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  1. Content type: Research

    Adjuvant chemotherapy has become the frequently adopted standard therapeutic approach for non-small cell lung cancer (NSCLC). However, the development of multidrug resistance (MDR) is a major obstacle contribu...

    Authors: Huaping Huang, Tangying Li, Mingjing Chen, Feng Liu, Haifeng Wu, Jie Wang, Jialiang Chen and Xi Li

    Citation: Cellular & Molecular Biology Letters 2018 23:54

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  2. Content type: Short report

    Oral cancer remains a deadly disease worldwide. Lymph node metastasis and invasion is one of the causes of death from oral cancer. Elucidating the mechanism of oral cancer lymph node metastasis and identifying...

    Authors: Xing’an Zhang, Lanfang Zhang, Xiaoyao Tan, Ying Lin, Xinsheng Han, Huadong Wang, Huawei Ming, Qiujiang Li, Kang Liu and Gang Feng

    Citation: Cellular & Molecular Biology Letters 2018 23:53

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  3. Content type: Research

    Pulmonary inflammation and endothelial barrier permeability increase in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) induced by pro-inflammatory cytokines and matrix metalloproteinase...

    Authors: Yafeng Liang, Nengli Yang, Guoquan Pan, Bingxin Jin, Shufen Wang and Wei Ji

    Citation: Cellular & Molecular Biology Letters 2018 23:52

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  4. Content type: Research

    Breast cancer is the most prevalent cancer among women, and AXL and MET are the key genes in the PI3K/AKT/mTOR pathway as critical elements in proliferation and invasion of cancer cells. MicroRNAs (miRNAs) are sm...

    Authors: Shadan Hajalirezay Yazdi, Mahdi Paryan and Samira Mohammadi-Yeganeh

    Citation: Cellular & Molecular Biology Letters 2018 23:51

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  5. Content type: Short report

    Microcystins are waterborne environmental toxins that induce oxidative stress and cause injuries in the heart. On the other hand, many physiological processes, including antioxidant defense, are under precise ...

    Authors: Yonghua Xu, Xiangmin Wang, Surong Jiang, Chen Men, Di Xu, Yan Guo and Jun Wu

    Citation: Cellular & Molecular Biology Letters 2018 23:50

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  6. Content type: Mini review

    To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown...

    Authors: Toru Miyanaga, Yoshimichi Ueda, Aiko Miyanaga, Mikio Yagishita and Naoko Hama

    Citation: Cellular & Molecular Biology Letters 2018 23:49

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  7. Content type: Research

    Tissue ischemia can arise in response to numerous physiologic and pathologic conditions. The cellular response to decreased perfusion, most notably a decrease in glucose and oxygen, is important for cellular s...

    Authors: Grey W Fortenbery, Brinda Sarathy, Kristen R Carraway and Kyle D Mansfield

    Citation: Cellular & Molecular Biology Letters 2018 23:48

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  8. Content type: Research

    Evidence has shown that endogenous H2S plays an important role in the physiological and pathophysiological processes of many organs. The study aimed to explore whether exogenous H2S has a potential therapeutic ef...

    Authors: Zhong-Shi Xu, Feng Dai, Ji Chen, Meng Lv, Ji-Wu Cheng, Xiao-Ming Zhang and Bo-Wen Lin

    Citation: Cellular & Molecular Biology Letters 2018 23:47

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  9. Content type: Short report

    Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. The 5-year survival rate remains low despite considerable research into treatme...

    Authors: Maoyun Fei, Jianming Guan, Tao Xue, Lianjin Qin, Chengwu Tang, Ge Cui, Yao Wang, Hui Gong and Wenming Feng

    Citation: Cellular & Molecular Biology Letters 2018 23:46

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  10. Content type: Mini review

    Recent developments in high-throughput genotyping technologies have revealed the existence of several new classes of RNA that do not encode proteins but serve other cellular roles. To date, these non-coding RN...

    Authors: Rafal Bartoszewski and Aleksander F. Sikorski

    Citation: Cellular & Molecular Biology Letters 2018 23:45

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  11. Content type: Short report

    Tumor microenvironment, in particular the stroma, plays an important role in breast cancer cell invasion and metastasis. Investigation of the molecular characteristics of breast cancer stroma may reveal target...

    Authors: Yanxia Wang, Hui Xu, Baoan Zhu, Zhenling Qiu and Zaijun Lin

    Citation: Cellular & Molecular Biology Letters 2018 23:44

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  12. Content type: Short report

    Lnc-DC is a specific group of long non-coding (Lnc) RNAs in dendritic cells (DCs). Its function has been previously studied, and includes roles in dendritic cell differentiation and the progression of some dis...

    Authors: Lifan Zhuang, Jianhua Tian, Xinzhi Zhang, Hong Wang and Chenghui Huang

    Citation: Cellular & Molecular Biology Letters 2018 23:43

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  13. Content type: Short report

    Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer, with a poor prognosis. Deregulation of WNT and NOTCH signaling pathways is important in ESCC progression, wh...

    Authors: Mohammad Reza Abbaszadegan, Anali Riahi, Mohammad Mahdi Forghanifard and Meysam Moghbeli

    Citation: Cellular & Molecular Biology Letters 2018 23:42

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  14. Content type: Research

    MicroRNAs play important roles in regulation of the cardiovascular system. The purpose of this study was to investigate microRNA-320 (miR-320) expression in myocardial ischemia-reperfusion (I/R) injury and the...

    Authors: Zhi-Qiang Tian, Hong Jiang and Zhi-Bing Lu

    Citation: Cellular & Molecular Biology Letters 2018 23:41

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  15. Content type: Research

    Imbalances in circulating T lymphocytes play critical roles in the pathogenesis of hypertension-mediated inflammation. Connexins (Cxs) in immune cells are involved in the maintenance of homeostasis of T lympho...

    Authors: Xin Ni, Xin-zhi Li, Zhi-ru Fan, Ai Wang, Hai-chao Zhang, Liang Zhang, Li LI, Jun-qiang Si and Ke-tao Ma

    Citation: Cellular & Molecular Biology Letters 2018 23:40

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  16. Content type: Research

    The transcription factor Oct4 plays a pivotal role in the pre-implantation development of the mouse embryo. DNA methyltransferase 1 (Dnmt1) maintains the changes in DNA methylation during mammalian early embry...

    Authors: Fengrui Wu, Qingqing Wu, Dengkun Li, Yuan Zhang, Rong Wang, Yong Liu and Wenyong Li

    Citation: Cellular & Molecular Biology Letters 2018 23:39

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  17. Content type: Research

    Inflammation is an important pathogenic component of endotoxemia-induced acute kidney injury (AKI), finally resulting in renal failure. Diacerein is an interleukin-1β (IL-1β) inhibitor used for osteoarthritis ...

    Authors: Guangzhe Yu, Qian Liu, Xuening Dong, Kaihong Tang, Bohui Li, Chunmei Liu, Wenzheng Zhang, Yiduo Wang and Yingyu Jin

    Citation: Cellular & Molecular Biology Letters 2018 23:38

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  18. Content type: Short report

    Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex tha...

    Authors: Wei Wu, Li Nie, Li Zhang and Yan Li

    Citation: Cellular & Molecular Biology Letters 2018 23:37

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  19. Content type: Short report

    Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may the...

    Authors: Ying Huang, Wuping Yang, Huihong Zeng, Chuan Hu, Yaqiong Zhang, Nanhua Ding, Guangqin Fan, Lijian Shao and Bohai Kuang

    Citation: Cellular & Molecular Biology Letters 2018 23:34

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  20. Content type: Short report

    Recent findings indicate that dentin sialophosphoprotein (DSPP) and matrix metalloproteinase (MMP) 20 interact in oral squamous cell carcinoma (OSCC). The objective of this study was to determine the effects o...

    Authors: Nikolaos G. Nikitakis, Ioannis Gkouveris, Jaya Aseervatham, Kelvin Barahona and Kalu U. E. Ogbureke

    Citation: Cellular & Molecular Biology Letters 2018 23:30

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  21. Content type: Review

    Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins ...

    Authors: Marta Pałka, Aleksandra Tomczak, Katarzyna Grabowska, Magdalena Machowska, Katarzyna Piekarowicz, Dorota Rzepecka and Ryszard Rzepecki

    Citation: Cellular & Molecular Biology Letters 2018 23:32

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  22. Content type: Short report

    Bamei pigs are special germplasm resources in Qinghai. In the specific environment of the Qinghai plateau, local breeds, through long-term natural and artificial selection, have acquired a relatively stable po...

    Authors: Junxia Zhang, Baochun Yang, Xiaocheng Wen and Guoqiang Sun

    Citation: Cellular & Molecular Biology Letters 2018 23:31

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  23. Content type: Research

    Mishandling of intracellular chloride (Cl) concentration ([Cl]i) in cerebrovascular smooth muscle cells is implicated in several pathological processes, including hyperplasia and remodeling. We investigated the...

    Authors: Jingjing Lu, Feng Xu, Yingna Zhang, Hong Lu and Jiewen Zhang

    Citation: Cellular & Molecular Biology Letters 2018 23:29

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  24. Content type: Research

    Radiotherapy is among the commonly applied treatment options for glioma, which is one of the most common types of primary brain tumor. To evaluate the effect of radiotherapy noninvasively, it is vital for onco...

    Authors: Hongxia Li, Yi Cui, Fuyan Li, Wenqi Shi, Wenjing Gao, Xiao Wang and Qingshi Zeng

    Citation: Cellular & Molecular Biology Letters 2018 23:27

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  25. Content type: Short report

    Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-1α) is an important mediator of the hypoxia response. It regulates the expression of various chemokines involved in tumor growth,...

    Authors: Wenming Feng, Tao Xue, Sanxiong Huang, Qilin Shi, Chengwu Tang, Ge Cui, Guanghui Yang, Hui Gong and Huihui Guo

    Citation: Cellular & Molecular Biology Letters 2018 23:26

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  26. Content type: Research

    Although significant advances have been made in understanding the mechanisms of macrophage response to Staphylococcus aureus infection, the molecular details are still elusive. Identification of the essential gen...

    Authors: Aixia Sun, Hongwei Zhang, Feng Pang, Guifen Niu, Jianzhong Chen, Fei Chen and Jian Zhang

    Citation: Cellular & Molecular Biology Letters 2018 23:25

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  27. Content type: Short report

    Patients with anti-β2GPI antibodies display significantly higher platelet activation/aggregation and vascular endothelial cell damage. The mechanism underlying the correlation between platelet activation, vasc...

    Authors: Yanfen Zhang, Wenjing Zhang, Caijun Zha and Yanhong Liu

    Citation: Cellular & Molecular Biology Letters 2018 23:24

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  28. Content type: Short report

    The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 ...

    Authors: Jing-jing Zhao, Xiao-Li Lou, Hong-wei Chen, Feng-ting Zhu and Yan-Qiang Hou

    Citation: Cellular & Molecular Biology Letters 2018 23:22

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  29. Content type: Research

    MicroRNAs (miRNAs) have physiological and pathophysiological functions that are involved in the regulation of cardiac fibrosis. This study aimed to investigate the effects of miR-495 on high glucose-induced ca...

    Authors: Xiaowei Wang, Haiying Jin, Shifeng Jiang and Yanlan Xu

    Citation: Cellular & Molecular Biology Letters 2018 23:23

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  30. Content type: Review

    Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearl...

    Authors: Mokgadi Violet Gwangwa, Anna Margaretha Joubert and Michelle Helen Visagie

    Citation: Cellular & Molecular Biology Letters 2018 23:20

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  31. Content type: Short report

    Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored...

    Authors: Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang and Ming Yang

    Citation: Cellular & Molecular Biology Letters 2018 23:19

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  32. Content type: Short report

    Lycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP...

    Authors: Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li and Huilan Zhu

    Citation: Cellular & Molecular Biology Letters 2018 23:18

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  33. Content type: Research

    Epstein–Barr virus (EBV) infection is causatively associated with a variety of human cancers, including gastric cancer (GC), which has one of the highest mortality rates of all human cancers. Long non-coding R...

    Authors: Jing Liu, Chunxia Yang, Yufang Gu, Chong Li, Huamei Zhang, Wenfang Zhang, Xueqing Wang, Nan Wu and Chunyan Zheng

    Citation: Cellular & Molecular Biology Letters 2018 23:17

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  34. Content type: Research

    The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the i...

    Authors: Gabriela Sánchez, Omar Estrada, Giovana Acha, Alfonso Cardozo, Franshelle Peña, Marie Christine Ruiz, Fabián Michelangeli and Claudia Alvarado-Castillo

    Citation: Cellular & Molecular Biology Letters 2018 23:15

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  35. Content type: Short report

    The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal e...

    Authors: Ruijie Gong, Xiaofei Lv and Fengqiong Liu

    Citation: Cellular & Molecular Biology Letters 2018 23:16

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  36. Content type: Research

    The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, w...

    Authors: Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang and Heng Wu

    Citation: Cellular & Molecular Biology Letters 2018 23:14

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  37. Content type: Research

    Arsenic trioxide (As2O3) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2O3 has an antitumo...

    Authors: Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai and Kongbin Yang

    Citation: Cellular & Molecular Biology Letters 2018 23:13

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  38. Content type: Review

    Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is invo...

    Authors: Michaela Galoczova, Philip Coates and Borivoj Vojtesek

    Citation: Cellular & Molecular Biology Letters 2018 23:12

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  39. Content type: Research

    The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against num...

    Authors: Laura Susan Boyd, Devrim Gozuacik and Anna Margaretha Joubert

    Citation: Cellular & Molecular Biology Letters 2018 23:10

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  40. Content type: Short report

    Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate i...

    Authors: Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh and Majd Aljamali

    Citation: Cellular & Molecular Biology Letters 2018 23:11

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  41. Content type: Short report

    Previous studies indicated that cadmium (Cd) increases PI3-kinase/Akt phosphorylation, resulting in an alteration in GSK-3β activity. However, the mechanism of Cd-induced endoplasmic reticulum (ER) stress in n...

    Authors: Seungwoo Kim, Hyosoon Cheon, Sam-Moon Kim and Young-Youl Kim

    Citation: Cellular & Molecular Biology Letters 2018 23:9

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  42. Content type: Research

    Platelet-derived growth factor-C (PDGF-C) has been shown to be involved in several biological processes, such as embryonic development, wound healing and angiogenesis, as well as in diseases including tumor fo...

    Authors: Tomoaki Kinjo, Chuanhai Sun, Tomomi Ikeda, Takako Ikegami, Yuhki Tada, Tadayuki Akagi, Takashi Yokota and Hiroshi Koide

    Citation: Cellular & Molecular Biology Letters 2018 23:8

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  43. Content type: Research

    Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, i...

    Authors: Hao Yang, Di Wu, Hua Li, Nan Chen and Yongjun Shang

    Citation: Cellular & Molecular Biology Letters 2018 23:7

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