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  1. Kidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelial cell injury and death, leading to acute kidney injury and the transformation of acute...

    Authors: Yihang Yu, Meiling Chen, Qitong Guo, Lianju Shen, Xing Liu, Jianbo Pan, Yuanyuan Zhang, Tao Xu, Deying Zhang and Guanghui Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:12
    Content type: Research Published on:

  2. Glyphosate (GLY), as the active ingredient of the most widely used herbicide worldwide, is commonly detected in the environment and living organisms, including humans. Its toxicity and carcinogenicity in mamma...

    Authors: Jiangpeng Wu, Xiuping Sun, Chunyi Wu, Xiaoping Hong, Lulin Xie, Zixu Shi, Liang Zhao, Qingfeng Du, Wei Xiao, Jichao Sun and Jigang Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:11
    Content type: Research Letter Published on:

  3. TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 ...

    Authors: Asfia Soomro, Mohammad Khajehei, Renzhong Li, Kian O’Neil, Dan Zhang, Bo Gao, Melissa MacDonald, Masao Kakoki and Joan C. Krepinsky
    Citation: Cellular & Molecular Biology Letters 2023 28:10
    Content type: Research Published on:

  4. Bone marrow-derived mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs) have shown potent anti-inflammatory function in various pathological conditions, such as osteoarthritis and neurodegenera...

    Authors: Xueke Li, Yi Zhong, Wuqi Zhou, Yishu Song, Wenqu Li, Qiaofeng Jin, Tang Gao, Li Zhang and Mingxing Xie
    Citation: Cellular & Molecular Biology Letters 2023 28:9
    Content type: Research Letter Published on:

  5. Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hypothesis contrasts insufficient experimental evidence. The q...

    Authors: Caroline Diener, Martin Hart, Claudia Fecher-Trost, Jessica Knittel, Stefanie Rheinheimer, Markus R. Meyer, Jens Mayer, Veit Flockerzi, Andreas Keller and Eckart Meese
    Citation: Cellular & Molecular Biology Letters 2023 28:8
    Content type: Research Letter Published on:

  6. Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemical signals and thereby trigger osteogenic programs necessary for alveolar bone remodeli...

    Authors: Jixiao Wang, Huiqi Yang, Xiaobei Ma, Jiani Liu, Lan Li, Lei Chen and Fulan Wei
    Citation: Cellular & Molecular Biology Letters 2023 28:7
    Content type: Research Published on:

  7. Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumors in adults. Despite significant breakthroughs in standard treatment, only about 5% of ...

    Authors: Hamed Hosseinalizadeh, Omid Mohamadzadeh, Mohammad Saeed Kahrizi, Zahra Razaghi Bahabadi, Daniel J. Klionsky and Hamed Mirzei
    Citation: Cellular & Molecular Biology Letters 2023 28:6
    Content type: Review Letter Published on:

  8. Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects the recovery of motor function. Bone-marrow-derived macrophages (BMDMs) were recruited t...

    Authors: Cheng Ju, Yangguang Ma, Xiaoshuang Zuo, Xuankang Wang, Zhiwen Song, Zhihao Zhang, Zhijie Zhu, Xin Li, Zhuowen Liang, Tan Ding, Xueyu Hu and Zhe Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:5
    Content type: Research Published on:

  9. Ischemia–reperfusion injury (IRI) is an inevitable process in renal transplantation that significantly increases the risk of delayed graft function, acute rejection, and even graft loss. Formyl peptide recepto...

    Authors: Yirui Cao, Juntao Chen, Feng Liu, Guisheng Qi, Yufeng Zhao, Shihao Xu, Jiyan Wang, Tongyu Zhu, Yi Zhang and Yichen Jia
    Citation: Cellular & Molecular Biology Letters 2023 28:4
    Content type: Research Published on:

  10. Authors: Junqiang Li, Yang Song, Chao Zhang, Ronglin Wang, Lei Hua, Yongdong Guo, Dongxue Gan, Liaoliao Zhu, Shanshan Li, Peixiang Ma, Cheng Yang, Hong Li, Jing Yang, Jingjie Shi, Xiaonan Liu and Haichuan Su
    Citation: Cellular & Molecular Biology Letters 2023 28:3
    Content type: Correction Published on:

    The original article was published in Cellular & Molecular Biology Letters 2022 27:24

  11. Hematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dysfunction. While much emphasis is on the reconstitution of hematopoietic stem cells in t...

    Authors: Seyram Yao Adzraku, Guozhang Wang, Can Cao, Yurong Bao, Yizhou Wang, Alhaji Osman Smith, Yuwei Du, Haiyang Wang, Yue Li, Kailin Xu, Jianlin Qiao, Wen Ju and Lingyu Zeng
    Citation: Cellular & Molecular Biology Letters 2023 28:2
    Content type: Research Letter Published on:

  12. Spatial chromatin structure is intricately linked with somatic aberrations, and somatic mutations of various cancer-related genes, termed co-mutations (CoMuts), occur in certain patterns during cancer initiati...

    Authors: Linlin Zhang, Miaomiao Xu, Wanchun Zhang, Chuanying Zhu, Zhilei Cui, Hongliang Fu, Yufei Ma, Shuo Huang, Jian Cui, Sheng Liang, Lei Huang and Hui Wang
    Citation: Cellular & Molecular Biology Letters 2023 28:1
    Content type: Research Published on:

  14. Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway. Here we performed a yeast two-hybrid screen using t...

    Authors: Yan Jia, Jianing Zhao, Tao Yu, Xue Zhang, Xiaozhen Qi, Tongxin Hao, Zeyuan Jin and Xiaoqing Zhao
    Citation: Cellular & Molecular Biology Letters 2022 27:111
    Content type: Research Published on:

  15. Metabolic disorder is considered a well-established risk factor for endometrial carcinoma (EC). However, the mechanism remains unclear. Insulin resistance and excessive flux of free fatty acids serve as fundam...

    Authors: Jingyi Zhou, Yanying Lin, Xiao Yang, Boqiang Shen, Juan Hao, Jiaqi Wang and Jianliu Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:110
    Content type: Research Letter Published on:

  16. The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angio...

    Authors: Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn and Rafal Bartoszewski
    Citation: Cellular & Molecular Biology Letters 2022 27:109
    Content type: Research Published on:

  17. Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognizes double-stranded DNA. AIM2 exhibits limited expression under physiological conditions ...

    Authors: Jianan Zhao, Shicheng Guo, Steven J. Schrodi and Dongyi He
    Citation: Cellular & Molecular Biology Letters 2022 27:108
    Content type: Review Letter Published on:

  18. Oral squamous cell carcinoma (OSCC) is a common head and neck cancer, and the incidence of OSCC is increasing. As the mortality of OSCC keeps increasing, it is crucial to clarify its pathogenesis and develop n...

    Authors: Xinyu Zhang, Yong Han, Shuli Liu, Bing Guo, Shengming Xu, Yue He and Liu Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:107
    Content type: Research Published on:

  19. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. CircFUT8 has been shown to be upregulated in cancers, but its function in HCC remains unclear. Tumor-associated macrophages (TAMs) are on...

    Authors: Liyan Wang, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng, Lei Ma and Bin Li
    Citation: Cellular & Molecular Biology Letters 2022 27:106
    Content type: Research Published on:

  20. Pyrimidine metabolism is critical for tumour progression. Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits ...

    Authors: Dehai Wu, Congyi Zhang, Guanqun Liao, Kaiming Leng, Bowen Dong, Yang Yu, Huilin Tai, Lining Huang, Feng Luo, Bin Zhang, Tiexiang Zhan, Qiuhui Hu and Sheng Tai
    Citation: Cellular & Molecular Biology Letters 2022 27:105
    Content type: Research Published on:

  21. Pyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemia in brothers of Polish origin that are associated with a very rare mutation. Heterozygous de...

    Authors: Dżamila M. Bogusławska, Michał Skulski, Rafał Bartoszewski, Beata Machnicka, Elżbieta Heger, Kazimierz Kuliczkowski and Aleksander F. Sikorski
    Citation: Cellular & Molecular Biology Letters 2022 27:104
    Content type: Research Published on:

  22. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the ro...

    Authors: Tahseen S. Sayed, Zaid H. Maayah, Heba A. Zeidan, Abdelali Agouni and Hesham M. Korashy
    Citation: Cellular & Molecular Biology Letters 2022 27:103
    Content type: Review Published on:

  23. The innate immune system is the body’s first line of defense against pathogens and involves antibody and complement system-mediated antigen removal. Immune-response-related complement molecules have been ident...

    Authors: Jiali Lu, Jinsong Duan, Yinglun Han, Meng Gou, Jun Li, Qingwei Li and Yue Pang
    Citation: Cellular & Molecular Biology Letters 2022 27:102
    Content type: Research Letter Published on:

  24. RNA N6-methyladenosine (m6A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulates spermatogenesis and androgen synthesis in an m6A-dependent manner. However, it is uncle...

    Authors: Zhonglin Cai, Yao Zhang, Lin Yang, Chunhui Ma, Yi Fei, Jing Ding, Wei Song, Wei-Min Tong, Yamei Niu and Hongjun Li
    Citation: Cellular & Molecular Biology Letters 2022 27:101
    Content type: Research Letter Published on:

  25. Metformin is an inhibitor of oxidative phosphorylation that displays an array of anticancer activities. The interference of metformin with the activity of multi-drug resistance systems in cancer cells has been...

    Authors: Jessica Catapano, Marcin Luty, Tomasz Wróbel, Maciej Pudełek, Katarzyna Piwowarczyk, Sylwia Kędracka-Krok, Maciej Siedlar, Zbigniew Madeja and Jarosław Czyż
    Citation: Cellular & Molecular Biology Letters 2022 27:100
    Content type: Research Published on:

  26. tRNA-derived fragments (tRFs) are newly discovered noncoding RNAs and regulate tumor progression via diverse molecular mechanisms. However, the expression and biofunction of tRFs in gallbladder cancer (GBC) ha...

    Authors: Lu Zou, Yang Yang, Biyu Zhou, Weijian Li, Ke Liu, Guoqiang Li, Huijie Miao, Xiaoling Song, Jiahua Yang, Yajun Geng, Maolan Li, Runfa Bao and Yingbin Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:99
    Content type: Research Published on:

  27. Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be invol...

    Authors: Gaiping Wang, Anqi Chen, Yu Wu, Danlin Wang, Cuifang Chang and Guoying Yu
    Citation: Cellular & Molecular Biology Letters 2022 27:98
    Content type: Review Letter Published on:

  28. Endothelial cells (ECs) play an important role in angiogenesis and vascular reconstruction in the pathophysiology of ischemic stroke. Previous investigations have provided a profound cerebral vascular atlas un...

    Authors: Zhuohui Chen, Xiang Wang, Haiyue Wu, Yishu Fan, Zhouyi Yan, Chenxiao Lu, Hongfei Ouyang, Shiyu Zhang and Mengqi Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:97
    Content type: Research Published on:

  30. Cardiomyocyte injury is a common complication during cardiac surgery with cardiopulmonary bypass (CPB). Studies have shown that circulating small extracellular vesicles (sEVs) are involved in the pathological ...

    Authors: Ting Wu, Guoning Shi, Zhenhua Ji, Shu Wang, Lizhu Geng and Zhigang Guo
    Citation: Cellular & Molecular Biology Letters 2022 27:95
    Content type: Research Letter Published on:

  32. EVA1A (Eva-1 homolog A), a novel protein involved in autophagy and apoptosis, functions as a tumor suppressor in some human primary cancers, including hepatocellular carcinoma (HCC). While it is consistently d...

    Authors: Qian Xu, Zhaozhong Liao, Zunshuang Gong, Xiaokun Liu, Yuling Yang, Zhe Wang, Weiyan Yang, Lin Hou, Jiejie Yang, Junying Song, Wenjing Liu, Bin Wang, Junnan Hua, Mingyi Pu and Ning Li
    Citation: Cellular & Molecular Biology Letters 2022 27:93
    Content type: Research Published on:

  33. Hepatocellular carcinoma (HCC) is among the most common and malignant cancers with no effective therapeutic approaches. Echinacoside (ECH), a phenylethanoid glycoside isolated from Chinese herbal medicine, Cistan...

    Authors: Menghan Wang, Xing Ma, Guoyu Wang, Yanan Song, Miao Zhang, Zhongchao Mai, Borong Zhou, Ying Ye and Wei Xia
    Citation: Cellular & Molecular Biology Letters 2022 27:92
    Content type: Research Published on:

  34. Long non-coding RNAs (lncRNAs) are critical regulators in lung adenocarcinoma (LUAD). M2-type tumor-associated macrophages (TAMs) also play oncogenic roles in LUAD. However, the involvement of lncRNAs in TAM a...

    Authors: Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang and Chang-li Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:91
    Content type: Research Published on:

  35. E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic co...

    Authors: Zejun Fang, Min Lin, Shenghui Chen, Hong Liu, Minjing Zhu, Yanyan Hu, Shanshan Han, Yizhang Wang, Long Sun, Fengjiao Zhu, Chengfu Xu and Chaoju Gong
    Citation: Cellular & Molecular Biology Letters 2022 27:90
    Content type: Research Published on:

  36. Numerous studies have revealed that long noncoding RNAs (lncRNAs) are closely related to the development of many diseases and carcinogenesis. However, their specific biological function and molecular mechanism...

    Authors: Lihua Ren, Xin Fang, Sachin Mulmi Shrestha, Qinghua Ji, Hui Ye, Yan Liang, Yang Liu, Yadong Feng, Jingwu Dong and Ruihua Shi
    Citation: Cellular & Molecular Biology Letters 2022 27:89
    Content type: Research Published on:

  37. Current studies show that exosomal miRNAs become an important factor in cancer metastasis. Among the many miRNA studies, miR-7-5p has not been thoroughly investigated in breast cancer metastasis.

    Authors: Zhaoyi Liang, Lu Liu, Ruixia Gao, Chengchuan Che and Ge Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:88
    Content type: Research Letter Published on:

  38. Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with invasive and metastatic characteristics and poor prognosis. Intracellular protein homeostasis is associated with invasion and metastasis of pan...

    Authors: Peng Liu, Fuqiang Zu, Hui Chen, Xiaoli Yin and Xiaodong Tan
    Citation: Cellular & Molecular Biology Letters 2022 27:87
    Content type: Research Published on:

  39. Research on aging is growing as the elderly make up a greater share of the population, focusing on reversing and inhibiting the aging process. The exhaustion and senescence of stem cells are the fundamental dr...

    Authors: Wei V. Zheng, Wang Xu, Yaqin Li, Jie Qin, Tao Zhou, Dezhi Li, Yanwei Xu, Xianyi Cheng, Yu Xiong and Zaizhong Chen
    Citation: Cellular & Molecular Biology Letters 2022 27:86
    Content type: Research Published on:

  40. Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) ...

    Authors: Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo and Guokun Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:85
    Content type: Research Published on:

  41. Long noncoding RNAs are involved in epigenetic gene modification, including binding to the chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in gene expression regulation,...

    Authors: Ruiming Li, Xia Wang, Chunming Zhu and Kefeng Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:84
    Content type: Review Published on:

  42. Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migrat...

    Authors: Abdulwahab Teflischi Gharavi, Niloofar Asadi Hanjani, Elaheh Movahed and Mohammad Doroudian
    Citation: Cellular & Molecular Biology Letters 2022 27:83
    Content type: Review Letter Published on:

  43. Influenza-related acute lung injury (ALI) is a life-threatening condition that results mostly from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses. The methoxy flavonoid c...

    Authors: Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li and Beixian Zhou
    Citation: Cellular & Molecular Biology Letters 2022 27:82
    Content type: Research Published on:

  44. CDGSH iron sulfur domain 2 (CISD2) is an iron–sulfur protein with a [2Fe–2S] cluster, which is critical for cell proliferation and iron homeostasis. It has been demonstrated that aberrant expression of CISD2 i...

    Authors: Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang and Jing Du
    Citation: Cellular & Molecular Biology Letters 2022 27:81
    Content type: Research Letter Published on:

  45. Extensive inflammation of endothelial cells (ECs) facilitates atherosclerotic lesion formation. Circular RNA (circRNA) participates in atherosclerosis (AS)-related inflammation responses; however, whether and ...

    Authors: Min Zhang, Yiqian Zhu, Jie Zhu, Yi Xie, Ruihao Wu, JiaYin Zhong, Zhaohui Qiu and Li Jiang
    Citation: Cellular & Molecular Biology Letters 2022 27:80
    Content type: Research Published on:

  46. MicroRNAs (miRNAs) play crucial roles in the development of hepatocellular carcinoma (HCC). Hsa-microRNA-27b-3p (hsa-miR-27b) is involved in the formation and progression of various cancers, but its role and clin...

    Authors: Jingyuan Wen, Zhao Huang, Yi Wei, Lin Xue, Yufei Wang, Jingyu Liao, Junnan Liang, Xiaoping Chen, Liang Chu and Bixiang Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:79
    Content type: Research Published on:

  48. Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as ...

    Authors: Irene Lee-Rivera, Edith López and Ana María López-Colomé
    Citation: Cellular & Molecular Biology Letters 2022 27:77
    Content type: Review Letter Published on:

  49. Ulcerative colitis-associated colorectal cancer (UC-CRC) is an important complication of ulcerative colitis. Pou3f1 (POU class 3 homeobox 1) is a critical regulator for developmental events and cellular biolog...

    Authors: Yan Lin, Dongxu Wang, Hong Zhao, Dongyue Li, Xinning Li and Lianjie Lin
    Citation: Cellular & Molecular Biology Letters 2022 27:75
    Content type: Research Published on:

  50. Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered particles are naturally released into...

    Authors: Mohsen Karami Fath, Jalil Azami, Niloofar Jaafari, Mahsa Akbari Oryani, Nafiseh Jafari, Alireza Karim poor, Ali Azargoonjahromi, Mohsen Nabi-Afjadi, Zahra Payandeh, Hamidreza Zalpoor and Dariush Shanehbandi
    Citation: Cellular & Molecular Biology Letters 2022 27:74
    Content type: Review Published on:

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