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  1. Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently to exert an outstanding protective effect on multiple organ injury, including acute kidney injury (AKI). In this study, we aim to s...

    Authors: Shankun Zhao, Weizhou Wu, Jian Liao, Xinsheng Zhang, Maolei Shen, Xin Li, Qi Lin and Chaoliang Cao
    Citation: Cellular & Molecular Biology Letters 2022 27:57
  2. Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a myriad of studies in animal models and ...

    Authors: Mohaddeseh Rahbaran, Angelina Olegovna Zekiy, Mahta Bahramali, Mohammadsaleh Jahangir, Mahsa Mardasi, Delaram Sakhaei, Lakshmi Thangavelu, Navid Shomali, Majid Zamani, Ali Mohammadi and Negin Rahnama
    Citation: Cellular & Molecular Biology Letters 2022 27:56
  3. METTL3 is the core catalytic enzyme in m6A and is involved in a variety of cardiovascular diseases. However, whether and how METTL3 plays a role during angiotensin II (Ang-II)-induced myocardial hypertrophy is...

    Authors: Rui Zhang, Yangyang Qu, Zhenjun Ji, Chunshu Hao, Yamin Su, Yuyu Yao, Wenjie Zuo, Xi Chen, Mingming Yang and Genshan Ma
    Citation: Cellular & Molecular Biology Letters 2022 27:55
  4. Organoids, which are organs grown in a dish from stem or progenitor cells, model the structure and function of organs and can be used to define molecular events during organ formation, model human disease, ass...

    Authors: Kate Tubbesing, Nicholas Moskwa, Ting Chean Khoo, Deirdre A. Nelson, Anna Sharikova, Yunlong Feng, Melinda Larsen and Alexander Khmaladze
    Citation: Cellular & Molecular Biology Letters 2022 27:53
  5. Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is the most important factor giving rise to this malignancy. The most not...

    Authors: Mohsen Karami Fath, Ali Azargoonjahromi, Arash Kiani, Fateme Jalalifar, Parisa Osati, Mahsa Akbari Oryani, Fateh Shakeri, Farhad Nasirzadeh, Behman Khalesi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Maysam Mard-Soltani and Zahra Payandeh
    Citation: Cellular & Molecular Biology Letters 2022 27:52
  6. Diabetic nephropathy (DN) is prevalent in patients with diabetes. N6-methyladenosine (m6A) methylation has been found to cause modification of nucleotide-binding oligomerization domain, leucine-rich repeat, and p...

    Authors: Jianzi Lan, Bowen Xu, Xin Shi, Qi Pan and Qing Tao
    Citation: Cellular & Molecular Biology Letters 2022 27:51
  7. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), a major international public health concern. Because of very similar amino acid sequences of th...

    Authors: Mohammadreza Saberiyan, Elham Karimi, Zahra Khademi, Parvaneh Movahhed, Amir Safi and Ameneh Mehri-Ghahfarrokhi
    Citation: Cellular & Molecular Biology Letters 2022 27:50
  8. The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, includ...

    Authors: Mostafa Vaghari-Tabari, Parisa Hassanpour, Fatemeh Sadeghsoltani, Faezeh Malakoti, Forough Alemi, Durdi Qujeq, Zatollah Asemi and Bahman Yousefi
    Citation: Cellular & Molecular Biology Letters 2022 27:49
  9. Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is urgent to find novel therapy strategies to overcome this feature. Metformin has been confirmed to suppress invasion...

    Authors: Dong Suwei, Xiao Yanbin, Wang Jianqiang, Ma Xiang, Peng Zhuohui, Kang Jianping, Wang Yunqing and Li Zhen
    Citation: Cellular & Molecular Biology Letters 2022 27:48
  10. Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of noncoding RNAs,...

    Authors: Jian-Zhi Zhao, Qi-Yao Li, Jia-Jie Lin, Li-Yun Yang, Mei-Yang Du, Yu Wang, Ke-Xin Liu, Ze-An Jiang, Huan-Huan Li, Si-Fan Wang, Bo Sun, Shi-Qing Mu, Bin Li, Kun Liu, Miao Gong and Shao-Guang Sun
    Citation: Cellular & Molecular Biology Letters 2022 27:47
  11. The submandibular gland (SMG) and the sublingual gland (SLG) are two of the three major salivary glands in mammals. In mice, they are adjacent to each other and open into the oral cavity, producing saliva to l...

    Authors: Wenping Luo, Panpan Liang, Tianyu Zhao, Qianyu Cheng, Huikai Liu, Liwen He, Linghuan Zhang, Bo Huang, Yuxin Zhang, Tongchuan He and Deqin Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:46
  12. Cancer-associated fibroblasts (CAFs) have been shown to support tumor development in a variety of cancers. Different markers were applied to classify CAFs in order to elucidate their impact on tumor progressio...

    Authors: Anna Muchlińska, Anna Nagel, Marta Popęda, Jolanta Szade, Magdalena Niemira, Jacek Zieliński, Jarosław Skokowski, Natalia Bednarz-Knoll and Anna J. Żaczek
    Citation: Cellular & Molecular Biology Letters 2022 27:45
  13. Obstructive sleep apnea is associated with increased lung cancer incidence and mortality. Cancer stem cells (CSCs) are characterized by their self-renewing ability, which contributes to metastasis, recurrence,...

    Authors: Shengyu Hao, Fan Li, Pan Jiang and Jian Gao
    Citation: Cellular & Molecular Biology Letters 2022 27:44
  14. The pivotal role of long noncoding RNAs (lncRNAs) in cancer immune responses has been well established. This study was conducted with the aim of exploring the molecular mechanism of lncRNA small nucleolar RNA ...

    Authors: Yusheng Huang, Lei Xia, Xiangwu Tan, Jingyi Zhang, Weiwei Zeng, Benxu Tan, Xian Yu, Wei Fang and Zhenzhou Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:43
  15. The appearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its spread all over the world is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has recently resulted in...

    Authors: Lucyna Matusewicz, Marlena Golec, Aleksander Czogalla, Kazimierz Kuliczkowski, Adam Konka, Joanna Zembala-John and Aleksander F. Sikorski
    Citation: Cellular & Molecular Biology Letters 2022 27:42
  16. The molecular mechanisms driving hepatocellular carcinoma (HCC) remain largely unclear. As one of the major epitranscriptomic modifications, N6-methyladenosine (m6A) plays key roles in HCC. The aim of this study ...

    Authors: Yun-zhang Dai, Yong-da Liu, Jie Li, Mei-ting Chen, Mei Huang, Fang Wang, Qing-song Yang, Ji-hang Yuan and Shu-han Sun
    Citation: Cellular & Molecular Biology Letters 2022 27:41
  17. In patients with acute aortic dissection (AAD), increased vascular smooth muscle cell (VSMC) apoptosis has been found. Human cytomegalovirus (HCMV)-miR-US33-5p was significantly increased in the plasma of pati...

    Authors: Jian Dong, Shuangshuang Li, Zilin Lu, Pengcheng Du, Guangqin Liu, Mintao Li, Chao Ma, Jian Zhou and Junmin Bao
    Citation: Cellular & Molecular Biology Letters 2022 27:40
  18. Esophageal squamous cell carcinoma (ESCC) is correlated with worse clinical prognosis and lacks available targeted therapy. Thus, identification of reliable biomarkers is required for the diagnosis and treatme...

    Authors: Jinfeng Zhang, Xiaodong Ling, Chengyuan Fang and Jianqun Ma
    Citation: Cellular & Molecular Biology Letters 2022 27:39
  19. Designing and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 (COVID-19) pandemic, many large pharmaceutical and biotec...

    Authors: Armina Alagheband Bahrami, Ali Azargoonjahromi, Samin Sadraei, Aryan Aarabi, Zahra Payandeh and Masoumeh Rajabibazl
    Citation: Cellular & Molecular Biology Letters 2022 27:38
  20. In nature, lectins are widely dispersed proteins that selectively recognize and bind to carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral diseases have been treated w...

    Authors: Mohsen Nabi-Afjadi, Morteza Heydari, Hamidreza Zalpoor, Ibrahim Arman, Arezoo Sadoughi, Parisa Sahami and Safiyeh Aghazadeh
    Citation: Cellular & Molecular Biology Letters 2022 27:37
  21. RING finger protein 7 (RNF7) is a highly conserved protein that functions as an E3 ubiquitin ligase. RNF7 overexpression is indicated in multiple human cancers, but its role in renal cell carcinoma (RCC) and t...

    Authors: Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang and Qing Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:36
  22. The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/C...

    Authors: Sadegh Shojaei Baghini, Zhanna R. Gardanova, Saeme Azizi Hassan Abadi, Burhan Abdullah Zaman, Ahmet İlhan, Navid Shomali, Ali Adili, Roozbeh Moghaddar and Amirhossein Fakhre Yaseri
    Citation: Cellular & Molecular Biology Letters 2022 27:35
  23. Vital organ injury is one of the leading causes of global deaths. Accumulating studies have demonstrated that dexmedetomidine (DEX) has an outstanding protective effect on multiple organs for its antiinflammat...

    Authors: Shankun Zhao, Weizhou Wu, Xuezheng Lin, Maolei Shen, Zhenyu Yang, Sicong Yu and Yu Luo
    Citation: Cellular & Molecular Biology Letters 2022 27:34
  24. Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to d...

    Authors: Mohsen Karami Fath, Kimiya Babakhaniyan, Maryam Zokaei, Azadeh Yaghoubian, Sadaf Akbari, Mahdieh Khorsandi, Asma Soofi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Fateme Jalalifar, Ali Azargoonjahromi, Zahra Payandeh and Armina Alagheband Bahrami
    Citation: Cellular & Molecular Biology Letters 2022 27:33
  25. Autophagy plays an essential role in maintaining cellular homeostasis and in the response to cellular stress. Autophagy is also involved in cell cycle progression, yet the relationship between these processes ...

    Authors: Alena Gschwind, Christian Marx, Marie D. Just, Paula Severin, Hannah Behring, Lisa Marx-Blümel, Sabine Becker, Linda Rothenburger, Martin Förster, James F. Beck and Jürgen Sonnemann
    Citation: Cellular & Molecular Biology Letters 2022 27:32
  26. Diabetic nephropathy (DN) is regarded as the main vascular complication of diabetes mellitus, directly affecting the outcome of diabetic patients. Inflammatory factors were reported to participate in the progr...

    Authors: Fei Wang, Wenting Hou, Xue Li, Lihong Lu, Ting Huang, Minmin Zhu and Changhong Miao
    Citation: Cellular & Molecular Biology Letters 2022 27:30
  27. Acute lung injury (ALI) has received considerable attention in the field of intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in citrus fruits, is a natural bioactive ...

    Authors: Jin Li, Shi-hua Deng, Jing Li, Li Li, Feng Zhang, Ye Zou, Dong-ming Wu and Ying Xu
    Citation: Cellular & Molecular Biology Letters 2022 27:29
  28. Parecoxib plays an important role in inhibition of human cancer. However, the effect of parecoxib on esophageal squamous cell carcinoma (ESCC) is still not well known. The purpose of this study was to investig...

    Authors: Han-Ming Huang, Xiao-Yu Huang, Shao-Ping Wu, Can-Keng Chen, Xin-Hua He and Yong-Fa Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:28
  29. After spinal cord injury (SCI), dysregulated or nonresolving inflammatory processes can severely disturb neuronal homeostasis and drive neurodegeneration. Although mesenchymal stromal cell (MSC)-based therapie...

    Authors: Tianyun Gao, Feifei Huang, Wenqing Wang, Yuanyuan Xie and Bin Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:27
  30. N6-methyladenosine (m6A) is the most common and abundant internal modification of RNA. Its critical functions in multiple physiological and pathological processes have been reported. However, the role of m6A in s...

    Authors: Wenqing Sun, Yan Li, Dongyu Ma, Yi Liu, Qi Xu, Demin Cheng, Guanru Li and Chunhui Ni
    Citation: Cellular & Molecular Biology Letters 2022 27:26
  31. Accumulating evidence indicates that miR-5195-3p exerts tumor-suppressive roles in several tumors. However, the clinical significance and biological function of miR-5195-3p in prostate cancer (PCa) have not been ...

    Authors: Xing Zeng, Zhiquan Hu, Yuanqing Shen, Xian Wei, Jiahua Gan and Zheng Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:25
  32. Transmembrane protein 43 (TMEM43), a member of the transmembrane protein subfamily, plays a critical role in the initiation and development of cancers. However, little is known concerning the biological functi...

    Authors: Junqiang Li, Yang Song, Chao Zhang, Ronglin Wang, Lei Hua, Yongdong Guo, Dongxue Gan, Liaoliao Zhu, Shanshan Li, Peixiang Ma, Cheng Yang, Hong Li, Jing Yang, Jingjie Shi, Xiaonan Liu and Haichuan Su
    Citation: Cellular & Molecular Biology Letters 2022 27:24
  33. ROR2 is a tyrosine-kinase receptor whose expression is dysregulated in many human diseases. In cancer, ROR2 stimulates proliferation, survival, migration, and metastasis, and is associated with more aggressive...

    Authors: María Victoria Castro, Gastón Alexis Barbero, Paula Máscolo, Rocío Ramos, María Josefina Quezada and Pablo Lopez-Bergami
    Citation: Cellular & Molecular Biology Letters 2022 27:23

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2022 27:54

  34. Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequac...

    Authors: Mina Homayoonfal, Zatollah Asemi and Bahman Yousefi
    Citation: Cellular & Molecular Biology Letters 2022 27:21
  35. EGFR targeting is currently the main treatment strategy for metastatic colorectal cancer (mCRC). Results of different clinical trials show that patients with wild-type KRAS and BRAF benefit from anti-EGFR mono...

    Authors: Donatella Romaniello, Valerio Gelfo, Federica Pagano, Enea Ferlizza, Michela Sgarzi, Martina Mazzeschi, Alessandra Morselli, Carmen Miano, Gabriele D’Uva and Mattia Lauriola
    Citation: Cellular & Molecular Biology Letters 2022 27:20
  36. Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promo...

    Authors: Yi-Fang Yang, Chuang-Ming Wang, I.-Hsin Hsiao, Yi-Liang Liu, Wen-Hao Lin, Chih-Li Lin, Hui-Chih Hung and Guang-Yaw Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:19
  37. Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial for tumor progression; however, its role in hepatocellular carcinoma (HCC) and the underlying mechanisms are not well characterized.

    Authors: Le Lu, Jingjing Huang, Jiantao Mo, Xuanbo Da, Qiaoxin Li, Meng Fan and Hongwei Lu
    Citation: Cellular & Molecular Biology Letters 2022 27:17
  38. Allergic contact dermatitis (ACD) is a common skin condition characterized by contact hypersensitivity to allergens, accompanied with skin inflammation and a mixed itch and pain sensation. The itch and pain dr...

    Authors: Boyu Liu, Ruixiang Chen, Jie Wang, Yuanyuan Li, Chengyu Yin, Yan Tai, Huimin Nie, Danyi Zeng, Junfan Fang, Junying Du, Yi Liang, Xiaomei Shao, Jianqiao Fang and Boyi Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:16
  39. MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In particular, miRNA let-7 functions as an ...

    Authors: Arash Letafati, Sajad Najafi, Mehran Mottahedi, Mohammad Karimzadeh, Ali Shahini, Setareh Garousi, Mohammad Abbasi-Kolli, Javid Sadri Nahand, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Neda Rahimian, Mohammad Taghizadieh and Hamed Mirzaei
    Citation: Cellular & Molecular Biology Letters 2022 27:14
  40. In recent years, morbidity and mortality of prostate cancer (PCa) have increased dramatically, while mechanistic understanding of its onset and progression remains unmet. LncRNA SNHG3 has been proved to stimul...

    Authors: Xiaotian Wang, Yongsheng Song, Yaxing Shi, Da Yang, Jiaxing Li and Bo Yin
    Citation: Cellular & Molecular Biology Letters 2022 27:13
  41. The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucle...

    Authors: Silvia Chichiarelli, Fabio Altieri, Giuliano Paglia, Elisabetta Rubini, Marco Minacori and Margherita Eufemi
    Citation: Cellular & Molecular Biology Letters 2022 27:12
  42. The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronaviru...

    Authors: Hamidreza Zalpoor, Abdullatif Akbari, Azam Samei, Razieh Forghaniesfidvajani, Monireh Kamali, Azadeh Afzalnia, Shirin Manshouri, Fatemeh Heidari, Majid Pornour, Majid Khoshmirsafa, Hossein Aazami and Farhad Seif
    Citation: Cellular & Molecular Biology Letters 2022 27:10
  43. Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survi...

    Authors: M. Kanmalar, Siti Fairus Abdul Sani, Nur Izzahtul Nabilla B. Kamri, Nur Akmarina B. M. Said, Amirah Hajirah B. A. Jamil, S. Kuppusamy, K. S. Mun and D. A. Bradley
    Citation: Cellular & Molecular Biology Letters 2022 27:9
  44. Glycosyltransferases play a crucial role in various cancers. β1, 3-N-acetylglucosaminyltransferase 2, a polylactosamine synthase, is an important member of the glycosyltransferase family. However, the biological ...

    Authors: Zhiguo Luo, Qing Hu, Yuanhui Tang, Yahui Leng, Tian Tian, Shuangyue Tian, Chengyang Huang, Ao Liu, Xinzhou Deng and Li Shen
    Citation: Cellular & Molecular Biology Letters 2022 27:8

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