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  1. This review focuses on DNA–dependent protein kinase (DNA–PK), which is the key regulator of canonical non–homologous end–joining (NHEJ), the predominant mechanism of DNA double–strand break (DSB) repair in mam...

    Authors: Jiangdong Sui, Shichuan Zhang and Benjamin P. C. Chen

    Citation: Cellular & Molecular Biology Letters 2020 25:2

    Content type: Review Letter

    Published on:

  3. Circular RNA (circRNA) has recently been considered as a key regulator in carcinogenesis. In this study, we investigated the functional significance and regulatory role of circ-CAMK2A (hsa_circ_0128332) in lun...

    Authors: Jiahui Du, Guangzhao Zhang, Hongli Qiu, Haifeng Yu and Wuying Yuan

    Citation: Cellular & Molecular Biology Letters 2019 24:72

    Content type: Research

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  4. Sex-determining region Y-box containing gene 30 (SOX30) is a newly identified tumor-associated gene in several types of cancer. However, whether SOX30 is involved in the development and progression of prostate...

    Authors: Qiang Fu, Zhenye Sun, Fan Yang, Tianci Mao, Yanyao Gao and He Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:71

    Content type: Research

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  8. The expression level of miR-376c-3p is significantly lower in infants with neonatal hypoxic-ischemic encephalopathy (HIE) than in healthy infants. However, the biological function of this microRNA remains larg...

    Authors: Heng Zhang, Jie Zhou, Mingxia Zhang, Yanjie Yi and Bing He

    Citation: Cellular & Molecular Biology Letters 2019 24:67

    Content type: Research

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  9. MicroRNAs (miRNAs) function as post-transcriptional gene expression regulators. Some miRNAs, including the recently discovered miR-582–3p, have been implicated in leukemogenesis. This study aimed to reveal the...

    Authors: Haixia Li, Xuefei Tian, Paoqiu Wang, Mao Huang, Ronghua Xu and Tian Nie

    Citation: Cellular & Molecular Biology Letters 2019 24:66

    Content type: Research Letter

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  10. Hypoestrogenism in women is strongly associated with menopause and it can lead to lipid disorder, which predisposes people to premature cardiovascular disease. However, the mechanism of lipid disorder remains ...

    Authors: Ye Meng and Lu Zong

    Citation: Cellular & Molecular Biology Letters 2019 24:65

    Content type: Research Letter

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  11. Hypoxia in the vicinity of bone defects triggers the osteogenic differentiation of precursor cells and promotes healing. The activation of STAT3 signaling in mesenchymal stem cells (MSCs) has similarly been re...

    Authors: Xin Yu, Qilong Wan, Xiaoling Ye, Yuet Cheng, Janak L. Pathak and Zubing Li

    Citation: Cellular & Molecular Biology Letters 2019 24:64

    Content type: Research

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  12. The participation of long noncoding RNAs (lncRNAs) in myocardial infarction has recently been noted. However, their underlying roles in the border zone of myocardial infarction remain unclear. This study uses ...

    Authors: Qingkun Meng, Zhijun Sun, Hui Gu, Jiaying Luo, Jingjing Wang, Chuanhe Wang and Su Han

    Citation: Cellular & Molecular Biology Letters 2019 24:63

    Content type: Research Letter

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  13. Myocardial ischaemia reperfusion injury (MIRI) is a difficult problem in clinical practice, and it may involve various microRNAs. This study investigated the role that endogenous microRNA-146a plays in myocard...

    Authors: Tiantian Zhang, Yiwen Ma, Lin Gao, Chengyu Mao, Huasu Zeng, Xiaofei Wang, Yapin Sun, Jianmin Gu, Yue Wang, Kan Chen, Zhihua Han, Yuqi Fan, Jun Gu, Junfeng Zhang and Changqian Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:62

    Content type: Research

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  16. Breast tumor growth and recurrence are driven by an infrequent population of breast tumor-initiating cells (BTIC). We and others have reported that the frequency of BTIC is orders of magnitude higher when brea...

    Authors: William D. Gwynne, Mirza S. Shakeel, Jianhan Wu, Robin M. Hallett, Adele Girgis-Gabardo, Anna Dvorkin-Gheva and John A. Hassell

    Citation: Cellular & Molecular Biology Letters 2019 24:59

    Content type: Research Letter

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  17. Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. P21-activated kinase 4 (PAK4) and miR-9-5p have emerged as attractive therapeutic targets in several tumor types, but in CRC, the r...

    Authors: Meihua Wang, Qianqian Gao, Yufang Chen, Ziyan Li, Lingping Yue and Yun Cao

    Citation: Cellular & Molecular Biology Letters 2019 24:58

    Content type: Research Letter

    Published on:

  18. Glucose-regulated protein 78 (GRP78) is a member of the HSP70 protein family and a key endoplasmic reticulum chaperone. It has been revealed to play important roles both in the maturation, folding and transpor...

    Authors: Ying Liu, Xuemei Wang, Zhen Zhen, Yanbo Yu, Youwen Qiu and Wensheng Xiang

    Citation: Cellular & Molecular Biology Letters 2019 24:57

    Content type: Research Letter

    Published on:

  20. Hypoxia, a major condition associated with the tumor microenvironment, stimulates the migration of cancer cells. SOX2 is a powerful transcription factor that shows higher expression in several cancers, however...

    Authors: Yueyuan Wang, Maria Bibi, Pengxiang Min, Wenjie Deng, Yujie Zhang and Jun Du

    Citation: Cellular & Molecular Biology Letters 2019 24:55

    Content type: Research

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  21. Ectodermal dysplasias are characterized by developmental abnormalities in ectodermal structures. Hypohidrotic ectodermal dysplasias (HED) are the most common subtype. They are most commonly inherited via X-lin...

    Authors: Marzieh Rahbaran, Maryam Hassani Doabsari, Simindokht Salavitabar, Neda Mokhberian, Ziba Morovvati and Saeid Morovvati

    Citation: Cellular & Molecular Biology Letters 2019 24:54

    Content type: Research Letter

    Published on:

  22. Gastric cancer is a malignant tumor with the fifth incidence and third mortality worldwide. There were 951,000 new cases and about 723,000 patients died of it in 2012. Undoubtedly, gastric cancer has been affe...

    Authors: Fei Jiang and Xiaobing Shen

    Citation: Cellular & Molecular Biology Letters 2019 24:53

    Content type: Review

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  23. Hepatic stellate cell (HSC) activation is a central event during hepatic fibrosis. Aerobic glycolysis is one of its metabolic hallmarks. Blocking glycolysis is a novel therapeutic option for liver fibrosis. Th...

    Authors: Dujing Ban, Shangbo Hua, Wen Zhang, Chao Shen, Xuehua Miao and Wensheng Liu

    Citation: Cellular & Molecular Biology Letters 2019 24:52

    Content type: Research Letter

    Published on:

  24. MicroRNAs (miRNAs or miRs) serve crucial roles in the progression of osteoporosis. This study investigated the role and specific molecular mechanism of miR-135-5p in regulating osteoblast differentiation and c...

    Authors: Nuo Yin, Longzhang Zhu, Liang Ding, Junjie Yuan, Li Du, Mingmang Pan, Feng Xue and Haijun Xiao

    Citation: Cellular & Molecular Biology Letters 2019 24:51

    Content type: Research

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  25. Long non-coding RNA Malat1 has been widely identified as an oncogene which shows a significant relationship with tumorigenesis in colorectal cancer (CRC). Nonetheless, whether Malat1 participates in the autoph...

    Authors: Yaoran Si, Zhaoguo Yang, Quanxing Ge, Lingbing Yu, Meiying Yao, Xinfang Sun, Zheng Ren and Chunsheng Ding

    Citation: Cellular & Molecular Biology Letters 2019 24:50

    Content type: Research

    Published on:

  26. Synuclein-γ has been demonstrated to be highly expressed in various human cancers including cervical cancer, and has been shown to play a critical role in tumor aggressiveness. We aimed to investigate the role of...

    Authors: Chunnian Zhang, Liqin Gu, Xiafang Li and Jianzhong Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:49

    Content type: Research Letter

    Published on:

  27. In recent years, microRNA-211 (miR211) has been considered as a tumor suppressor in multiple malignancies. However, the function of miR211 in human osteosarcoma has not been explored intensively so far. In thi...

    Authors: Yihua Pei, Qin Yao, Yingchao Li, Xin Zhang and Bozhen Xie

    Citation: Cellular & Molecular Biology Letters 2019 24:48

    Content type: Research Letter

    Published on:

  28. Chemotherapy based on paclitaxel (PTX) is the standard treatment for a range of cancers, including triple-negative breast cancer (TNBC), but the increasing development of resistance has reduced/has negatively ...

    Authors: Mei Liu, Can Gong, Renyuan Xu, Yu Chen and Xiaodong Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:47

    Content type: Research

    Published on:

  30. The study aimed to investigate the effect of oxidative stress on Prestin expression, and explore the transcription factors (TFs) that are involved in regulating the expression of Prestin in House Ear Institute-Or...

    Authors: Xuan Luo, Yun Xia, Xu-Dong Li and Jun-Yi Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:45

    Content type: Research

    Published on:

  31. Deer antler is the only mammalian organ that can be completely regenerated every year. Its periodic regeneration is regulated by multiple factors, including transforming growth factor β (TGF-β). This widely di...

    Authors: Mingxiao Liu, Xiangyu Han, Hongyun Liu, Danyang Chen, Yue Li and Wei Hu

    Citation: Cellular & Molecular Biology Letters 2019 24:44

    Content type: Research Letter

    Published on:

  32. Impairment of the blood–brain barrier (BBB) could result in secondary cerebral edema and life-threatening pancreatic encephalopathy in patients with severe acute pancreatitis (SAP). Mesenchymal stem cells (MSC...

    Authors: Ronggui Lin, Ming Li, Meiqin Luo, Tianhong Teng, Yu Pan and Heguang Huang

    Citation: Cellular & Molecular Biology Letters 2019 24:43

    Content type: Research

    Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2019 24:56

  33. Human bronchial epithelium (HBE)-Dp71 anti-sense(AS)cells with stably transfected Dp71 siRNA plasmids were prepared for further exploration of Dp71 biological traits in cells other than PC12. HBE-Dp71AS cells ...

    Authors: Sichuang Tan, Shuai Zhao, Xuefei Xiao, Lan Xiao, Jinliang Xie and Sipin Tan

    Citation: Cellular & Molecular Biology Letters 2019 24:42

    Content type: Research

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  35. Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in...

    Authors: Linyan Zhu and Liqun Chen

    Citation: Cellular & Molecular Biology Letters 2019 24:40

    Content type: Review Letter

    Published on:

  36. The aim of this study was to investigate the effect of human umbilical vein endothelial cells on epithelial-to-mesenchymal transition of the cervical cancer cell line SiHa by studying the Notch1/lysyl oxidase ...

    Authors: Jinghua Ou, Defeng Guan and Yongxiu Yang

    Citation: Cellular & Molecular Biology Letters 2019 24:39

    Content type: Research Letter

    Published on:

  37. Exploration of the genes with abnormal expression during the development of breast cancer is essential to provide a deeper understanding of the mechanisms involved. Transcriptome sequencing and bioinformatics ...

    Authors: Yulong Bao, Li Wang, Lin Shi, Fen Yun, Xia Liu, Yongxia Chen, Chen Chen, Yanni Ren and Yongfeng Jia

    Citation: Cellular & Molecular Biology Letters 2019 24:38

    Content type: Research

    Published on:

  38. Accumulating evidence has shown that altered microRNA (miR) modulation is implicated in the pathologies of ischemic stroke. However, it is unclear whether and how hsa-miR-19a-3p mediates cerebral ischemic inju...

    Authors: Xiao-Li Ge, Jin-Li Wang, Xin Liu, Jia Zhang, Chang Liu and Li Guo

    Citation: Cellular & Molecular Biology Letters 2019 24:37

    Content type: Research

    Published on:

  39. Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation, induction of apoptosis, and inhibition of energy me...

    Authors: Zhihua Ren, Hongyi He, Zhicai Zuo, Zhiwen Xu, Zhanyong Wei and Junliang Deng

    Citation: Cellular & Molecular Biology Letters 2019 24:36

    Content type: Review

    Published on:

  40. Pulmonary edema is one of the pathological characteristics of acute respiratory distress syndrome (ARDS). The epithelial sodium channel (ENaC) is thought to be the rate-limiting factor for alveolar fluid clear...

    Authors: Jing He, Di Qi, Xu-mao Tang, Wang Deng, Xin-yu Deng, Yan Zhao and Dao-xin Wang

    Citation: Cellular & Molecular Biology Letters 2019 24:35

    Content type: Short report

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  42. Induction of lysosomal function and autophagy is regarded as an adaptive mechanism in response to cellular stress. The transcription factor EB (TFEB) has been identified as a master regulator of lysosomal func...

    Authors: Hsuan-Yeh Pan, Abdulla H. Alamri and Mallika Valapala

    Citation: Cellular & Molecular Biology Letters 2019 24:33

    Content type: Short report

    Published on:

  43. Peritoneal fibrosis remains a serious complication of long-term peritoneal dialysis (PD) leading to peritoneal membrane ultrafiltration failure. Epithelial–mesenchymal transition (EMT) of peritoneal mesothelia...

    Authors: Jun-Li Zhao, Mei-Zi Guo, Jun-Jun Zhu, Ting Zhang and Dan-Yan Min

    Citation: Cellular & Molecular Biology Letters 2019 24:32

    Content type: Research Letter

    Published on:

  45. Gemcitabine (2′,2′-difluoro-2′-deoxycytidine;dFdC) is a first-line chemotherapy drug for pancreatic cancer. Recently, a synergistic anti-tumor treatment of dFdC and hyperthermia has achieved good clinical resu...

    Authors: HB Jin, L Lu, L Xie, JF Yang, XF Zhang and SL Ma

    Citation: Cellular & Molecular Biology Letters 2019 24:30

    Content type: Short report

    Published on:

  46. In its RING domain, tumor necrosis factor receptor-associated factor 6 (TRAF6) has ubiquitin E3 ligase activity that facilitates the formation of lysine 63-linked polyubiquitin chains. This activity is require...

    Authors: Hyun-Duk Jang, Hye Zin Hwang, Hyo-Soo Kim and Soo Young Lee

    Citation: Cellular & Molecular Biology Letters 2019 24:29

    Content type: Research Letter

    Published on:

  47. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor with a pivotal role in physiological and pathological responses to hypoxia. While HIF-1α is known to be involved in hypoxia-induced upregulation o...

    Authors: Yuree Byun, Young-Chul Choi, Yunhui Jeong, Gangtae Lee, Sena Yoon, Yongsu Jeong, Jaeseung Yoon and Kwanghee Baek

    Citation: Cellular & Molecular Biology Letters 2019 24:28

    Content type: Short report

    Published on:

  48. This study aimed to investigate the effects of miR-613 on the proliferation, invasion and apoptosis of rheumatoid arthritis synovial fibroblasts (RASFs).

    Authors: Liang Liu, Yanhua Zuo, Yan Xu, Zongfang Zhang, Ying Li and Jie Pang

    Citation: Cellular & Molecular Biology Letters 2019 24:8

    Content type: Research

    Published on:

  50. Given the high mortality rate and unclear pathogenesis for liver cancer, investigation of its molecular mechanisms is essential. We focused on the long non-coding RNA (lncRNA) MIR4435-2HG, which was recently r...

    Authors: Qinglei Kong, Caiqian Liang, Yi Jin, Yuhang Pan, Dayue Tong, Qingcong Kong and Jing Zhou

    Citation: Cellular & Molecular Biology Letters 2019 24:26

    Content type: Research Letter

    Published on:

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Cellular & Molecular Biology Letters

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