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  1. Given the high mortality rate and unclear pathogenesis for liver cancer, investigation of its molecular mechanisms is essential. We focused on the long non-coding RNA (lncRNA) MIR4435-2HG, which was recently r...

    Authors: Qinglei Kong, Caiqian Liang, Yi Jin, Yuhang Pan, Dayue Tong, Qingcong Kong and Jing Zhou
    Citation: Cellular & Molecular Biology Letters 2019 24:26
  2. Autologous cultivated oral mucosal epithelial transplantation (COMET) is an important treatment for limbal stem cell deficiency. However, peripheral corneal neovascularization after surgery hinders its applica...

    Authors: Chao-Ye Duan, Hua-Tao Xie, Xin-Yue Zhao, Wen-Han Xu and Ming-Chang Zhang
    Citation: Cellular & Molecular Biology Letters 2019 24:3
  3. Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress. Recent studies sho...

    Authors: Shujun Li, Zhongyi Sun, Tao Chen, Jingjing Pan, Yanqing Shen, Xiaoqing Chen, Xiaoyu Zhou, Rui Cheng and Yang Yang
    Citation: Cellular & Molecular Biology Letters 2019 24:25
  4. Polysaccharides from various sources have been used in traditional medicine for centuries. The beneficial pharmacological effects of plant-derived polysaccharides include anti-tumor activity.

    Authors: Monique Meyenberg Cunha-de Padua, Guilhermina Rodrigues Noleto, Carmen Lucia de Oliveira Petkowicz, Silvia Maria Suter Correia Cadena, Frédéric Bost, Jacques Pouysségur and Nathalie M. Mazure
    Citation: Cellular & Molecular Biology Letters 2019 24:18
  5. The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant assoc...

    Authors: Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Mina Fathi-Kazerooni, Behrooz Johari and Zohreh Saltanatpour
    Citation: Cellular & Molecular Biology Letters 2019 24:12
  6. Overcoming chemorestistance to 5-fluorouracil (5-FU) could offer a new treatment option for highly malignant colon cancer. In our study, differential microRNA expression profiling revealed that miR-214 is down...

    Authors: Yong Yang, Yan Bao, Guo-Kai Yang, Jia Wan, Ling-Juan Du and Zhen-Huan Ma
    Citation: Cellular & Molecular Biology Letters 2019 24:22
  7. Mechanical loading is an essential factor for bone formation. A previous study indicated that mechanical tensile strain of 2500 microstrain (με) at 0.5 Hz for 8 h promoted osteogenesis and corresponding mechan...

    Authors: Qiangcheng Zeng, Yang Wang, Jie Gao, Zhixiong Yan, Zhenghua Li, Xianqiong Zou, Yanan Li, Jiahui Wang and Yong Guo
    Citation: Cellular & Molecular Biology Letters 2019 24:11
  8. Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction...

    Authors: Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang and Quanwei Zhang
    Citation: Cellular & Molecular Biology Letters 2019 24:21
  9. This study was designed to investigate the potential role of microRNA-29c (miR-29c) in biliary atresia-related fibrosis. The expression of miR-29c was determined in 15 pairs of peripheral blood samples from in...

    Authors: Jian-yao Wang, Hao Cheng, Hong-yan Zhang, Yong-qin Ye, Qi Feng, Zi-min Chen, Yue-lan Zheng, Zhou-guang Wu, Bin Wang and Jun Yao
    Citation: Cellular & Molecular Biology Letters 2019 24:10
  10. Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms of miR...

    Authors: Zhen-Hua Gong, Feng Zhou, Chao Shi, Tie Xiang, Chang-Kai Zhou, Qian-Qian Wang, Ya-Su Jiang and Sheng-Feng Gao
    Citation: Cellular & Molecular Biology Letters 2019 24:9
  11. Cyclin-dependent kinase-like 1 (CDKL1) is a member of the cell division control protein 2-related serine–threonine protein kinase family. It is known to occur in various malignant tumors, but its role in neuro...

    Authors: Weiyi Li, Jing Cao, Jian Liu, Wenli Chu, Congqing Zhang, Shuiling Chen and Zefeng Kang
    Citation: Cellular & Molecular Biology Letters 2019 24:19
  12. We investigated the protective effect of tetramethylpyrazine (TMP) on injury related to acute myocardial ischemia (AMI) induced by isoproterenol (ISO).

    Authors: Qing Yang, Dan Dan Huang, Da Guang Li, Bo Chen, Ling Min Zhang, Cui Ling Yuan and Hong Hong Huang
    Citation: Cellular & Molecular Biology Letters 2019 24:17
  13. Indian hedgehog (IHH) and Sonic hedgehog (SHH) are important regulators of chondrogenesis. However, activation of IHH and SHH also promotes chondrocyte hypertrophy and ossification during chondrogenesis. The a...

    Authors: Liyang Chen, Gejun Liu, Wenjun Li and Xing Wu
    Citation: Cellular & Molecular Biology Letters 2019 24:16
  14. Tetrahydroxy stilbene glucoside (TSG) has been reported to exert a cytoprotective effect against various toxicants. However, the function and mechanism of TSG in palmitic acid (PA)-induced inflammation and apo...

    Authors: Yong ZOU and Min KONG
    Citation: Cellular & Molecular Biology Letters 2019 24:5
  15. The proliferation and adipogenic differentiation of adipose stromal cells (ASCs) are complex processes comprising major phenotypical alterations driven by up- and downregulation of hundreds of genes. Quantitat...

    Authors: Claudia Krautgasser, Markus Mandl, Florian M. Hatzmann, Petra Waldegger, Monika Mattesich and Werner Zwerschke
    Citation: Cellular & Molecular Biology Letters 2019 24:14
  16. Hepatitis B virus (HBV) infection is acknowledged as the main cause of hepatocellular carcinoma (HCC). Moreover, previous studies have revealed that microRNAs (miRNAs) widely participate in regulation of vario...

    Authors: Zhitao Zhang, Yanzhen Han, Guangxin Sun, Xiaohong Liu, Xiaoyan Jia and Xiangjun Yu
    Citation: Cellular & Molecular Biology Letters 2019 24:13
  17. The tumor susceptibility gene 101 (TSG101) is closely associated with various tumor types, but its role in the pathogenesis of renal cell carcinoma (RCC) is still unknown. This study used RNA interference to s...

    Authors: Chen Xu and Junhua Zheng
    Citation: Cellular & Molecular Biology Letters 2019 24:7
  18. To investigate the anti-tumor effects and the mechanism of the compound 13-chlorine-3, 15-dioxy-gibberellic acid methyl ester (GA-13315) in lung adenocarcinoma in vitro and in vivo.

    Authors: Lin Xie, Yajuan Chen, Jingbo Chen, Hongbin Zhang, Yedan Liao, Yonghong Zhou, Ling Zhou and Chen Qing
    Citation: Cellular & Molecular Biology Letters 2019 24:6
  19. Extracellular vesicles are small vesicles that contain cytoplasmic and membrane components from their paternal cells. They enter target cells through uptake to transfer their biological cargo. In this study, w...

    Authors: Martyna Durak-Kozica, Zbigniew Baster, Karol Kubat and Ewa Stępień
    Citation: Cellular & Molecular Biology Letters 2018 23:57
  20. Adjuvant chemotherapy has become the frequently adopted standard therapeutic approach for non-small cell lung cancer (NSCLC). However, the development of multidrug resistance (MDR) is a major obstacle contribu...

    Authors: Huaping Huang, Tangying Li, Mingjing Chen, Feng Liu, Haifeng Wu, Jie Wang, Jialiang Chen and Xi Li
    Citation: Cellular & Molecular Biology Letters 2018 23:54
  21. Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying...

    Authors: Xing’an Zhang, Lanfang Zhang, Xiaoyao Tan, Ying Lin, Xinsheng Han, Huadong Wang, Huawei Ming, Qiujiang Li, Kang Liu and Gang Feng
    Citation: Cellular & Molecular Biology Letters 2018 23:53
  22. Pulmonary inflammation and endothelial barrier permeability increase in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) induced by pro-inflammatory cytokines and matrix metalloproteinase...

    Authors: Yafeng Liang, Nengli Yang, Guoquan Pan, Bingxin Jin, Shufen Wang and Wei Ji
    Citation: Cellular & Molecular Biology Letters 2018 23:52
  23. Breast cancer is the most prevalent cancer among women, and AXL and MET are the key genes in the PI3K/AKT/mTOR pathway as critical elements in proliferation and invasion of cancer cells. MicroRNAs (miRNAs) are sm...

    Authors: Shadan Hajalirezay Yazdi, Mahdi Paryan and Samira Mohammadi-Yeganeh
    Citation: Cellular & Molecular Biology Letters 2018 23:51
  24. Microcystins are waterborne environmental toxins that induce oxidative stress and cause injuries in the heart. On the other hand, many physiological processes, including antioxidant defense, are under precise ...

    Authors: Yonghua Xu, Xiangmin Wang, Surong Jiang, Chen Men, Di Xu, Yan Guo and Jun Wu
    Citation: Cellular & Molecular Biology Letters 2018 23:50
  25. To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown...

    Authors: Toru Miyanaga, Yoshimichi Ueda, Aiko Miyanaga, Mikio Yagishita and Naoko Hama
    Citation: Cellular & Molecular Biology Letters 2018 23:49
  26. Tissue ischemia can arise in response to numerous physiologic and pathologic conditions. The cellular response to decreased perfusion, most notably a decrease in glucose and oxygen, is important for cellular s...

    Authors: Grey W Fortenbery, Brinda Sarathy, Kristen R Carraway and Kyle D Mansfield
    Citation: Cellular & Molecular Biology Letters 2018 23:48
  27. Evidence has shown that endogenous H2S plays an important role in the physiological and pathophysiological processes of many organs. The study aimed to explore whether exogenous H2S has a potential therapeutic ef...

    Authors: Zhong-Shi Xu, Feng Dai, Ji Chen, Meng Lv, Ji-Wu Cheng, Xiao-Ming Zhang and Bo-Wen Lin
    Citation: Cellular & Molecular Biology Letters 2018 23:47
  28. Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. The 5-year survival rate remains low despite considerable research into treatme...

    Authors: Maoyun Fei, Jianming Guan, Tao Xue, Lianjin Qin, Chengwu Tang, Ge Cui, Yao Wang, Hui Gong and Wenming Feng
    Citation: Cellular & Molecular Biology Letters 2018 23:46
  29. Recent developments in high-throughput genotyping technologies have revealed the existence of several new classes of RNA that do not encode proteins but serve other cellular roles. To date, these non-coding RN...

    Authors: Rafal Bartoszewski and Aleksander F. Sikorski
    Citation: Cellular & Molecular Biology Letters 2018 23:45
  30. Tumor microenvironment, in particular the stroma, plays an important role in breast cancer cell invasion and metastasis. Investigation of the molecular characteristics of breast cancer stroma may reveal target...

    Authors: Yanxia Wang, Hui Xu, Baoan Zhu, Zhenling Qiu and Zaijun Lin
    Citation: Cellular & Molecular Biology Letters 2018 23:44
  31. Lnc-DC is a specific group of long non-coding (Lnc) RNAs in dendritic cells (DCs). Its function has been previously studied, and includes roles in dendritic cell differentiation and the progression of some dis...

    Authors: Lifan Zhuang, Jianhua Tian, Xinzhi Zhang, Hong Wang and Chenghui Huang
    Citation: Cellular & Molecular Biology Letters 2018 23:43
  32. Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer, with a poor prognosis. Deregulation of WNT and NOTCH signaling pathways is important in ESCC progression, wh...

    Authors: Mohammad Reza Abbaszadegan, Anali Riahi, Mohammad Mahdi Forghanifard and Meysam Moghbeli
    Citation: Cellular & Molecular Biology Letters 2018 23:42
  33. MicroRNAs play important roles in regulation of the cardiovascular system. The purpose of this study was to investigate microRNA-320 (miR-320) expression in myocardial ischemia-reperfusion (I/R) injury and the...

    Authors: Zhi-Qiang Tian, Hong Jiang and Zhi-Bing Lu
    Citation: Cellular & Molecular Biology Letters 2018 23:41
  34. Imbalances in circulating T lymphocytes play critical roles in the pathogenesis of hypertension-mediated inflammation. Connexins (Cxs) in immune cells are involved in the maintenance of homeostasis of T lympho...

    Authors: Xin Ni, Xin-zhi Li, Zhi-ru Fan, Ai Wang, Hai-chao Zhang, Liang Zhang, Li LI, Jun-qiang Si and Ke-tao Ma
    Citation: Cellular & Molecular Biology Letters 2018 23:40
  35. The transcription factor Oct4 plays a pivotal role in the pre-implantation development of the mouse embryo. DNA methyltransferase 1 (Dnmt1) maintains the changes in DNA methylation during mammalian early embry...

    Authors: Fengrui Wu, Qingqing Wu, Dengkun Li, Yuan Zhang, Rong Wang, Yong Liu and Wenyong Li
    Citation: Cellular & Molecular Biology Letters 2018 23:39
  36. Inflammation is an important pathogenic component of endotoxemia-induced acute kidney injury (AKI), finally resulting in renal failure. Diacerein is an interleukin-1β (IL-1β) inhibitor used for osteoarthritis ...

    Authors: Guangzhe Yu, Qian Liu, Xuening Dong, Kaihong Tang, Bohui Li, Chunmei Liu, Wenzheng Zhang, Yiduo Wang and Yingyu Jin
    Citation: Cellular & Molecular Biology Letters 2018 23:38
  37. Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex tha...

    Authors: Wei Wu, Li Nie, Li Zhang and Yan Li
    Citation: Cellular & Molecular Biology Letters 2018 23:37
  38. Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may the...

    Authors: Ying Huang, Wuping Yang, Huihong Zeng, Chuan Hu, Yaqiong Zhang, Nanhua Ding, Guangqin Fan, Lijian Shao and Bohai Kuang
    Citation: Cellular & Molecular Biology Letters 2018 23:34

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