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Cellular & Molecular Biology Letters was founded in 1996 and transferred to BioMed Central in 2016. Previously, its publishers were Walter De Gruyter in 2015 (content available from De Gruyter's archive), and Springer from 2006–2014 (content available from BMC web page). Articles published between 1996 and 2005 can be found at, CMBL home page, the Volume List tab. To request free electronic versions of these articles, please contact

Thematic Series

Invited Papers

The papers in this collection were specially invited by the editors and represent work by leading researchers in their fields, as well the authors of the most cited papers from the previous issues of our journal (CMBL).

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  1. Short report

    The novel protein C3orf43 accelerates hepatocyte proliferation

    Our previous study found that single-pass membrane protein with coiled-coil domains 1 (C3orf43; XM_006248472.3) was significantly upregulated in the proliferative phase during liver regeneration. This indicate...

    Chunyan Zhang, Cuifang Chang, Deming Li, Fuchun Zhang and Cunshuan Xu

    Cellular & Molecular Biology Letters 2017 22:21

    Published on: 16 September 2017

  2. Mini review

    Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?

    Clinicians use clinical and pathological parameters, such as tumour size, grade and nodal status, to make decisions on adjuvant treatments for breast cancer. However, therapeutic decisions based on these featu...

    Umar Wazir, Kinan Mokbel, Amtul Carmichael and Kefah Mokbel

    Cellular & Molecular Biology Letters 2017 22:20

    Published on: 4 September 2017

  3. Research

    Luteolin, quercetin, genistein and quercetagetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in H9c2 cardiomyoblasts

    One of the microorganisms from dental plaque associated with severe inflammatory responses in infectious endocarditis is Porphyromonas gingivalis. It is a Gram-negative bacteria harvested from chronic periodontit...

    Gloria Gutiérrez-Venegas, Alfredo Torras-Ceballos, Juan Arturo Gómez-Mora and Berenice Fernández-Rojas

    Cellular & Molecular Biology Letters 2017 22:19

    Published on: 4 September 2017

  4. Review

    Gene functioning and storage within a folded genome

    In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly of DNA-protein complex, ch...

    Sergey V. Razin and Sergey V. Ulianov

    Cellular & Molecular Biology Letters 2017 22:18

    Published on: 29 August 2017

  5. Short report

    PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2

    Retinoblastoma (RB), a childhood cancer, is caused by biallelic mutation of the RB1 gene, but its development is not clearly understood. Furthermore, the presence of a cancer stem cell subpopulation in RB might i...

    Suganya Sivagurunathan, Jayamuruga Pandian Arunachalam and Subbulakshmi Chidambaram

    Cellular & Molecular Biology Letters 2017 22:17

    Published on: 29 August 2017

  6. Research

    ADAM23 promotes neuronal differentiation of human neural progenitor cells

    ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation.

    Annett Markus-Koch, Oliver Schmitt, Susanne Seemann, Jan Lukas, Dirk Koczan, Mathias Ernst, Georg Fuellen, Andreas Wree, Arndt Rolfs and Jiankai Luo

    Cellular & Molecular Biology Letters 2017 22:16

    Published on: 18 August 2017

  7. Research

    SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

    Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs ...

    Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong and Zhaochen Shan

    Cellular & Molecular Biology Letters 2017 22:14

    Published on: 8 August 2017

  8. Research

    Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades

    FFA1 is abundantly expressed in the liver, skeletal muscle, monocytes and nervous system, but is particularly abundant in pancreatic β cells. It is widely believed that FFA1 exerts its regulatory roles in a va...

    Jing Qian, Yuyang Gu, Chun Wu, Feng Yu, Yuqi Chen, Jingmei Zhu, Xingyi Yao, Chen Bei and Qingqing Zhu

    Cellular & Molecular Biology Letters 2017 22:13

    Published on: 21 July 2017

  9. Review

    Cells of human breast milk

    Human milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to proteins, lipids, carbohydrates and other biologically active components, breast milk contain...

    Malgorzata Witkowska-Zimny and Ewa Kaminska-El-Hassan

    Cellular & Molecular Biology Letters 2017 22:11

    Published on: 13 July 2017

  10. Review

    Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma

    Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggr...

    Zakir Khan, Abdul Arif Khan, Hariom Yadav, Godavarthi B. K. S. Prasad and Prakash Singh Bisen

    Cellular & Molecular Biology Letters 2017 22:8

    Published on: 5 April 2017

  11. Short Report

    ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype

    Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists. It is caused by inactivating mutat...

    Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino and Faustino Bisaccia

    Cellular & Molecular Biology Letters 2017 22:7

    Published on: 4 April 2017

  12. Research

    A simple and effective protocol for fast isolation of human Tenon’s fibroblasts from a single trabeculectomy biopsy – a comparison of cell behaviour in different culture media

    Human Tenon’s fibroblasts (HTFs) play a crucial role in wound healing. They cause postoperative scarring of the filtering bleb and are thus responsible for trabeculectomy failure. This study aimed to find an e...

    Agata Przekora, Tomasz Zarnowski and Grazyna Ginalska

    Cellular & Molecular Biology Letters 2017 22:5

    Published on: 9 March 2017

  13. Mini review

    The regulatory mechanisms of NG2/CSPG4 expression

    Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), is a surface type I transmembrane core proteoglycan that is crucially involved in cell survival, migration and angiogene...

    Emmanuel Ampofo, Beate M. Schmitt, Michael D. Menger and Matthias W. Laschke

    Cellular & Molecular Biology Letters 2017 22:4

    Published on: 28 February 2017

  14. Research

    Avoiding the side effects of electric current pulse application to electroporated cells in disposable small volume cuvettes assures good cell survival

    The harmful side effects of electroporation to cells due to local changes in pH, the appearance of toxic electrode products, temperature increase, and the heterogeneity of the electric field acting on cells in...

    Maciej Grys, Zbigniew Madeja and Włodzimierz Korohoda

    Cellular & Molecular Biology Letters 2017 22:1

    Published on: 13 January 2017

  15. Mini review

    p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

    The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body...

    Wei Jing Liu, Lin Ye, Wei Fang Huang, Lin Jie Guo, Zi Gan Xu, Hong Luan Wu, Chen Yang and Hua Feng Liu

    Cellular & Molecular Biology Letters 2016 21:29

    Published on: 13 December 2016

  16. Review

    Framework to function: mechanosensitive regulators of gene transcription

    Mechanobiology has shifted our understanding of fundamental cellular and physiological functions. Changes to the stiffness of the extracellular matrix, cell rigidity, or shape of the cell environment were cons...

    Megan Finch-Edmondson and Marius Sudol

    Cellular & Molecular Biology Letters 2016 21:28

    Published on: 7 December 2016

  17. Short report

    IgG silencing induces apoptosis and suppresses proliferation, migration and invasion in LNCaP prostate cancer cells

    Immunoglobulin G (IgG) has been implicated in the progression of various cancers. This study explored the role of IgG in the proliferation, apoptosis, cell cycle and in vitro invasive properties of LNCaP prost...

    Yawen Xu, Binshen Chen, Shaobo Zheng, Yong Wen, Abai Xu, Kai Xu, Bingkun Li and Chunxiao Liu

    Cellular & Molecular Biology Letters 2016 21:27

    Published on: 3 December 2016

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