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  1. Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearl...

    Authors: Mokgadi Violet Gwangwa, Anna Margaretha Joubert and Michelle Helen Visagie
    Citation: Cellular & Molecular Biology Letters 2018 23:20
  2. Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored...

    Authors: Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang and Ming Yang
    Citation: Cellular & Molecular Biology Letters 2018 23:19
  3. Lycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP...

    Authors: Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li and Huilan Zhu
    Citation: Cellular & Molecular Biology Letters 2018 23:18
  4. Epstein–Barr virus (EBV) infection is causatively associated with a variety of human cancers, including gastric cancer (GC), which has one of the highest mortality rates of all human cancers. Long non-coding R...

    Authors: Jing Liu, Chunxia Yang, Yufang Gu, Chong Li, Huamei Zhang, Wenfang Zhang, Xueqing Wang, Nan Wu and Chunyan Zheng
    Citation: Cellular & Molecular Biology Letters 2018 23:17
  5. The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal e...

    Authors: Ruijie Gong, Xiaofei Lv and Fengqiong Liu
    Citation: Cellular & Molecular Biology Letters 2018 23:16
  6. The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the i...

    Authors: Gabriela Sánchez, Omar Estrada, Giovana Acha, Alfonso Cardozo, Franshelle Peña, Marie Christine Ruiz, Fabián Michelangeli and Claudia Alvarado-Castillo
    Citation: Cellular & Molecular Biology Letters 2018 23:15
  7. The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, w...

    Authors: Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang and Heng Wu
    Citation: Cellular & Molecular Biology Letters 2018 23:14
  8. Arsenic trioxide (As2O3) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2O3 has an antitumo...

    Authors: Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai and Kongbin Yang
    Citation: Cellular & Molecular Biology Letters 2018 23:13
  9. Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is invo...

    Authors: Michaela Galoczova, Philip Coates and Borivoj Vojtesek
    Citation: Cellular & Molecular Biology Letters 2018 23:12
  10. Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate i...

    Authors: Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh and Majd Aljamali
    Citation: Cellular & Molecular Biology Letters 2018 23:11
  11. The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against num...

    Authors: Laura Susan Boyd, Devrim Gozuacik and Anna Margaretha Joubert
    Citation: Cellular & Molecular Biology Letters 2018 23:10
  12. Previous studies indicated that cadmium (Cd) increases PI3-kinase/Akt phosphorylation, resulting in an alteration in GSK-3β activity. However, the mechanism of Cd-induced endoplasmic reticulum (ER) stress in n...

    Authors: Seungwoo Kim, Hyosoon Cheon, Sam-Moon Kim and Young-Youl Kim
    Citation: Cellular & Molecular Biology Letters 2018 23:9
  13. Platelet-derived growth factor-C (PDGF-C) has been shown to be involved in several biological processes, such as embryonic development, wound healing and angiogenesis, as well as in diseases including tumor fo...

    Authors: Tomoaki Kinjo, Chuanhai Sun, Tomomi Ikeda, Takako Ikegami, Yuhki Tada, Tadayuki Akagi, Takashi Yokota and Hiroshi Koide
    Citation: Cellular & Molecular Biology Letters 2018 23:8
  14. Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, i...

    Authors: Hao Yang, Di Wu, Hua Li, Nan Chen and Yongjun Shang
    Citation: Cellular & Molecular Biology Letters 2018 23:7
  15. Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene...

    Authors: Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li and Xiaohui Zhang
    Citation: Cellular & Molecular Biology Letters 2018 23:6
  16. Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteo...

    Authors: Nazli F. Eskici, Sevim Erdem-Ozdamar and Didem Dayangac-Erden
    Citation: Cellular & Molecular Biology Letters 2018 23:5
  17. Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. However, the effects of CGRP ...

    Authors: Shaohua Wang, Hongxing Dang, Feng Xu, Jian Deng and Xuemei Zheng
    Citation: Cellular & Molecular Biology Letters 2018 23:4
  18. Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to...

    Authors: Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Shoukath M. Ali, Moghis U. Ahmad and Imran Ahmad
    Citation: Cellular & Molecular Biology Letters 2018 23:3
  19. Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects....

    Authors: Ying Chen, Lei Zhang, Wen-xin Liu and Ke Wang
    Citation: Cellular & Molecular Biology Letters 2018 23:2
  20. Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apop...

    Authors: Yanan Li, Yu Yan, Fang Liu, Ming Wang, Fumin Feng and Yonghong Xiao
    Citation: Cellular & Molecular Biology Letters 2018 23:1
  21. The transcription factor TWIST1 plays an important role in the epithelial–mesenchymal transition (EMT) process and in the migration, invasion and metastasis of cancer cells. OCT4, which is a homeobox transcrip...

    Authors: Mohammad Hossein Izadpanah, Mohammad Reza Abbaszadegan, Yasaman Fahim and Mohammad Mahdi Forghanifard
    Citation: Cellular & Molecular Biology Letters 2017 22:33
  22. Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy. Semaphorin 3F (SEMA3F) is highly conserved but present at a lower level in various cancers than in healthy tissues. While it h...

    Authors: Yi Liu, Ronghua Li, Kai Yin, Gang Ren and Yongdong Zhang
    Citation: Cellular & Molecular Biology Letters 2017 22:32
  23. The natural dihydroflavonol (+) taxifolin was investigated for its protective effect on Fenton reagent-treated bone marrow-derived mesenchymal stem cells (bmMSCs). Various antioxidant assays were used to deter...

    Authors: Xican Li, Hong Xie, Qian Jiang, Gang Wei, Lishan Lin, Changying Li, Xingmei Ou, Lichan Yang, Yulu Xie, Zhen Fu, Yamei Liu and Dongfeng Chen
    Citation: Cellular & Molecular Biology Letters 2017 22:31
  24. Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are invo...

    Authors: Jian Ge, Qianxue Chen, Baohui Liu, Long Wang, Shenqi Zhang and Baowei Ji
    Citation: Cellular & Molecular Biology Letters 2017 22:30
  25. Several recent studies have demonstrated the great potential of bone marrow cells in regenerative medicine, not only for their ability to differentiate to match a damaged cell type, but also because they synth...

    Authors: Yolanda Menéndez-Menéndez, Jesús Otero-Hernández, Jose Antonio Vega, Marcos Pérez-Basterrechea, Silvia Pérez-López, María Álvarez-Viejo and Amaia Ferrero-Gutiérrez
    Citation: Cellular & Molecular Biology Letters 2017 22:29
  26. The development and integration of bio- and chemocatalytic processes to convert renewable or biomass feedstocks into polymers is a vibrant field of research with enormous potential for environmental protection...

    Authors: Aleksandra Marszałek-Harych, Dawid Jędrzkiewicz and Jolanta Ejfler
    Citation: Cellular & Molecular Biology Letters 2017 22:28
  27. Prolyl-hydroxyproline (Pro-Hyp) is one of the major constituents of collagen-derived dipeptides. We previously reported that Pro-Hyp promotes the differentiation of osteoblasts by increasing Runx2, osterix and...

    Authors: Yoshifumi Kimira, Haruka Odaira, Kaho Nomura, Yuri Taniuchi, Naoki Inoue, Sachie Nakatani, Jun Shimizu, Masahiro Wada and Hiroshi Mano
    Citation: Cellular & Molecular Biology Letters 2017 22:27
  28. Many studies have investigated the characteristics and biological activities of type III interferon (IFN), finding that it has similar features to type I IFN but also unique actions because it is recognized by...

    Authors: Wu-mei Yuan, Wan-ju Zhang, Fen-lian Ma, Jin-song Li, Qian Zhang and Li-shu Zheng
    Citation: Cellular & Molecular Biology Letters 2017 22:26
  29. The rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the ...

    Authors: Arati Suvatha, Sibin Madathan Kandi, Dhananjaya Ishwara Bhat, Narasinga Rao, Vikas Vazhayil and Chetan Ghati Kasturirangan
    Citation: Cellular & Molecular Biology Letters 2017 22:25
  30. Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The study aimed to explore the potential role of heat shock protein 27 (HSP27) in the pathogenesis of TAD using an in vitro model of ...

    Authors: Sili Zou, Mingfang Liao, Junlin Yang, Tong Huang, Mark Green, Jianjin Wu and Lefeng Qu
    Citation: Cellular & Molecular Biology Letters 2017 22:24
  31. Hypoxic conditions induce the expression of hypoxia-inducible factors (HIFs) that allow cells to adapt to the changing conditions and alter the expression of a number of genes including the cystic fibrosis tra...

    Authors: Sylwia Bartoszewska, Wojciech Kamysz, Bogdan Jakiela, Marek Sanak, Jarosław Króliczewski, Zsuzsa Bebok, Rafal Bartoszewski and James F. Collawn
    Citation: Cellular & Molecular Biology Letters 2017 22:23
  32. TGF-β1 plays an important role in the epithelial–mesenchymal transition (EMT) of epithelial cancers, including non-small cell lung cancer (NSCLC). While the full underlying mechanism remains unclear, miR-9 is ...

    Authors: Hui Wang, Qian Wu, Ying Zhang, Hua-Nan Zhang, Yong-Bin Wang and Wei Wang
    Citation: Cellular & Molecular Biology Letters 2017 22:22
  33. Our previous study found that single-pass membrane protein with coiled-coil domains 1 (C3orf43; XM_006248472.3) was significantly upregulated in the proliferative phase during liver regeneration. This indicate...

    Authors: Chunyan Zhang, Cuifang Chang, Deming Li, Fuchun Zhang and Cunshuan Xu
    Citation: Cellular & Molecular Biology Letters 2017 22:21
  34. Clinicians use clinical and pathological parameters, such as tumour size, grade and nodal status, to make decisions on adjuvant treatments for breast cancer. However, therapeutic decisions based on these featu...

    Authors: Umar Wazir, Kinan Mokbel, Amtul Carmichael and Kefah Mokbel
    Citation: Cellular & Molecular Biology Letters 2017 22:20
  35. One of the microorganisms from dental plaque associated with severe inflammatory responses in infectious endocarditis is Porphyromonas gingivalis. It is a Gram-negative bacteria harvested from chronic periodontit...

    Authors: Gloria Gutiérrez-Venegas, Alfredo Torras-Ceballos, Juan Arturo Gómez-Mora and Berenice Fernández-Rojas
    Citation: Cellular & Molecular Biology Letters 2017 22:19
  36. In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly of DNA-protein complex, ch...

    Authors: Sergey V. Razin and Sergey V. Ulianov
    Citation: Cellular & Molecular Biology Letters 2017 22:18
  37. Retinoblastoma (RB), a childhood cancer, is caused by biallelic mutation of the RB1 gene, but its development is not clearly understood. Furthermore, the presence of a cancer stem cell subpopulation in RB might i...

    Authors: Suganya Sivagurunathan, Jayamuruga Pandian Arunachalam and Subbulakshmi Chidambaram
    Citation: Cellular & Molecular Biology Letters 2017 22:17
  38. Nur-77, a member of the NR4A sub-family of nuclear orphan receptors, is downregulated in the placentae of pre-eclamptic women. Here, we investigate the relevance of Nor-1, Nurr-1 and Nur-77 in trophoblastic ce...

    Authors: Sudha Saryu Malhotra and Satish Kumar Gupta
    Citation: Cellular & Molecular Biology Letters 2017 22:15
  39. Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs ...

    Authors: Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong and Zhaochen Shan
    Citation: Cellular & Molecular Biology Letters 2017 22:14
  40. FFA1 is abundantly expressed in the liver, skeletal muscle, monocytes and nervous system, but is particularly abundant in pancreatic β cells. It is widely believed that FFA1 exerts its regulatory roles in a va...

    Authors: Jing Qian, Yuyang Gu, Chun Wu, Feng Yu, Yuqi Chen, Jingmei Zhu, Xingyi Yao, Chen Bei and Qingqing Zhu
    Citation: Cellular & Molecular Biology Letters 2017 22:13
  41. MicroRNAs (miRNAs) play important roles in the growth and metastasis of colon cancer. It is known that one set of miRNAs are dysregulated in colon cancer cells, but the mechanism of their role in cancer develo...

    Authors: Mingxi Zeng, Linlin Zhu, Liangping Li and Changming Kang
    Citation: Cellular & Molecular Biology Letters 2017 22:12
  42. Human milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to proteins, lipids, carbohydrates and other biologically active components, breast milk contain...

    Authors: Malgorzata Witkowska-Zimny and Ewa Kaminska-El-Hassan
    Citation: Cellular & Molecular Biology Letters 2017 22:11
  43. H19 is a well-characterized Long noncoding RNA (lncRNA) that has been proven to promote myoblast differentiation in humans and mice. However, its mechanism of action is still not fully interpreted.

    Authors: Xiaochun Xu, Shengyue Ji, Weili Li, Bao Yi, Hengxin Li, Hongfu Zhang and Wenping Ma
    Citation: Cellular & Molecular Biology Letters 2017 22:10
  44. The gene that encodes tumor protein p53, Tp53, is mutated or silenced in most human cancers and is recognized as one of the most important cancer drivers. Homozygotic Tp53 knockout mice, which develop lethal canc...

    Authors: Damian Strzemecki, Magdalena Guzowska and Paweł Grieb
    Citation: Cellular & Molecular Biology Letters 2017 22:9
  45. Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggr...

    Authors: Zakir Khan, Abdul Arif Khan, Hariom Yadav, Godavarthi B. K. S. Prasad and Prakash Singh Bisen
    Citation: Cellular & Molecular Biology Letters 2017 22:8
  46. Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists. It is caused by inactivating mutat...

    Authors: Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino and Faustino Bisaccia
    Citation: Cellular & Molecular Biology Letters 2017 22:7
  47. Although the 3T3-L1 preadipocyte cell line represents an informative model for in vitro adipogenesis research, primary cultured cells are often needed to understand particular human or animal metabolic phenotypes...

    Authors: Yong Pu and Almudena Veiga-Lopez
    Citation: Cellular & Molecular Biology Letters 2017 22:6
  48. Human Tenon’s fibroblasts (HTFs) play a crucial role in wound healing. They cause postoperative scarring of the filtering bleb and are thus responsible for trabeculectomy failure. This study aimed to find an e...

    Authors: Agata Przekora, Tomasz Zarnowski and Grazyna Ginalska
    Citation: Cellular & Molecular Biology Letters 2017 22:5

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