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  1. Deer antlers have become a valuable model for biomedical research due to the capacities of regeneration and rapid growth. However, the molecular mechanism of rapid antler growth remains to be elucidated. The a...

    Authors: Baojin Yao, Chaonan Wang, Zhenwei Zhou, Mei Zhang, Daqing Zhao, Xueyuan Bai and Xiangyang Leng

    Citation: Cellular & Molecular Biology Letters 2020 25:42

    Content type: Research Letter

    Published on:

  2. The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in t...

    Authors: Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp and Borivoj Vojtesek

    Citation: Cellular & Molecular Biology Letters 2020 25:41

    Content type: Research

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  3. Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown...

    Authors: Kota Ogawa, Akiko Noda, Jun Ueda, Takehiro Ogata, Rumiko Matsuyama, Yuji Nishizawa, Shanlou Qiao, Satoru Iwata, Morihiro Ito, Yoshitaka Fujihara, Masatoshi Ichihara, Koichi Adachi, Yuji Takaoka and Takashi Iwamoto

    Citation: Cellular & Molecular Biology Letters 2020 25:40

    Content type: Research

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  4. Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the anim...

    Authors: Shuhei Yamada

    Citation: Cellular & Molecular Biology Letters 2020 25:39

    Content type: Review Letter

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  5. Daxx is a highly conserved nuclear protein with an important role in transcription, apoptosis and other cell processes. We investigated the role of HPV16 E6 in Daxx-induced apoptosis through their interactions...

    Authors: Shuangyang Tang, Shuang Ding, Lan Yu, Haiyan Shen, Yanping Wan and Yimou Wu

    Citation: Cellular & Molecular Biology Letters 2020 25:38

    Content type: Research Letter

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  6. The plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical prope...

    Authors: Ambroise Wu, Karolina Wojtowicz, Stephane Savary, Yannick Hamon and Tomasz Trombik

    Citation: Cellular & Molecular Biology Letters 2020 25:37

    Content type: Invited Review

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  7. Rhomboid domain containing 1 (RHBDD1) plays a crucial role in tumorigenesis. Silibinin, which is a natural extract from milk thistle, has shown anti-tumor effects against various tumors. Here, we investigate w...

    Authors: Suyan Xu, Hongyan Zhang, Aifeng Wang, Yongcheng Ma, Yuan Gan and Guofeng Li

    Citation: Cellular & Molecular Biology Letters 2020 25:36

    Content type: Research Letter

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  8. One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associat...

    Authors: Agata Forkasiewicz, Maja Dorociak, Kamilla Stach, Piotr Szelachowski, Renata Tabola and Katarzyna Augoff

    Citation: Cellular & Molecular Biology Letters 2020 25:35

    Content type: Invited Review Letter

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  9. Peritoneal fibrosis (PF) is a frequent complication caused by peritoneal dialysis (PD). Peritoneal mesothelial cells (PMCs), the first barrier of the peritoneum, play an important role in maintaining structure...

    Authors: Junyi Zhao, Jun Shi, Yun Shan, Manshu Yu, Xiaolin Zhu, Yilin Zhu, Li Liu and Meixiao Sheng

    Citation: Cellular & Molecular Biology Letters 2020 25:33

    Content type: Research

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  10. Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well...

    Authors: Magdalena Przybyło and Marek Langner

    Citation: Cellular & Molecular Biology Letters 2020 25:32

    Content type: Invited Review

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  11. Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a potent vasoconstrictor. Because of it...

    Authors: Duo-Yao Cao, Suguru Saito, Luciana C. Veiras, Derick Okwan-Duodu, Ellen A. Bernstein, Jorge F. Giani, Kenneth E. Bernstein and Zakir Khan

    Citation: Cellular & Molecular Biology Letters 2020 25:31

    Content type: Invited Review Letter

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  12. Dysregulation of the proliferation and migration of vascular smooth muscle cells (VSMCs) is a crucial cause of atherosclerosis. MiR-637 exerts an antiproliferative effect on multiple human cells. Its impact on...

    Authors: Ning Yang, Bo Dong, Yanqiu Song, Yang Li, Lu Kou, Jingyu Yang and Qin Qin

    Citation: Cellular & Molecular Biology Letters 2020 25:30

    Content type: Research Letter

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  13. Long non-coding RNA (lncRNA) as a widespread and pivotal epigenetic molecule participates in the occurrence and progression of malignant tumors. DRAIC, a kind of lncRNA whose coding gene location is on 15q23 c...

    Authors: Zheng Zhang, Xiaoxuan Hu, Jia Kuang, Jinmao Liao and Qi Yuan

    Citation: Cellular & Molecular Biology Letters 2020 25:29

    Content type: Research

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  14. Adoptive T-cell therapy (ACT) using autologous tumor-reactive T lymphocytes has considerable potential for cancer immunotherapy. In ACT, T cells are isolated from cancer patients and then stimulated and expand...

    Authors: Salman Bagheri, Elmira Safaie Qamsari, Mehdi Yousefi, Farhad Riazi-Rad and Zahra Sharifzadeh

    Citation: Cellular & Molecular Biology Letters 2020 25:28

    Content type: Research Letter

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  15. MicroRNA dysregulation occurs in many human diseases, including atherosclerosis. Here, we examined the serum expression and clinical significance of miR-186-5p in patients with atherosclerosis, and explored it...

    Authors: Bin Sun, Qingtao Cao, Meng Meng and Xiaolong Wang

    Citation: Cellular & Molecular Biology Letters 2020 25:27

    Content type: Research Letter

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  16. Oxidative stress results in cell apoptosis/death and plays a detrimental role in disease development and progression. Stressors alter the miRNA expression profile and miRNAs play a role in the cell response to...

    Authors: Duo Zhao, Hao Zheng, Adam Greasley, Fengjun Ling, Qinfeng Zhou, Bowen Wang, Tiffany Ni, Ishita Topiwala, Cuilin Zhu, Tina Mele, Kexiang Liu and Xiufen Zheng

    Citation: Cellular & Molecular Biology Letters 2020 25:26

    Content type: Research

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  17. Cervical cancer remains the second leading cause of mortality in women in developing countries. While surgery, chemotherapy, radiotherapy, and vaccine therapy are being applied for its treatment, individually ...

    Authors: Chenglai Xia, Zhihong He and Yantao Cai

    Citation: Cellular & Molecular Biology Letters 2020 25:25

    Content type: Research Letter

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  18. A huge array of function is played by the Wnt/β-catenin signaling pathway in development by balancing gene expression through the modulation of cell-specific DNA binding downstream effectors such as T-cell fac...

    Authors: Mumtaz Anwar, Pooja Malhotra, Rakesh Kochhar, Alka Bhatia, Akhtar Mahmood, Rajinder Singh and Safrun Mahmood

    Citation: Cellular & Molecular Biology Letters 2020 25:24

    Content type: Research Letter

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  19. Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis. Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase-dependent apoptosis, which in ...

    Authors: Mehri Bemani Naeini, Vanessa Bianconi, Matteo Pirro and Amirhossein Sahebkar

    Citation: Cellular & Molecular Biology Letters 2020 25:23

    Content type: Invited Review Letter

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  20. Pulmonary arterial hypertension (PAH) is often characterized by cell proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). LncRNA cancer susceptibility candidate 2 (CASC2) has been re...

    Authors: Yan Han, Yuhao Liu, Chaokuan Yang, Chuanyu Gao, Xiaoyan Guo and Jiangtao Cheng

    Citation: Cellular & Molecular Biology Letters 2020 25:21

    Content type: Research

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  21. It has been shown that miR-144-3p regulates cell proliferation, apoptosis, migration and invasion in various cancers. However, the function and expression of miR-144-3p in colorectal cancer (CRC) remained obsc...

    Authors: Naihui Sun, Liang Zhang, Chongguang Zhang and Yuan Yuan

    Citation: Cellular & Molecular Biology Letters 2020 25:19

    Content type: Research

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  22. High levels of the post-translational modification O-GlcNAcylation (O-GlcNAc) are found in multiple cancers, including bladder cancer. Autophagy, which can be induced by stress from post-translational modifica...

    Authors: Lu Jin, Feng Yuan, Guangcheng Dai, Qiu Yao, Han Xiang, Lixia Wang, Boxin Xue, Yuxi Shan and Xiaolong Liu

    Citation: Cellular & Molecular Biology Letters 2020 25:17

    Content type: Research

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  23. Over the past decade, mesenchymal stromal cells (MSCs) found in the bone marrow microenvironment have been considered to be important candidates in cellular therapy. However, the application of MSCs in clinica...

    Authors: Jing Zhang, Yunsheng Liu, Wen Yin and Xingbin Hu

    Citation: Cellular & Molecular Biology Letters 2020 25:16

    Content type: Review Letter

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  24. Based on available metabolomic studies, influenza infection affects a variety of cellular metabolic pathways to ensure an optimal environment for its replication and production of viral particles. Following in...

    Authors: Mohsen Keshavarz, Farid Solaymani-Mohammadi, Haideh Namdari, Yaser Arjeini, Mohammad Javad Mousavi and Farhad Rezaei

    Citation: Cellular & Molecular Biology Letters 2020 25:15

    Content type: Review

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  25. MicroRNA-125b (miR-125b) is downregulated in human cutaneous squamous cell carcinoma (CSCC). However, its function in CSCC has yet to be extensively explored. Here, we analyze the relationship between signal t...

    Authors: Ke Tian, Wanggen Liu, Jing Zhang, Xiaoyi Fan, Jingyuan Liu, Nan Zhao, Chunxia Yao and Guoying Miao

    Citation: Cellular & Molecular Biology Letters 2020 25:12

    Content type: Research Letter

    Published on:

  26. Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced ...

    Authors: Pengfei Liu, Yetong Feng, Hanwei Li, Xin Chen, Guangsuo Wang, Shiyuan Xu, Yalan Li and Lei Zhao

    Citation: Cellular & Molecular Biology Letters 2020 25:10

    Content type: Research

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  27. Hepatocellular carcinoma (HCC) is still the most common cause of cancer-related mortality worldwide and accumulating studies report that HCC is frequently linked to chronic inflammation. G-protein alpha-subuni...

    Authors: Hongda Ding, Xixia Zhang, Yang Su, Changjun Jia and Chaoliu Dai

    Citation: Cellular & Molecular Biology Letters 2020 25:8

    Content type: Research

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  28. Viral myocarditis (VMC) is a type of cardiac inflammation that is generally caused by coxsackievirus B3 (CVB3) infection. Several MicroRNAs (miRNAs) are known to play crucial roles in VMC pathogenesis. MiR-15 ...

    Authors: Ru Tong, Tiewen Jia, Ruijie Shi and Futang Yan

    Citation: Cellular & Molecular Biology Letters 2020 25:6

    Content type: Research

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  29. MicroRNAs (miRNAs or miRs) can participate in the development and progression of neuroblastoma. Many studies have indicated that miR-429 can participate in tumor development. However, the mechanism underlying ...

    Authors: Xianjun Zhou, Hongting Lu, Fujiang Li, Xiwei Hao, Lulu Han, Qian Dong and Xin Chen

    Citation: Cellular & Molecular Biology Letters 2020 25:5

    Content type: Research

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  30. Precise coordination of cytoskeletal components and dynamic control of cell adhesion and migration are required for crucial cell processes such as differentiation and morphogenesis. We investigated the potenti...

    Authors: Beata Machnicka, Aurélie Ponceau, Julien Picot, Yves Colin and Marie-Christine Lecomte

    Citation: Cellular & Molecular Biology Letters 2020 25:3

    Content type: Research

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  31. This review focuses on DNA–dependent protein kinase (DNA–PK), which is the key regulator of canonical non–homologous end–joining (NHEJ), the predominant mechanism of DNA double–strand break (DSB) repair in mam...

    Authors: Jiangdong Sui, Shichuan Zhang and Benjamin P. C. Chen

    Citation: Cellular & Molecular Biology Letters 2020 25:2

    Content type: Review Letter

    Published on:

  32. Circular RNA (circRNA) has recently been considered as a key regulator in carcinogenesis. In this study, we investigated the functional significance and regulatory role of circ-CAMK2A (hsa_circ_0128332) in lun...

    Authors: Jiahui Du, Guangzhao Zhang, Hongli Qiu, Haifeng Yu and Wuying Yuan

    Citation: Cellular & Molecular Biology Letters 2019 24:72

    Content type: Research

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  33. Sex-determining region Y-box containing gene 30 (SOX30) is a newly identified tumor-associated gene in several types of cancer. However, whether SOX30 is involved in the development and progression of prostate...

    Authors: Qiang Fu, Zhenye Sun, Fan Yang, Tianci Mao, Yanyao Gao and He Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:71

    Content type: Research

    Published on:

  34. The expression level of miR-376c-3p is significantly lower in infants with neonatal hypoxic-ischemic encephalopathy (HIE) than in healthy infants. However, the biological function of this microRNA remains larg...

    Authors: Heng Zhang, Jie Zhou, Mingxia Zhang, Yanjie Yi and Bing He

    Citation: Cellular & Molecular Biology Letters 2019 24:67

    Content type: Research

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  35. MicroRNAs (miRNAs) function as post-transcriptional gene expression regulators. Some miRNAs, including the recently discovered miR-582–3p, have been implicated in leukemogenesis. This study aimed to reveal the...

    Authors: Haixia Li, Xuefei Tian, Paoqiu Wang, Mao Huang, Ronghua Xu and Tian Nie

    Citation: Cellular & Molecular Biology Letters 2019 24:66

    Content type: Research Letter

    Published on:

  36. Hypoestrogenism in women is strongly associated with menopause and it can lead to lipid disorder, which predisposes people to premature cardiovascular disease. However, the mechanism of lipid disorder remains ...

    Authors: Ye Meng and Lu Zong

    Citation: Cellular & Molecular Biology Letters 2019 24:65

    Content type: Research Letter

    Published on:

  37. Hypoxia in the vicinity of bone defects triggers the osteogenic differentiation of precursor cells and promotes healing. The activation of STAT3 signaling in mesenchymal stem cells (MSCs) has similarly been re...

    Authors: Xin Yu, Qilong Wan, Xiaoling Ye, Yuet Cheng, Janak L. Pathak and Zubing Li

    Citation: Cellular & Molecular Biology Letters 2019 24:64

    Content type: Research

    Published on:

  38. The participation of long noncoding RNAs (lncRNAs) in myocardial infarction has recently been noted. However, their underlying roles in the border zone of myocardial infarction remain unclear. This study uses ...

    Authors: Qingkun Meng, Zhijun Sun, Hui Gu, Jiaying Luo, Jingjing Wang, Chuanhe Wang and Su Han

    Citation: Cellular & Molecular Biology Letters 2019 24:63

    Content type: Research Letter

    Published on:

  39. Myocardial ischaemia reperfusion injury (MIRI) is a difficult problem in clinical practice, and it may involve various microRNAs. This study investigated the role that endogenous microRNA-146a plays in myocard...

    Authors: Tiantian Zhang, Yiwen Ma, Lin Gao, Chengyu Mao, Huasu Zeng, Xiaofei Wang, Yapin Sun, Jianmin Gu, Yue Wang, Kan Chen, Zhihua Han, Yuqi Fan, Jun Gu, Junfeng Zhang and Changqian Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:62

    Content type: Research

    Published on:

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