Table 3 Plasmids using NAT regulating systems
Plasmid | The role of the antisense RNA |
|---|---|
ColE1 | An asRNA, termed RNA I, binds to the 5’ end of RNA II, triggering a conformational change that initiates inhibiting replication by preventing persistent hybrid formation. |
Another asRNA, Rcda, complementary to the Cer region of plasmid, is synthesized when synaptic complexes between Cer sites are formed. It inhibits division when the plasmid is in a multimeric state and at risk of being lost. | |
IncFII-Like | An asRNA blocks the translation of leader protein and causes inhibition of Rep protein synthesis. |
IncIu-IncB | An asRNA prevents the formation of an activator RNA pseudo knot. |
pT181 and pIP501 | Antisense RNA induces attenuation of transcription. |