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Table 1 Expression of survivin in SCCs. NC- no statistical correlation, IHC-immunohistochemistry, RT-PCR- reverse transcriptase, WB-western blotting

From: Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma

Type of SCC Methods and number of samples Correlation with survivin Reference
Clinicopathologic variables Prognosis Survival  
Oral and Oropharyngeal IHC, WB (49) Size, Nodal metastasis    [76]
IHC (78) Size, Aggressiveness, Invasion Poor prognosis [77]
IHC, RT-PCR, WB (110) Early expression, Predictive invasive carcinoma    [227]
IHC (13) Distant non-lymphatic metastasis    [75]
IHC, RT-PCR (71) NC Poor prognosis [78]
IHC, WB (50) Metastasis, Associated with Aurora B Poor prognosis [81]
IHC, RT-PCR (29) Early expression, Predictive invasive carcinoma, Correlated with p53 expression    [74]
PCR, WB 7,12-dimethylbenz[a]anthracene (DMBA) carcinogenesis    [80]
Meta-analysis (1040) Lymph node metastasis, Clinical stages Poor prognosis   [79]
Laryngeal IHC (68) Site, Correlated with p53 Poor prognosis [70]
IHC (86) Metastasis    [228]
IHC (102) Metastasis    [229]
Esophageal RT-PCR (51) Nodal status Poor prognosis [83]
RT-PCR (57) Metastasis Poor prognosis [84]
IHC (84)   Poor prognosis [86]
Meta-analysis (610) Lymph node Metastasis Poor prognosis [71]
Non-small cell lung cancer IHC (58), NC Poor prognosis [95]
IHC, RT-PCR (83) Early marker, Tumor stages    [91]
Meta-analysis (2703) Tumor stages Poor prognosis   [230]
RT-PCR (71) NC   [90]
IHC (102) Tumor size, Distant metastasis Poor prognosis [92]
RT-PCR (140) Tumor differentiation, Aggressiveness, Correlated with p53 mutation    [93]
Skin IHC, WB (89) Size, Nodal metastasis   [76]
IHC (47 different groups) Early marker, Disease progression    [105]
IHC (62 different groups) Keratinocytic neoplasms, Hyperproliferative lesions    [104]
Cervical IHC (17) NC    [231]
IHC, WB (53) Size, Lymphovascular invasion Poor prognosis   [111]
IHC (59) Size, Tumor grade, Clinical stages Poor prognosis   [112]
IHC (73) HPV    [114]
RT-PCR (50) Tumor stages, Correlated with bcl2    [109]
IHC (50) Clinical stages, CIN grade, Lymph node metastases, Correlated with p16INK4A Poor prognosis   [110]
IHC (49) Clinical stage, Tumor size, Lymph node metastasis, Correlated with PTEN Early diagnostic and poor prognosis   [232]