Microcystins are waterborne environmental toxins that induce oxidative stress and cause injuries in the heart. On the other hand, many physiological processes, including antioxidant defense, are under precise ...
Authors: Yonghua Xu, Xiangmin Wang, Surong Jiang, Chen Men, Di Xu, Yan Guo and Jun Wu
To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown...
Tissue ischemia can arise in response to numerous physiologic and pathologic conditions. The cellular response to decreased perfusion, most notably a decrease in glucose and oxygen, is important for cellular s...
Authors: Grey W Fortenbery, Brinda Sarathy, Kristen R Carraway and Kyle D Mansfield
Evidence has shown that endogenous H2S plays an important role in the physiological and pathophysiological processes of many organs. The study aimed to explore whether exogenous H2S has a potential therapeutic ef...
Authors: Zhong-Shi Xu, Feng Dai, Ji Chen, Meng Lv, Ji-Wu Cheng, Xiao-Ming Zhang and Bo-Wen Lin
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. The 5-year survival rate remains low despite considerable research into treatme...
Authors: Maoyun Fei, Jianming Guan, Tao Xue, Lianjin Qin, Chengwu Tang, Ge Cui, Yao Wang, Hui Gong and Wenming Feng
Recent developments in high-throughput genotyping technologies have revealed the existence of several new classes of RNA that do not encode proteins but serve other cellular roles. To date, these non-coding RN...
Authors: Rafal Bartoszewski and Aleksander F. Sikorski
Tumor microenvironment, in particular the stroma, plays an important role in breast cancer cell invasion and metastasis. Investigation of the molecular characteristics of breast cancer stroma may reveal target...
Authors: Yanxia Wang, Hui Xu, Baoan Zhu, Zhenling Qiu and Zaijun Lin
Lnc-DC is a specific group of long non-coding (Lnc) RNAs in dendritic cells (DCs). Its function has been previously studied, and includes roles in dendritic cell differentiation and the progression of some dis...
Authors: Lifan Zhuang, Jianhua Tian, Xinzhi Zhang, Hong Wang and Chenghui Huang
Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer, with a poor prognosis. Deregulation of WNT and NOTCH signaling pathways is important in ESCC progression, wh...
Authors: Mohammad Reza Abbaszadegan, Anali Riahi, Mohammad Mahdi Forghanifard and Meysam Moghbeli
MicroRNAs play important roles in regulation of the cardiovascular system. The purpose of this study was to investigate microRNA-320 (miR-320) expression in myocardial ischemia-reperfusion (I/R) injury and the...
Authors: Zhi-Qiang Tian, Hong Jiang and Zhi-Bing Lu
Imbalances in circulating T lymphocytes play critical roles in the pathogenesis of hypertension-mediated inflammation. Connexins (Cxs) in immune cells are involved in the maintenance of homeostasis of T lympho...
Authors: Xin Ni, Xin-zhi Li, Zhi-ru Fan, Ai Wang, Hai-chao Zhang, Liang Zhang, Li LI, Jun-qiang Si and Ke-tao Ma
The transcription factor Oct4 plays a pivotal role in the pre-implantation development of the mouse embryo. DNA methyltransferase 1 (Dnmt1) maintains the changes in DNA methylation during mammalian early embry...
Authors: Fengrui Wu, Qingqing Wu, Dengkun Li, Yuan Zhang, Rong Wang, Yong Liu and Wenyong Li
Inflammation is an important pathogenic component of endotoxemia-induced acute kidney injury (AKI), finally resulting in renal failure. Diacerein is an interleukin-1β (IL-1β) inhibitor used for osteoarthritis ...
Authors: Guangzhe Yu, Qian Liu, Xuening Dong, Kaihong Tang, Bohui Li, Chunmei Liu, Wenzheng Zhang, Yiduo Wang and Yingyu Jin
Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex tha...
The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the expression of multiple genes. Its non-genomic function is largely related to its structure, polymeric forms and mo...
Authors: Liqun Chen, Lingjuan Wu, Linyan Zhu and Yiyi Zhao
Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may the...
Recent findings indicate that dentin sialophosphoprotein (DSPP) and matrix metalloproteinase (MMP) 20 interact in oral squamous cell carcinoma (OSCC). The objective of this study was to determine the effects o...
Authors: Nikolaos G. Nikitakis, Ioannis Gkouveris, Jaya Aseervatham, Kelvin Barahona and Kalu U. E. Ogbureke
Osteosarcoma (OS) is a common malignant tumor that predominantly occurs in adolescents. Its most common metastasis is to the lungs. As shown in our earlier study, lysosome-associated membrane glycoprotein 3 (L...
Authors: Shaoxian Liu, Junyi Yue, Wei Du, Jian Han and Weidong Zhang
Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins ...
Authors: Marta Pałka, Aleksandra Tomczak, Katarzyna Grabowska, Magdalena Machowska, Katarzyna Piekarowicz, Dorota Rzepecka and Ryszard Rzepecki
Bamei pigs are special germplasm resources in Qinghai. In the specific environment of the Qinghai plateau, local breeds, through long-term natural and artificial selection, have acquired a relatively stable po...
Authors: Junxia Zhang, Baochun Yang, Xiaocheng Wen and Guoqiang Sun
Mishandling of intracellular chloride (Cl−) concentration ([Cl−]i) in cerebrovascular smooth muscle cells is implicated in several pathological processes, including hyperplasia and remodeling. We investigated the...
Authors: Jingjing Lu, Feng Xu, Yingna Zhang, Hong Lu and Jiewen Zhang
It has been reported that the expression of activating transcription factor 3 (ATF3) is closely associated with both microRNA (miRNA) processing and the progress of many cancers. Our study aimed to explore the...
Authors: Bingxia Shi, Wei Yan, Guolin Liu and Yanjun Guo
Radiotherapy is among the commonly applied treatment options for glioma, which is one of the most common types of primary brain tumor. To evaluate the effect of radiotherapy noninvasively, it is vital for onco...
Authors: Hongxia Li, Yi Cui, Fuyan Li, Wenqi Shi, Wenjing Gao, Xiao Wang and Qingshi Zeng
Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-1α) is an important mediator of the hypoxia response. It regulates the expression of various chemokines involved in tumor growth,...
Authors: Wenming Feng, Tao Xue, Sanxiong Huang, Qilin Shi, Chengwu Tang, Ge Cui, Guanghui Yang, Hui Gong and Huihui Guo
Although significant advances have been made in understanding the mechanisms of macrophage response to Staphylococcus aureus infection, the molecular details are still elusive. Identification of the essential gen...
Patients with anti-β2GPI antibodies display significantly higher platelet activation/aggregation and vascular endothelial cell damage. The mechanism underlying the correlation between platelet activation, vasc...
Authors: Yanfen Zhang, Wenjing Zhang, Caijun Zha and Yanhong Liu
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 ...
MicroRNAs (miRNAs) have physiological and pathophysiological functions that are involved in the regulation of cardiac fibrosis. This study aimed to investigate the effects of miR-495 on high glucose-induced ca...
Authors: Xiaowei Wang, Haiying Jin, Shifeng Jiang and Yanlan Xu
Post-infarction cardiac injury is closely associated with cardiac remodeling and heart dysfunction. Mammalian STE20-like kinase 1 (Mst1), a regulator of cellular apoptosis, is involved in cardiac remodeling in...
Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearl...
Authors: Mokgadi Violet Gwangwa, Anna Margaretha Joubert and Michelle Helen Visagie
Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored...
Authors: Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang and Ming Yang
Lycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP...
Authors: Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li and Huilan Zhu
Epstein–Barr virus (EBV) infection is causatively associated with a variety of human cancers, including gastric cancer (GC), which has one of the highest mortality rates of all human cancers. Long non-coding R...
Authors: Jing Liu, Chunxia Yang, Yufang Gu, Chong Li, Huamei Zhang, Wenfang Zhang, Xueqing Wang, Nan Wu and Chunyan Zheng
The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the i...
Authors: Gabriela Sánchez, Omar Estrada, Giovana Acha, Alfonso Cardozo, Franshelle Peña, Marie Christine Ruiz, Fabián Michelangeli and Claudia Alvarado-Castillo
The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal e...
Authors: Ruijie Gong, Xiaofei Lv and Fengqiong Liu
The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, w...
Authors: Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang and Heng Wu
Arsenic trioxide (As2O3) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2O3 has an antitumo...
Authors: Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai and Kongbin Yang
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is invo...
Authors: Michaela Galoczova, Philip Coates and Borivoj Vojtesek
The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against num...
Authors: Laura Susan Boyd, Devrim Gozuacik and Anna Margaretha Joubert
Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate i...
Authors: Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh and Majd Aljamali
Previous studies indicated that cadmium (Cd) increases PI3-kinase/Akt phosphorylation, resulting in an alteration in GSK-3β activity. However, the mechanism of Cd-induced endoplasmic reticulum (ER) stress in n...
Authors: Seungwoo Kim, Hyosoon Cheon, Sam-Moon Kim and Young-Youl Kim
Platelet-derived growth factor-C (PDGF-C) has been shown to be involved in several biological processes, such as embryonic development, wound healing and angiogenesis, as well as in diseases including tumor fo...
Authors: Tomoaki Kinjo, Chuanhai Sun, Tomomi Ikeda, Takako Ikegami, Yuhki Tada, Tadayuki Akagi, Takashi Yokota and Hiroshi Koide
Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, i...
Authors: Hao Yang, Di Wu, Hua Li, Nan Chen and Yongjun Shang
Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene...
Authors: Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li and Xiaohui Zhang
Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteo...
Authors: Nazli F. Eskici, Sevim Erdem-Ozdamar and Didem Dayangac-Erden
Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. However, the effects of CGRP ...
Authors: Shaohua Wang, Hongxing Dang, Feng Xu, Jian Deng and Xuemei Zheng
Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to...
Authors: Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Shoukath M. Ali, Moghis U. Ahmad and Imran Ahmad
Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects....
Authors: Ying Chen, Lei Zhang, Wen-xin Liu and Ke Wang
Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apop...
Authors: Yanan Li, Yu Yan, Fang Liu, Ming Wang, Fumin Feng and Yonghong Xiao
