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  1. Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. P21-activated kinase 4 (PAK4) and miR-9-5p have emerged as attractive therapeutic targets in several tumor types, but in CRC, the r...

    Authors: Meihua Wang, Qianqian Gao, Yufang Chen, Ziyan Li, Lingping Yue and Yun Cao

    Citation: Cellular & Molecular Biology Letters 2019 24:58

    Content type: Research Letter

    Published on:

  2. Glucose-regulated protein 78 (GRP78) is a member of the HSP70 protein family and a key endoplasmic reticulum chaperone. It has been revealed to play important roles both in the maturation, folding and transpor...

    Authors: Ying Liu, Xuemei Wang, Zhen Zhen, Yanbo Yu, Youwen Qiu and Wensheng Xiang

    Citation: Cellular & Molecular Biology Letters 2019 24:57

    Content type: Research Letter

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  4. Hypoxia, a major condition associated with the tumor microenvironment, stimulates the migration of cancer cells. SOX2 is a powerful transcription factor that shows higher expression in several cancers, however...

    Authors: Yueyuan Wang, Maria Bibi, Pengxiang Min, Wenjie Deng, Yujie Zhang and Jun Du

    Citation: Cellular & Molecular Biology Letters 2019 24:55

    Content type: Research

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  5. Ectodermal dysplasias are characterized by developmental abnormalities in ectodermal structures. Hypohidrotic ectodermal dysplasias (HED) are the most common subtype. They are most commonly inherited via X-lin...

    Authors: Marzieh Rahbaran, Maryam Hassani Doabsari, Simindokht Salavitabar, Neda Mokhberian, Ziba Morovvati and Saeid Morovvati

    Citation: Cellular & Molecular Biology Letters 2019 24:54

    Content type: Research Letter

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  6. Gastric cancer is a malignant tumor with the fifth incidence and third mortality worldwide. There were 951,000 new cases and about 723,000 patients died of it in 2012. Undoubtedly, gastric cancer has been affe...

    Authors: Fei Jiang and Xiaobing Shen

    Citation: Cellular & Molecular Biology Letters 2019 24:53

    Content type: Review

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  7. Hepatic stellate cell (HSC) activation is a central event during hepatic fibrosis. Aerobic glycolysis is one of its metabolic hallmarks. Blocking glycolysis is a novel therapeutic option for liver fibrosis. Th...

    Authors: Dujing Ban, Shangbo Hua, Wen Zhang, Chao Shen, Xuehua Miao and Wensheng Liu

    Citation: Cellular & Molecular Biology Letters 2019 24:52

    Content type: Research Letter

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  8. MicroRNAs (miRNAs or miRs) serve crucial roles in the progression of osteoporosis. This study investigated the role and specific molecular mechanism of miR-135-5p in regulating osteoblast differentiation and c...

    Authors: Nuo Yin, Longzhang Zhu, Liang Ding, Junjie Yuan, Li Du, Mingmang Pan, Feng Xue and Haijun Xiao

    Citation: Cellular & Molecular Biology Letters 2019 24:51

    Content type: Research

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  9. Long non-coding RNA Malat1 has been widely identified as an oncogene which shows a significant relationship with tumorigenesis in colorectal cancer (CRC). Nonetheless, whether Malat1 participates in the autoph...

    Authors: Yaoran Si, Zhaoguo Yang, Quanxing Ge, Lingbing Yu, Meiying Yao, Xinfang Sun, Zheng Ren and Chunsheng Ding

    Citation: Cellular & Molecular Biology Letters 2019 24:50

    Content type: Research

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  10. Synuclein-γ has been demonstrated to be highly expressed in various human cancers including cervical cancer, and has been shown to play a critical role in tumor aggressiveness. We aimed to investigate the role of...

    Authors: Chunnian Zhang, Liqin Gu, Xiafang Li and Jianzhong Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:49

    Content type: Research Letter

    Published on:

  11. In recent years, microRNA-211 (miR211) has been considered as a tumor suppressor in multiple malignancies. However, the function of miR211 in human osteosarcoma has not been explored intensively so far. In thi...

    Authors: Yihua Pei, Qin Yao, Yingchao Li, Xin Zhang and Bozhen Xie

    Citation: Cellular & Molecular Biology Letters 2019 24:48

    Content type: Research Letter

    Published on:

  12. Chemotherapy based on paclitaxel (PTX) is the standard treatment for a range of cancers, including triple-negative breast cancer (TNBC), but the increasing development of resistance has reduced/has negatively ...

    Authors: Mei Liu, Can Gong, Renyuan Xu, Yu Chen and Xiaodong Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:47

    Content type: Research

    Published on:

  14. The study aimed to investigate the effect of oxidative stress on Prestin expression, and explore the transcription factors (TFs) that are involved in regulating the expression of Prestin in House Ear Institute-Or...

    Authors: Xuan Luo, Yun Xia, Xu-Dong Li and Jun-Yi Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:45

    Content type: Research

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  15. Deer antler is the only mammalian organ that can be completely regenerated every year. Its periodic regeneration is regulated by multiple factors, including transforming growth factor β (TGF-β). This widely di...

    Authors: Mingxiao Liu, Xiangyu Han, Hongyun Liu, Danyang Chen, Yue Li and Wei Hu

    Citation: Cellular & Molecular Biology Letters 2019 24:44

    Content type: Research Letter

    Published on:

  16. Impairment of the blood–brain barrier (BBB) could result in secondary cerebral edema and life-threatening pancreatic encephalopathy in patients with severe acute pancreatitis (SAP). Mesenchymal stem cells (MSC...

    Authors: Ronggui Lin, Ming Li, Meiqin Luo, Tianhong Teng, Yu Pan and Heguang Huang

    Citation: Cellular & Molecular Biology Letters 2019 24:43

    Content type: Research

    Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2019 24:56

  17. Human bronchial epithelium (HBE)-Dp71 anti-sense(AS)cells with stably transfected Dp71 siRNA plasmids were prepared for further exploration of Dp71 biological traits in cells other than PC12. HBE-Dp71AS cells ...

    Authors: Sichuang Tan, Shuai Zhao, Xuefei Xiao, Lan Xiao, Jinliang Xie and Sipin Tan

    Citation: Cellular & Molecular Biology Letters 2019 24:42

    Content type: Research

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  19. Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in...

    Authors: Linyan Zhu and Liqun Chen

    Citation: Cellular & Molecular Biology Letters 2019 24:40

    Content type: Review Letter

    Published on:

  20. The aim of this study was to investigate the effect of human umbilical vein endothelial cells on epithelial-to-mesenchymal transition of the cervical cancer cell line SiHa by studying the Notch1/lysyl oxidase ...

    Authors: Jinghua Ou, Defeng Guan and Yongxiu Yang

    Citation: Cellular & Molecular Biology Letters 2019 24:39

    Content type: Research Letter

    Published on:

  21. Exploration of the genes with abnormal expression during the development of breast cancer is essential to provide a deeper understanding of the mechanisms involved. Transcriptome sequencing and bioinformatics ...

    Authors: Yulong Bao, Li Wang, Lin Shi, Fen Yun, Xia Liu, Yongxia Chen, Chen Chen, Yanni Ren and Yongfeng Jia

    Citation: Cellular & Molecular Biology Letters 2019 24:38

    Content type: Research

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  22. Accumulating evidence has shown that altered microRNA (miR) modulation is implicated in the pathologies of ischemic stroke. However, it is unclear whether and how hsa-miR-19a-3p mediates cerebral ischemic inju...

    Authors: Xiao-Li Ge, Jin-Li Wang, Xin Liu, Jia Zhang, Chang Liu and Li Guo

    Citation: Cellular & Molecular Biology Letters 2019 24:37

    Content type: Research

    Published on:

  23. Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation, induction of apoptosis, and inhibition of energy me...

    Authors: Zhihua Ren, Hongyi He, Zhicai Zuo, Zhiwen Xu, Zhanyong Wei and Junliang Deng

    Citation: Cellular & Molecular Biology Letters 2019 24:36

    Content type: Review

    Published on:

  24. Pulmonary edema is one of the pathological characteristics of acute respiratory distress syndrome (ARDS). The epithelial sodium channel (ENaC) is thought to be the rate-limiting factor for alveolar fluid clear...

    Authors: Jing He, Di Qi, Xu-mao Tang, Wang Deng, Xin-yu Deng, Yan Zhao and Dao-xin Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:35

    Content type: Short report

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  26. Induction of lysosomal function and autophagy is regarded as an adaptive mechanism in response to cellular stress. The transcription factor EB (TFEB) has been identified as a master regulator of lysosomal func...

    Authors: Hsuan-Yeh Pan, Abdulla H. Alamri and Mallika Valapala

    Citation: Cellular & Molecular Biology Letters 2019 24:33

    Content type: Short report

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  27. Peritoneal fibrosis remains a serious complication of long-term peritoneal dialysis (PD) leading to peritoneal membrane ultrafiltration failure. Epithelial–mesenchymal transition (EMT) of peritoneal mesothelia...

    Authors: Jun-Li Zhao, Mei-Zi Guo, Jun-Jun Zhu, Ting Zhang and Dan-Yan Min

    Citation: Cellular & Molecular Biology Letters 2019 24:32

    Content type: Research Letter

    Published on:

  29. Gemcitabine (2′,2′-difluoro-2′-deoxycytidine;dFdC) is a first-line chemotherapy drug for pancreatic cancer. Recently, a synergistic anti-tumor treatment of dFdC and hyperthermia has achieved good clinical resu...

    Authors: HB Jin, L Lu, L Xie, JF Yang, XF Zhang and SL Ma

    Citation: Cellular & Molecular Biology Letters 2019 24:30

    Content type: Short report

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  30. In its RING domain, tumor necrosis factor receptor-associated factor 6 (TRAF6) has ubiquitin E3 ligase activity that facilitates the formation of lysine 63-linked polyubiquitin chains. This activity is require...

    Authors: Hyun-Duk Jang, Hye Zin Hwang, Hyo-Soo Kim and Soo Young Lee

    Citation: Cellular & Molecular Biology Letters 2019 24:29

    Content type: Research Letter

    Published on:

  31. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor with a pivotal role in physiological and pathological responses to hypoxia. While HIF-1α is known to be involved in hypoxia-induced upregulation o...

    Authors: Yuree Byun, Young-Chul Choi, Yunhui Jeong, Gangtae Lee, Sena Yoon, Yongsu Jeong, Jaeseung Yoon and Kwanghee Baek

    Citation: Cellular & Molecular Biology Letters 2019 24:28

    Content type: Short report

    Published on:

  32. This study aimed to investigate the effects of miR-613 on the proliferation, invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs).

    Authors: Liang Liu, Yanhua Zuo, Yan Xu, Zongfang Zhang, Ying Li and Jie Pang

    Citation: Cellular & Molecular Biology Letters 2019 24:8

    Content type: Research

    Published on:

  34. Given the high mortality rate and unclear pathogenesis for liver cancer, investigation of its molecular mechanisms is essential. We focused on the long non-coding RNA (lncRNA) MIR4435-2HG, which was recently r...

    Authors: Qinglei Kong, Caiqian Liang, Yi Jin, Yuhang Pan, Dayue Tong, Qingcong Kong and Jing Zhou

    Citation: Cellular & Molecular Biology Letters 2019 24:26

    Content type: Research Letter

    Published on:

  35. Autologous cultivated oral mucosal epithelial transplantation (COMET) is an important treatment for limbal stem cell deficiency. However, peripheral corneal neovascularization after surgery hinders its applica...

    Authors: Chao-Ye Duan, Hua-Tao Xie, Xin-Yue Zhao, Wen-Han Xu and Ming-Chang Zhang

    Citation: Cellular & Molecular Biology Letters 2019 24:3

    Content type: Research

    Published on:

  36. Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress. Recent studies sho...

    Authors: Shujun Li, Zhongyi Sun, Tao Chen, Jingjing Pan, Yanqing Shen, Xiaoqing Chen, Xiaoyu Zhou, Rui Cheng and Yang Yang

    Citation: Cellular & Molecular Biology Letters 2019 24:25

    Content type: Research

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  39. Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity.

    Authors: Monique Meyenberg Cunha-de Padua, Guilhermina Rodrigues Noleto, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Frédéric Bost, Jacques Pouysségur and Nathalie M. Mazure

    Citation: Cellular & Molecular Biology Letters 2019 24:18

    Content type: Short report

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  41. The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant assoc...

    Authors: Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Mina Fathi-Kazerooni, Behrooz Johari and Zohreh Saltanatpour

    Citation: Cellular & Molecular Biology Letters 2019 24:12

    Content type: Short report

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  42. Overcoming chemorestistance to 5-fluorouracil (5-FU) could offer a new treatment option for highly malignant colon cancer. In our study, differential microRNA expression profiling revealed that miR-214 is down...

    Authors: Yong Yang, Yan Bao, Guo-Kai Yang, Jia Wan, Ling-Juan Du and Zhen-Huan Ma

    Citation: Cellular & Molecular Biology Letters 2019 24:22

    Content type: Research

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  43. Mechanical loading is an essential factor for bone formation. A previous study indicated that mechanical tensile strain of 2500 microstrain (με) at 0.5 Hz for 8 h promoted osteogenesis and corresponding mechan...

    Authors: Qiangcheng Zeng, Yang Wang, Jie Gao, Zhixiong Yan, Zhenghua Li, Xianqiong Zou, Yanan Li, Jiahui Wang and Yong Guo

    Citation: Cellular & Molecular Biology Letters 2019 24:11

    Content type: Research Letters

    Published on:

  44. Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction...

    Authors: Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang and Quanwei Zhang

    Citation: Cellular & Molecular Biology Letters 2019 24:21

    Content type: Research

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  45. This study was designed to investigate the potential role of microRNA-29c (miR-29c) in biliary atresia-related fibrosis. The expression of miR-29c was determined in 15 pairs of peripheral blood samples from in...

    Authors: Jian-yao Wang, Hao Cheng, Hong-yan Zhang, Yong-qin Ye, Qi Feng, Zi-min Chen, Yue-lan Zheng, Zhou-guang Wu, Bin Wang and Jun Yao

    Citation: Cellular & Molecular Biology Letters 2019 24:10

    Content type: Short report

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  47. Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms of miR...

    Authors: Zhen-Hua Gong, Feng Zhou, Chao Shi, Tie Xiang, Chang-Kai Zhou, Qian-Qian Wang, Ya-Su Jiang and Sheng-Feng Gao

    Citation: Cellular & Molecular Biology Letters 2019 24:9

    Content type: Research

    Published on:

  48. Cyclin-dependent kinase-like 1 (CDKL1) is a member of the cell division control protein 2-related serine–threonine protein kinase family. It is known to occur in various malignant tumors, but its role in neuro...

    Authors: Weiyi Li, Jing Cao, Jian Liu, Wenli Chu, Congqing Zhang, Shuiling Chen and Zefeng Kang

    Citation: Cellular & Molecular Biology Letters 2019 24:19

    Content type: Research Letters

    Published on:

  50. We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO).

    Authors: Qing Yang, Dan Dan Huang, Da Guang Li, Bo Chen, Ling Min Zhang, Cui Ling Yuan and Hong Hong Huang

    Citation: Cellular & Molecular Biology Letters 2019 24:17

    Content type: Research

    Published on:

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