Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex tha...
The nuclear receptor RXRα (retinoid X receptor-α) is a transcription factor that regulates the expression of multiple genes. Its non-genomic function is largely related to its structure, polymeric forms and mo...
Authors: Liqun Chen, Lingjuan Wu, Linyan Zhu and Yiyi Zhao
Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may the...
Recent findings indicate that dentin sialophosphoprotein (DSPP) and matrix metalloproteinase (MMP) 20 interact in oral squamous cell carcinoma (OSCC). The objective of this study was to determine the effects o...
Authors: Nikolaos G. Nikitakis, Ioannis Gkouveris, Jaya Aseervatham, Kelvin Barahona and Kalu U. E. Ogbureke
Osteosarcoma (OS) is a common malignant tumor that predominantly occurs in adolescents. Its most common metastasis is to the lungs. As shown in our earlier study, lysosome-associated membrane glycoprotein 3 (L...
Authors: Shaoxian Liu, Junyi Yue, Wei Du, Jian Han and Weidong Zhang
Lamin proteins are type V intermediate filament proteins (IFs) located inside the cell nucleus. They are evolutionarily conserved and have similar domain organization and properties to cytoplasmic IFs. Lamins ...
Authors: Marta Pałka, Aleksandra Tomczak, Katarzyna Grabowska, Magdalena Machowska, Katarzyna Piekarowicz, Dorota Rzepecka and Ryszard Rzepecki
Bamei pigs are special germplasm resources in Qinghai. In the specific environment of the Qinghai plateau, local breeds, through long-term natural and artificial selection, have acquired a relatively stable po...
Authors: Junxia Zhang, Baochun Yang, Xiaocheng Wen and Guoqiang Sun
Mishandling of intracellular chloride (Cl−) concentration ([Cl−]i) in cerebrovascular smooth muscle cells is implicated in several pathological processes, including hyperplasia and remodeling. We investigated the...
Authors: Jingjing Lu, Feng Xu, Yingna Zhang, Hong Lu and Jiewen Zhang
It has been reported that the expression of activating transcription factor 3 (ATF3) is closely associated with both microRNA (miRNA) processing and the progress of many cancers. Our study aimed to explore the...
Authors: Bingxia Shi, Wei Yan, Guolin Liu and Yanjun Guo
Radiotherapy is among the commonly applied treatment options for glioma, which is one of the most common types of primary brain tumor. To evaluate the effect of radiotherapy noninvasively, it is vital for onco...
Authors: Hongxia Li, Yi Cui, Fuyan Li, Wenqi Shi, Wenjing Gao, Xiao Wang and Qingshi Zeng
Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-1α) is an important mediator of the hypoxia response. It regulates the expression of various chemokines involved in tumor growth,...
Authors: Wenming Feng, Tao Xue, Sanxiong Huang, Qilin Shi, Chengwu Tang, Ge Cui, Guanghui Yang, Hui Gong and Huihui Guo
Although significant advances have been made in understanding the mechanisms of macrophage response to Staphylococcus aureus infection, the molecular details are still elusive. Identification of the essential gen...
Patients with anti-β2GPI antibodies display significantly higher platelet activation/aggregation and vascular endothelial cell damage. The mechanism underlying the correlation between platelet activation, vasc...
Authors: Yanfen Zhang, Wenjing Zhang, Caijun Zha and Yanhong Liu
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 ...
MicroRNAs (miRNAs) have physiological and pathophysiological functions that are involved in the regulation of cardiac fibrosis. This study aimed to investigate the effects of miR-495 on high glucose-induced ca...
Authors: Xiaowei Wang, Haiying Jin, Shifeng Jiang and Yanlan Xu
Post-infarction cardiac injury is closely associated with cardiac remodeling and heart dysfunction. Mammalian STE20-like kinase 1 (Mst1), a regulator of cellular apoptosis, is involved in cardiac remodeling in...
Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearl...
Authors: Mokgadi Violet Gwangwa, Anna Margaretha Joubert and Michelle Helen Visagie
Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored...
Authors: Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang and Ming Yang
Lycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP...
Authors: Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li and Huilan Zhu
Epstein–Barr virus (EBV) infection is causatively associated with a variety of human cancers, including gastric cancer (GC), which has one of the highest mortality rates of all human cancers. Long non-coding R...
Authors: Jing Liu, Chunxia Yang, Yufang Gu, Chong Li, Huamei Zhang, Wenfang Zhang, Xueqing Wang, Nan Wu and Chunyan Zheng
The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the i...
Authors: Gabriela Sánchez, Omar Estrada, Giovana Acha, Alfonso Cardozo, Franshelle Peña, Marie Christine Ruiz, Fabián Michelangeli and Claudia Alvarado-Castillo
The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal e...
Authors: Ruijie Gong, Xiaofei Lv and Fengqiong Liu
The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, w...
Authors: Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang and Heng Wu
Arsenic trioxide (As2O3) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2O3 has an antitumo...
Authors: Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai and Kongbin Yang
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is invo...
Authors: Michaela Galoczova, Philip Coates and Borivoj Vojtesek
The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against num...
Authors: Laura Susan Boyd, Devrim Gozuacik and Anna Margaretha Joubert
Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate i...
Authors: Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh and Majd Aljamali
Previous studies indicated that cadmium (Cd) increases PI3-kinase/Akt phosphorylation, resulting in an alteration in GSK-3β activity. However, the mechanism of Cd-induced endoplasmic reticulum (ER) stress in n...
Authors: Seungwoo Kim, Hyosoon Cheon, Sam-Moon Kim and Young-Youl Kim
Platelet-derived growth factor-C (PDGF-C) has been shown to be involved in several biological processes, such as embryonic development, wound healing and angiogenesis, as well as in diseases including tumor fo...
Authors: Tomoaki Kinjo, Chuanhai Sun, Tomomi Ikeda, Takako Ikegami, Yuhki Tada, Tadayuki Akagi, Takashi Yokota and Hiroshi Koide
Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, i...
Authors: Hao Yang, Di Wu, Hua Li, Nan Chen and Yongjun Shang
Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene...
Authors: Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li and Xiaohui Zhang
Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteo...
Authors: Nazli F. Eskici, Sevim Erdem-Ozdamar and Didem Dayangac-Erden
Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. However, the effects of CGRP ...
Authors: Shaohua Wang, Hongxing Dang, Feng Xu, Jian Deng and Xuemei Zheng
Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to...
Authors: Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Shoukath M. Ali, Moghis U. Ahmad and Imran Ahmad
Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects....
Authors: Ying Chen, Lei Zhang, Wen-xin Liu and Ke Wang
Our previous study showed that during in vitro experiments changes in calcium concentration were associated with apoptosis. We presumed that the calcium ion might play a role as intermediate messenger for apop...
Authors: Yanan Li, Yu Yan, Fang Liu, Ming Wang, Fumin Feng and Yonghong Xiao
The transcription factor TWIST1 plays an important role in the epithelial–mesenchymal transition (EMT) process and in the migration, invasion and metastasis of cancer cells. OCT4, which is a homeobox transcrip...
Authors: Mohammad Hossein Izadpanah, Mohammad Reza Abbaszadegan, Yasaman Fahim and Mohammad Mahdi Forghanifard
Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancy. Semaphorin 3F (SEMA3F) is highly conserved but present at a lower level in various cancers than in healthy tissues. While it h...
Authors: Yi Liu, Ronghua Li, Kai Yin, Gang Ren and Yongdong Zhang
The natural dihydroflavonol (+) taxifolin was investigated for its protective effect on Fenton reagent-treated bone marrow-derived mesenchymal stem cells (bmMSCs). Various antioxidant assays were used to deter...
Authors: Xican Li, Hong Xie, Qian Jiang, Gang Wei, Lishan Lin, Changying Li, Xingmei Ou, Lichan Yang, Yulu Xie, Zhen Fu, Yamei Liu and Dongfeng Chen
Several recent studies have demonstrated the great potential of bone marrow cells in regenerative medicine, not only for their ability to differentiate to match a damaged cell type, but also because they synth...
Authors: Yolanda Menéndez-Menéndez, Jesús Otero-Hernández, Jose Antonio Vega, Marcos Pérez-Basterrechea, Silvia Pérez-López, María Álvarez-Viejo and Amaia Ferrero-Gutiérrez
Gliomas are commonly malignant tumors that arise in the human central nervous system and have a low overall five-year survival rate. Previous studies reported that several members of Rab GTPase family are invo...
Authors: Jian Ge, Qianxue Chen, Baohui Liu, Long Wang, Shenqi Zhang and Baowei Ji
The development and integration of bio- and chemocatalytic processes to convert renewable or biomass feedstocks into polymers is a vibrant field of research with enormous potential for environmental protection...
Authors: Aleksandra Marszałek-Harych, Dawid Jędrzkiewicz and Jolanta Ejfler
Prolyl-hydroxyproline (Pro-Hyp) is one of the major constituents of collagen-derived dipeptides. We previously reported that Pro-Hyp promotes the differentiation of osteoblasts by increasing Runx2, osterix and...
Authors: Yoshifumi Kimira, Haruka Odaira, Kaho Nomura, Yuri Taniuchi, Naoki Inoue, Sachie Nakatani, Jun Shimizu, Masahiro Wada and Hiroshi Mano
Many studies have investigated the characteristics and biological activities of type III interferon (IFN), finding that it has similar features to type I IFN but also unique actions because it is recognized by...
The rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the ...
Thoracic aortic dissection (TAD) is one of the most severe aortic diseases. The study aimed to explore the potential role of heat shock protein 27 (HSP27) in the pathogenesis of TAD using an in vitro model of ...
Authors: Sili Zou, Mingfang Liao, Junlin Yang, Tong Huang, Mark Green, Jianjin Wu and Lefeng Qu
Hypoxic conditions induce the expression of hypoxia-inducible factors (HIFs) that allow cells to adapt to the changing conditions and alter the expression of a number of genes including the cystic fibrosis tra...
Authors: Sylwia Bartoszewska, Wojciech Kamysz, Bogdan Jakiela, Marek Sanak, Jarosław Króliczewski, Zsuzsa Bebok, Rafal Bartoszewski and James F. Collawn
TGF-β1 plays an important role in the epithelial–mesenchymal transition (EMT) of epithelial cancers, including non-small cell lung cancer (NSCLC). While the full underlying mechanism remains unclear, miR-9 is ...
Authors: Hui Wang, Qian Wu, Ying Zhang, Hua-Nan Zhang, Yong-Bin Wang and Wei Wang
Our previous study found that single-pass membrane protein with coiled-coil domains 1 (C3orf43; XM_006248472.3) was significantly upregulated in the proliferative phase during liver regeneration. This indicate...
