors: Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo and Jin Wang
    Citation: Cellular & Molecular Biology Letters 2021 26:23
    Content type: Research Letter Published on:

  5. Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differ...

    Authors: Xiaozhong Zhou, Wangyang Xu, Yeyang Wang, Hui Zhang, Li Zhang, Chao Li, Shun Yao, Zixiang Huang, Lishan Huang and Dixin Luo
    Citation: Cellular & Molecular Biology Letters 2021 26:22
    Content type: Research Published on:

  6. Recently, pivotal functions of miRNAs in regulating common tumorigenic processes and manipulating signaling pathways in brain tumors have been recognized; notably, miR‐29a is closely associated with p53 signal...

    Authors: Qiudan Chen, Weifeng Wang, Shuying Chen, Xiaotong Chen and Yong Lin
    Citation: Cellular & Molecular Biology Letters 2021 26:21
    Content type: Research Letter Published on:

  8. Some natural compounds inhibit cancer cell growth in various cancer cell lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological effects and mechanisms of worenine (is...

    Authors: Lijiang Ji, Weixing Shen, Feng Zhang, Jie Qian, Jie Jiang, Liping Weng, Jiani Tan, Liu Li, Yugen Chen, Haibo Cheng and Dongdong Sun
    Citation: Cellular & Molecular Biology Letters 2021 26:19
    Content type: Research Letter Published on:

  9. Mammalian/mechanistic target of rapamycin (mTOR) complexes are essential for cell proliferation, growth, differentiation, and survival. mTORC1 hyperactivation occurs in the tuberous sclerosis complex (TSC). mT...

    Authors: Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska and Jacek Jaworski
    Citation: Cellular & Molecular Biology Letters 2021 26:18
    Content type: Research Letter Published on:

  10. Most currently recommended therapies for metabolic dysfunction-associated fatty liver disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and compiled the most recent research into po...

    Authors: Jianan Zhao, Yiyang Hu and Jinghua Peng
    Citation: Cellular & Molecular Biology Letters 2021 26:17
    Content type: Review Published on:

  11. In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas G...

    Authors: Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan and Hiroaki Konishi
    Citation: Cellular & Molecular Biology Letters 2021 26:16
    Content type: Research Letter Published on:

  12. Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintenance of cell shape, and material transport.

    Authors: Bing Sun, Rongmei Qu, Tingyu Fan, Yuchao Yang, Xin Jiang, Asmat Ullah Khan, Zhitao Zhou, Jingliao Zhang, Kuanhai Wei, Jun Ouyang and Jingxing Dai
    Citation: Cellular & Molecular Biology Letters 2021 26:15
    Content type: Research Published on:

  13. The expression signature of deregulated long non-coding RNAs (lncRNAs) and related genetic variants is implicated in every stage of tumorigenesis, progression, and recurrence. This study aimed to explore the a...

    Authors: Shahad W. Kattan, Yahya H. Hobani, Sameerah Shaheen, Sara H. Mokhtar, Mohammad H. Hussein, Eman A. Toraih, Manal S. Fawzy and Hussein Abdelaziz Abdalla
    Citation: Cellular & Molecular Biology Letters 2021 26:14
    Content type: Research Published on:

  16. Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell surv...

    Authors: Sylwia Bartoszewska, Jarosław Króliczewski, David K. Crossman, Aneta Pogorzelska, Maciej Bagiński, James F. Collawn and Rafal Bartoszewski
    Citation: Cellular & Molecular Biology Letters 2021 26:11
    Content type: Research Published on:

  17. Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation...

    Authors: Marcin Woźniak, Christian J. Konopka, Agata Płoska, Jamila Hedhli, Anna Siekierzycka, Maciej Banach, Rafal Bartoszewski, Lawrence W. Dobrucki, Leszek Kalinowski and Iwona T. Dobrucki
    Citation: Cellular & Molecular Biology Letters 2021 26:10
    Content type: Research Letter Published on:

  18. Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating d...

    Authors: Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang and Lining Wei
    Citation: Cellular & Molecular Biology Letters 2021 26:9
    Content type: Research Letter Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2023 28:29

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2021 26:55

  19. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s11658-021-00252-1

    Authors: Yan Hao, Haitao Yuan and Houzhi Yu
    Citation: Cellular & Molecular Biology Letters 2021 26:8
    Content type: Retraction Note Published on:

    The original article was published in Cellular & Molecular Biology Letters 2020 25:20

  20. NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4+ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4+IL22+IFNγ−IL17A−) cells are a subgroup o...

    Authors: Chong Zeng, Zhongbao Shao, Zibo Wei, Jie Yao, Weidong Wang, Liang Yin, Huixian YangOu and Dan Xiong
    Citation: Cellular & Molecular Biology Letters 2021 26:7
    Content type: Research Letter Published on:

  21. ZNF674-AS1, a recently characterized long noncoding RNA, shows prognostic significance in hepatocellular carcinoma and glioma. However, the expression and function of ZNF674-AS1 in non-small cell lung cancer (...

    Authors: Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin and Liangcheng Zheng
    Citation: Cellular & Molecular Biology Letters 2021 26:6
    Content type: Research Published on:

  22. The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B and SV2C are implicated in neurological dise...

    Authors: Emilia Lekholm, Mikaela M. Ceder, Erica C. Forsberg, Helgi B. Schiöth and Robert Fredriksson
    Citation: Cellular & Molecular Biology Letters 2021 26:5
    Content type: Research Letter Published on:

  23. miRNAs are well known to be gene repressors. A newly identified class of miRNAs termed nuclear activating miRNAs (NamiRNAs), transcribed from miRNA loci that exhibit enhancer features, promote gene expression ...

    Authors: Emmanuel Odame, Yuan Chen, Shuailong Zheng, Dinghui Dai, Bismark Kyei, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li and Hongping Zhang
    Citation: Cellular & Molecular Biology Letters 2021 26:4
    Content type: Review Published on:

  24. Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppre...

    Authors: Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu and Xuerong Chen
    Citation: Cellular & Molecular Biology Letters 2021 26:3
    Content type: Review Published on:

  25. Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcu...

    Authors: Shujuan Zhou, Lan Sun, Shanhu Qian, Yongyong Ma, Ruye Ma, Yuqing Dong, Yifen Shi, Songfu Jiang, Haige Ye, Zhijian Shen, Shenghui Zhang, Jianping Shen, Kang Yu and Siqian Wang
    Citation: Cellular & Molecular Biology Letters 2021 26:2
    Content type: Research Published on:

  26. Protein ubiquitination has become one of the most extensively studied post-translational modifications. Originally discovered as a critical element in highly regulated proteolysis, ubiquitination is now regard...

    Authors: Michal Tracz and Wojciech Bialek
    Citation: Cellular & Molecular Biology Letters 2021 26:1
    Content type: Review Letter Published on:

  27. Human cardiac stem cells expressing the W8B2 marker (W8B2+ CSCs) were recently identified and proposed as a new model of multipotent CSCs capable of differentiating into smooth muscle cells, endothelial cells and...

    Authors: Oualid Ayad, Zeina R. Al Sayed, Stéphane Sebille, Christophe Magaud, Charles-Albert Chapotte-Baldacci, Christophe Jayle, Jean-François Faivre, Nathalie Gaborit, Aurélien Chatelier and Patrick Bois
    Citation: Cellular & Molecular Biology Letters 2020 25:50
    Content type: Research Letter Published on:

  28. To explore the effect of miR-296-5p on the metastasis of nasopharyngeal carcinoma (NPC) cells and investigate the underlying mechanism.

    Authors: Meihui Chen, Chen Chen, Haiqing Luo, Jing Ren, Qiuqin Dai, Wenjia Hu, Keyuan Zhou, Xudong Tang and Xiangyong Li
    Citation: Cellular & Molecular Biology Letters 2020 25:49
    Content type: Research Published on:

  30. Circular RNAs (circRNAs) are thought to be involved in the development of various malignancies. The expression and function of hsa_circ_0006916, a newly identified circRNA, in hepatocellular carcinoma remain u...

    Authors: Xiao-Yong Zhou, Hui Yang, Yang-Qiu Bai, Xiu-Ling Li, Shuang-Yin Han and Bing-Xi Zhou
    Citation: Cellular & Molecular Biology Letters 2020 25:47
    Content type: Research Published on:

  32. Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key mechanism in pulmonary arterial hypertension (PAH). Serotonin (5-hydroxytryptamine, 5-HT) can induce abnormal proliferation of P...

    Authors: Ying Zhang, Yongbin Chen, Guo Chen, Yingling Zhou, Hua Yao and Hong Tan
    Citation: Cellular & Molecular Biology Letters 2020 25:45
    Content type: Research Letter Published on:

  33. Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regu...

    Authors: Yi Fang and Zhen Zhang
    Citation: Cellular & Molecular Biology Letters 2020 25:44
    Content type: Review Letter Published on:

  34. Long intergenic non-protein coding RNA00665 (LINC00665) plays a crucial tumorigenic role in many cancers, such as gastric cancer and lung adenocarcinoma. However, its role and mechanism of action in the progre...

    Authors: Minhao Lv, Qixin Mao, Juntao Li, Jianghua Qiao, Xiuchun Chen and Suxia Luo
    Citation: Cellular & Molecular Biology Letters 2020 25:43
    Content type: Research Published on:

  35. Deer antlers have become a valuable model for biomedical research due to the capacities of regeneration and rapid growth. However, the molecular mechanism of rapid antler growth remains to be elucidated. The a...

    Authors: Baojin Yao, Chaonan Wang, Zhenwei Zhou, Mei Zhang, Daqing Zhao, Xueyuan Bai and Xiangyang Leng
    Citation: Cellular & Molecular Biology Letters 2020 25:42
    Content type: Research Letter Published on:

  36. The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in t...

    Authors: Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp and Borivoj Vojtesek
    Citation: Cellular & Molecular Biology Letters 2020 25:41
    Content type: Research Published on:

  37. Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown...

    Authors: Kota Ogawa, Akiko Noda, Jun Ueda, Takehiro Ogata, Rumiko Matsuyama, Yuji Nishizawa, Shanlou Qiao, Satoru Iwata, Morihiro Ito, Yoshitaka Fujihara, Masatoshi Ichihara, Koichi Adachi, Yuji Takaoka and Takashi Iwamoto
    Citation: Cellular & Molecular Biology Letters 2020 25:40
    Content type: Research Published on:

  38. Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the anim...

    Authors: Shuhei Yamada
    Citation: Cellular & Molecular Biology Letters 2020 25:39
    Content type: Review Letter Published on:

  39. Daxx is a highly conserved nuclear protein with an important role in transcription, apoptosis and other cell processes. We investigated the role of HPV16 E6 in Daxx-induced apoptosis through their interactions...

    Authors: Shuangyang Tang, Shuang Ding, Lan Yu, Haiyan Shen, Yanping Wan and Yimou Wu
    Citation: Cellular & Molecular Biology Letters 2020 25:38
    Content type: Research Letter Published on:

  40. The plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical prope...

    Authors: Ambroise Wu, Karolina Wojtowicz, Stephane Savary, Yannick Hamon and Tomasz Trombik
    Citation: Cellular & Molecular Biology Letters 2020 25:37
    Content type: Invited Review Published on:

  41. Rhomboid domain containing 1 (RHBDD1) plays a crucial role in tumorigenesis. Silibinin, which is a natural extract from milk thistle, has shown anti-tumor effects against various tumors. Here, we investigate w...

    Authors: Suyan Xu, Hongyan Zhang, Aifeng Wang, Yongcheng Ma, Yuan Gan and Guofeng Li
    Citation: Cellular & Molecular Biology Letters 2020 25:36
    Content type: Research Letter Published on:

  42. One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associat...

    Authors: Agata Forkasiewicz, Maja Dorociak, Kamilla Stach, Piotr Szelachowski, Renata Tabola and Katarzyna Augoff
    Citation: Cellular & Molecular Biology Letters 2020 25:35
    Content type: Invited Review Letter Published on:

  44. Peritoneal fibrosis (PF) is a frequent complication caused by peritoneal dialysis (PD). Peritoneal mesothelial cells (PMCs), the first barrier of the peritoneum, play an important role in maintaining structure...

    Authors: Junyi Zhao, Jun Shi, Yun Shan, Manshu Yu, Xiaolin Zhu, Yilin Zhu, Li Liu and Meixiao Sheng
    Citation: Cellular & Molecular Biology Letters 2020 25:33
    Content type: Research Published on:

  45. Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well...

    Authors: Magdalena Przybyło and Marek Langner
    Citation: Cellular & Molecular Biology Letters 2020 25:32
    Content type: Invited Review Published on:

  46. Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a potent vasoconstrictor. Because of it...

    Authors: Duo-Yao Cao, Suguru Saito, Luciana C. Veiras, Derick Okwan-Duodu, Ellen A. Bernstein, Jorge F. Giani, Kenneth E. Bernstein and Zakir Khan
    Citation: Cellular & Molecular Biology Letters 2020 25:31
    Content type: Invited Review Letter Published on:

  47. Dysregulation of the proliferation and migration of vascular smooth muscle cells (VSMCs) is a crucial cause of atherosclerosis. MiR-637 exerts an antiproliferative effect on multiple human cells. Its impact on...

    Authors: Ning Yang, Bo Dong, Yanqiu Song, Yang Li, Lu Kou, Jingyu Yang and Qin Qin
    Citation: Cellular & Molecular Biology Letters 2020 25:30
    Content type: Research Letter Published on:

  48. Long non-coding RNA (lncRNA) as a widespread and pivotal epigenetic molecule participates in the occurrence and progression of malignant tumors. DRAIC, a kind of lncRNA whose coding gene location is on 15q23 c...

    Authors: Zheng Zhang, Xiaoxuan Hu, Jia Kuang, Jinmao Liao and Qi Yuan
    Citation: Cellular & Molecular Biology Letters 2020 25:29
    Content type: Research Published on:

  49. Adoptive T-cell therapy (ACT) using autologous tumor-reactive T lymphocytes has considerable potential for cancer immunotherapy. In ACT, T cells are isolated from cancer patients and then stimulated and expand...

    Authors: Salman Bagheri, Elmira Safaie Qamsari, Mehdi Yousefi, Farhad Riazi-Rad and Zahra Sharifzadeh
    Citation: Cellular & Molecular Biology Letters 2020 25:28
    Content type: Research Letter Published on:

  50. MicroRNA dysregulation occurs in many human diseases, including atherosclerosis. Here, we examined the serum expression and clinical significance of miR-186-5p in patients with atherosclerosis, and explored it...

    Authors: Bin Sun, Qingtao Cao, Meng Meng and Xiaolong Wang
    Citation: Cellular & Molecular Biology Letters 2020 25:27
    Content type: Research Letter Published on:

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