Articles

Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma

Glycosyltransferases play a crucial role in various cancers. β1, 3-N-acetylglucosaminyltransferase 2, a polylactosamine synthase, is an important member of the glycosyltransferase family. However, the biological ...

Authors: Zhiguo Luo, Qing Hu, Yuanhui Tang, Yahui Leng, Tian Tian, Shuangyue Tian, Chengyang Huang, Ao Liu, Xinzhou Deng and Li Shen

The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation

Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signal...

Authors: Hongjuan You, Qi Li, Delong Kong, Xiangye Liu, Fanyun Kong, Kuiyang Zheng and Renxian Tang

The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate. The majority of deaths in this disease are caused...

Authors: Mohammad Rafi Khezri, Reza Varzandeh and Morteza Ghasemnejad-Berenji

LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis

Osteosarcoma (OS) is a common primary bone malignancy. Long noncoding RNA HCG18 is known to play an important role in a variety of cancers. However, its role in OS and relevant molecular mechanisms are unclear.

Authors: Xiaohui Pan, Jin Guo, Canjun Liu, Zhanpeng Pan, Zhicheng Yang, Xiang Yao and Jishan Yuan

Specificity of H₂O₂ signaling in leaf senescence: is the ratio of H₂O₂ contents in different cellular compartments sensed in Arabidopsis plants?

Leaf senescence is an integral part of plant development and is driven by endogenous cues such as leaf or plant age. Developmental senescence aims to maximize the usage of carbon, nitrogen and mineral resource...

Authors: Ulrike Zentgraf, Ana Gabriela Andrade-Galan and Stefan Bieker

Mitochondrial potassium channels: A novel calcitriol target

Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). However, VDR-mediated transcriptional modulation does n...

Authors: Anna M. Olszewska, Adam K. Sieradzan, Piotr Bednarczyk, Adam Szewczyk and Michał A. Żmijewski

The functions and roles of sestrins in regulating human diseases

Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect organisms against various noxious stimuli including DNA damage, oxidative stress, starvation, endoplasmic reticulum ...

Authors: Yitong Chen, Tingben Huang, Zhou Yu, Qiong Yu, Ying Wang, Ji’an Hu, Jiejun Shi and Guoli Yang

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading to failure of treatment and recurrence of the disease. ...

Authors: Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi and Bahman Yousefi

Correction to: Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Authors: Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang and Lining Wei

MicroRNA-148a-3p suppresses cell proliferation and migration of esophageal carcinoma by targeting CEP55

This study evaluated microRNA-148a-3p in esophageal carcinoma cells. The prediction of bioinformatics analysis revealed that microRNA-148a-3p may target CEP55. qRT-PCR and western blot showed that CEP55 level ...

Authors: Yong Lin, Yushan Chen, Rongqiang Shen, Dingzhu Chen and Yimin Lin

Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?

Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the p53-binding domain of MDM2...

Authors: Lucia Haronikova, Ondrej Bonczek, Pavlina Zatloukalova, Filip Kokas-Zavadil, Martina Kucerikova, Philip J. Coates, Robin Fahraeus and Borivoj Vojtesek

MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer

The study was designed to elucidate the association and functional roles of miR-26b-5p and c-MYC binding protein (MYCBP) in triple-negative breast cancer (TNBC).

Authors: Sugang Ma, Hui Wei, Chunyan Wang, Jixia Han, Xiumin Chen and Yang Li

Amelioration of human peritoneal mesothelial cell co-culture-evoked malignant potential of ovarian cancer cells by acacetin involves LPA release-activated RAGE-PI3K/AKT signaling

Ovarian cancer is a devastating gynecological malignancy and frequently presents as an advanced carcinoma with disseminated peritoneum metastasis. Acacetin exerts anti-cancerous effects in several carcinomas. ...

Authors: Meng Tian, Yingjie Tang, Ting Huang, Yang Liu and Yingzheng Pan

Esterase D stabilizes FKBP25 to suppress mTORC1

Esterase D (ESD) is a nonspecific esterase that detoxifies formaldehyde. Many reports have stated that ESD activity is associated with a variety of physiological and pathological processes. However, the detail...

Authors: Yuejun Yang, Xinpeng Chen, Wen Yao, Xiaoling Cui, Na Li, ZhaoMin Lin, Baoxiang Zhao and Junying Miao

LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway

Hepatocellular carcinoma (HCC) is now the second leading cause of cancer death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and metastasis. The aim of this study was to invest...

Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang and Hongyi Zhang

TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2

Intestinal mucositis is a common side effect of chemotherapy and radiotherapy. Very few drugs can efficiently ameliorate it. Tertiary butylhydroquinone (TBHQ) is a widely used food preservative with known immu...

Authors: Shihua Deng, Dongming Wu, Li Li, Jin Li and Ying Xu

Advances in the application of mesenchymal stem cells, exosomes, biomimetic materials, and 3D printing in osteoporosis treatment

Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a majo...

Authors: Xiao-Yu He, Hai-Ming Yu, Shu Lin and Yi-Zhong Li

Laboratory methods to decipher epigenetic signatures: a comparative review

Epigenetics refers to nucleotide sequence-independent events, and heritable changes, including DNA methylation and histone modification (as the two main processes), contributing to the phenotypic features of t...

Authors: Raheleh Halabian, Valizadeh Arshad, Ali Ahmadi, Pardis Saeedi, Sadegh Azimzadeh Jamalkandi and Mohammad Reza Alivand

The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression

Liquid–liquid phase separation (LLPS) within the nucleus is directly linked to driving gene expression through transcriptional complexes. Histone lysine methyltransferase 2D (KMT2D) is widely present in many c...

Authors: Weihan Li, Lei Wu, Hui Jia, Zenghua Lin, Renhao Zhong, Yukun Li, Chenwei Jiang, Shifan Liu, Xiaorong Zhou and Erhao Zhang

Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management. Surprisingly, the effect o...

Authors: Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik and Krzysztof Książek

Targeting microRNAs with thymoquinone: a new approach for cancer therapy

Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy a...

Authors: Mina Homayoonfal, Zatollah Asemi and Bahman Yousefi

Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases

Keratinocytes and fibroblasts represent the major cell types in the epidermis and dermis of the skin and play a significant role in maintenance of skin homeostasis. However, the biological characteristics of k...

Authors: Tiancheng Wang, Zhenwei Zhou, Enjing Luo, Jinghong Zhong, Daqing Zhao, Haisi Dong and Baojin Yao

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

More powerful prognostic and diagnostic tools are urgently needed for identifying and treating ovarian cancer (OC), which is the most fatal malignancy in women in developed countries. Circular RNAs (circRNAs) ...

Authors: Zahra Foruzandeh, Fatemeh Zeinali-Sehrig, Kazem Nejati, Dara Rahmanpour, Fariba Pashazadeh, Farhad Seif and Mohammad Reza Alivand

HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia r...

Authors: Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang, Weiheng Wen, Weiqiang Jiang, Hong Chen, Donghui Liang, Jia Sun and Ming Wang

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

Resistance against conventional chemotherapeutic agents is one of the main reasons for tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are associated with drug resistance, inclu...

Authors: Ghazaleh Khalili-Tanha and Meysam Moghbeli

Direct differentiation of tonsillar biopsy-derived stem cells to the neuronal lineage

Neurological disorders are considered one of the greatest burdens to global public health and a leading cause of death. Stem cell therapies hold great promise for the cure of neurological disorders, as stem ce...

Authors: Michal Arad, Robert A. Brown, Raju Khatri, Rodney J. Taylor and Michal Zalzman

Apoptosis-promoting properties of miR-3074-5p in MC3T3-E1 cells under iron overload conditions

Iron overload can promote the development of osteoporosis by inducing apoptosis in osteoblasts. However, the mechanism by which miRNAs regulate apoptosis in osteoblasts under iron overload has not been elucida...

Authors: Yi Feng, Pei-Yan He, Wei-Dong Kong, Wan-Jing Cen, Peng-Lin Wang, Chang Liu, Wu Zhang, Shu-Shu Li and Jian-Wei Jiang

Serum exosomal pregnancy zone protein as a promising biomarker in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a kind of intestinal immune dysfunction disease, and its occurrence and prevalence are on the rise worldwide. As a chronic gastrointestinal disease, its pathogenesis is stil...

Authors: Jing Shao, Yan Jin, Chunhong Shao, Hui Fan, Xiaorui Wang and Guang Yang

β-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-β/Smad3 signaling

Alkannin-based pharmaceutical formulations for improving wound healing have been on the market for several years. However, detailed molecular mechanisms of their action have yet to be elucidated. Here, we i...

Authors: Xiao Yang, Weijing Fan, Renyan Huang and Guobin Liu

Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formation

Burn injury is one of the potential causes of heterotopic ossification (HO), which is a rare but debilitating condition. The incidence ranges from 3.5 to 5.6 depending on body area. Burns that cover a larger p...

Authors: Xianglin Hu, Zhengwang Sun, Fengfeng Li, Chaoyin Jiang, Wangjun Yan and Yangbai Sun

LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis

Long noncoding RNA (lncRNA), urothelial carcinoma-associated 1 (UCA1) is aberrantly expressed in multiple cancers and has been verified as an oncogene. However, the underlying mechanism of UCA1 in the developm...

Authors: An Yang, Xin Liu, Ping Liu, Yunzhang Feng, Hongbo Liu, Shen Gao, Limin Huo, Xinyan Han, Jurong Wang and Wei Kong

Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease

In the past decade, G protein-coupled receptors have emerged as drug targets, and their physiological and pathological effects have been extensively studied. Among these receptors, GPR119 is expressed in multi...

Authors: Jianan Zhao, Yu Zhao, Yiyang Hu and Jinghua Peng

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer mic...

Authors: Meng Li, Di Zhong and Guozhong Li

Macrophage polarization by MSC-derived CXCL12 determines tumor growth

Phenotypic and functional heterogeneity of macrophages is known to be the main reason for their ability to regulate inflammation and promote tumorigenesis. Mesenchymal stem cells (MSCs) are one of the principa...

Authors: Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah and Mohamad Zamani-Ahmadmahmudi

Autophagy receptors as viral targets

Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles...

Authors: Päivi Ylä-Anttila

β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275

We have previously found that β-elemene could inhibit the viability of airway granulation fibroblasts and prevent airway hyperplastic stenosis. This study aimed to elucidate the underlying mechanism and protec...

Authors: Guoying Zhang, Cheng Xue and Yiming Zeng

LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis

Although lncRNA TP73-AS1 has been shown to play important roles in various human diseases, its function in atherosclerosis (AS) remains unclear.

Authors: Jia Ni, Zhen Huang and Dan Wang

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription fact...

Authors: Dazhi Fu, Chunxiao Wang, Lei Yu and Rui Yu

Circular RNA expression profile in transgenic diabetic mouse kidneys

Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNA...

Authors: Xuan Xiong, Changchun Liu, Meiren Shen, Qian Yang, Qiang Zhao, Xiaoyan Li, Xiaoshi Zhong and Zhiwei Wang

Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A

The suppressive effects of miR-33a-5p have been reported in colorectal cancer and lung cancer. However, the functional role of miR-33a-5p in pancreatic ductal adenocarcinoma (PDAC) has not yet been elucidated.

Authors: Yanfen Lian, Dongxiao Jiang and Jiangtao Sun

Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells

Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This stu...

Authors: Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo and Jin Wang

LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions

Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differ...

Authors: Xiaozhong Zhou, Wangyang Xu, Yeyang Wang, Hui Zhang, Li Zhang, Chao Li, Shun Yao, Zixiang Huang, Lishan Huang and Dixin Luo

miR-29a sensitizes the response of glioma cells to temozolomide by modulating the P53/MDM2 feedback loop

Recently, pivotal functions of miRNAs in regulating common tumorigenic processes and manipulating signaling pathways in brain tumors have been recognized; notably, miR‐29a is closely associated with p53 signal...

Authors: Qiudan Chen, Weifeng Wang, Shuying Chen, Xiaotong Chen and Yong Lin

MiR-501 promotes tumor proliferation and metastasis by targeting HOXD10 in endometrial cancer

Several studies have shown the crucial role of miR-501 in regulating cellular pathology in various cancers. However, the function and expression of miR-501 in endometrial cancer (EC) remain obscure.

Authors: Xiaomei Sun, Lingtong Hou, Chunping Qiu and Beihua Kong

Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1α

Some natural compounds inhibit cancer cell growth in various cancer cell lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological effects and mechanisms of worenine (is...

Authors: Lijiang Ji, Weixing Shen, Feng Zhang, Jie Qian, Jie Jiang, Liping Weng, Jiani Tan, Liu Li, Yugen Chen, Haibo Cheng and Dongdong Sun

mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types

Mammalian/mechanistic target of rapamycin (mTOR) complexes are essential for cell proliferation, growth, differentiation, and survival. mTORC1 hyperactivation occurs in the tuberous sclerosis complex (TSC). mT...

Authors: Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska and Jacek Jaworski

Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

Most currently recommended therapies for metabolic dysfunction-associated fatty liver disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and compiled the most recent research into po...

Authors: Jianan Zhao, Yiyang Hu and Jinghua Peng

Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation

In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas G...

Authors: Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan and Hiroaki Konishi

Actin polymerization state regulates osteogenic differentiation in human adipose-derived stem cells

Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintenance of cell shape, and material transport.

Authors: Bing Sun, Rongmei Qu, Tingyu Fan, Yuchao Yang, Xin Jiang, Asmat Ullah Khan, Zhitao Zhou, Jingliao Zhang, Kuanhai Wei, Jun Ouyang and Jingxing Dai

Association of cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene expression and rs2383207 variant with breast cancer risk and survival

The expression signature of deregulated long non-coding RNAs (lncRNAs) and related genetic variants is implicated in every stage of tumorigenesis, progression, and recurrence. This study aimed to explore the a...

Authors: Shahad W. Kattan, Yahya H. Hobani, Sameerah Shaheen, Sara H. Mokhtar, Mohammad H. Hussein, Eman A. Toraih, Manal S. Fawzy and Hussein Abdelaziz Abdalla