|
MicA/ompA
|
Escherichia coli
|
Direct (TIR) inhibition of translation
|
Trans-encoded; entails RNase E-dependent mRNA decay
|
Yes
|
|
SgrS/ptsG
|
E. coli
|
Direct (TIR) inhibition of translation
|
Trans-encoded; SgrS also encoded o protein
|
Yes
|
|
CopA/CopT
|
E. coli R1-type plasmids
|
Inhibition of translation
|
Cis-encoded; involves translational coupling
|
No
|
|
IstR1/tisB
|
E. coli
|
Inhibition of translation
|
Trans-encoded; binding upstream of TIR inhibits standby ribosomes
|
No
|
|
RNAIII/sa1000
|
Staphylococcus aureus
|
Inhibition of translational initiation and induced RNase III cleavage
|
Trans-encoded; full inhibition requires both translation block and endocleavage; also contain open reading frame
|
No
|
|
DsrA/rpoS
|
E. coli
|
Activation of RpoS translation
|
Trans-encoded; binding upstream of TIR
|
Yes
|
|
RNAIII/repR
|
Streptococci plasmid plP501
|
Riboswitch-like induction of premature transcription termination
|
Cis-encoded
|
?
|
|
GadY/gadXY
|
E. coli
|
Induced cleavage, stabilization of gadX mRNA
|
Cis-encoded between gadX and gadY
|
Yes
|
|
OOP/cll
|
E. coli Lambda phage
|
Induced RNase III-mediated cleavage near 3’ end
|
Cis-encoded; causes subsequent cll mRNA decay
|
?
|
|
MicC/ompD
|
Salmonella
|
Direct targeting for mRNA decay
|
CDS-internal target; no effect on translational initiation
|
Yes
|
|
RNAI/RNAII
|
E. coli ColE1-type plasmids
|
Inhibition of replication primer maturation
|
Cis-encoded; induces RNA folding change
|
No
|
|
crRNAs/phage RNA/DNA?
|
Bacteria and archea
|
Mechanism is homology-dependent but unknown
|
CrRNAs processed from precursor RNA; anti-phage immunity
|
?
|
