Table 1 Expression of survivin in SCCs. NC- no statistical correlation, IHC-immunohistochemistry, RT-PCR- reverse transcriptase, WB-western blotting
From: Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma
Type of SCC | Methods and number of samples | Correlation with survivin | Reference | ||
|---|---|---|---|---|---|
Clinicopathologic variables | Prognosis | Survival | Â | ||
Oral and Oropharyngeal | IHC, WB (49) | Size, Nodal metastasis | Â | Â | [76] |
IHC (78) | Size, Aggressiveness, Invasion | Poor prognosis | ↓ | [77] | |
IHC, RT-PCR, WB (110) | Early expression, Predictive invasive carcinoma | Â | Â | [227] | |
IHC (13) | Distant non-lymphatic metastasis | Â | Â | [75] | |
IHC, RT-PCR (71) | NC | Poor prognosis | ↓ | [78] | |
IHC, WB (50) | Metastasis, Associated with Aurora B | Poor prognosis | ↓ | [81] | |
IHC, RT-PCR (29) | Early expression, Predictive invasive carcinoma, Correlated with p53 expression | Â | Â | [74] | |
PCR, WB | 7,12-dimethylbenz[a]anthracene (DMBA) carcinogenesis | Â | Â | [80] | |
Meta-analysis (1040) | Lymph node metastasis, Clinical stages | Poor prognosis | Â | [79] | |
Laryngeal | IHC (68) | Site, Correlated with p53 | Poor prognosis | ↓ | [70] |
IHC (86) | Metastasis | Â | Â | [228] | |
IHC (102) | Metastasis | Â | Â | [229] | |
Esophageal | RT-PCR (51) | Nodal status | Poor prognosis | ↓ | [83] |
RT-PCR (57) | Metastasis | Poor prognosis | ↓ | [84] | |
IHC (84) |  | Poor prognosis | ↓ | [86] | |
Meta-analysis (610) | Lymph node Metastasis | Poor prognosis | ↓ | [71] | |
Non-small cell lung cancer | IHC (58), | NC | Poor prognosis | ↓ | [95] |
IHC, RT-PCR (83) | Early marker, Tumor stages | Â | Â | [91] | |
Meta-analysis (2703) | Tumor stages | Poor prognosis | Â | [230] | |
RT-PCR (71) | NC |  | ↓ | [90] | |
IHC (102) | Tumor size, Distant metastasis | Poor prognosis | ↓ | [92] | |
RT-PCR (140) | Tumor differentiation, Aggressiveness, Correlated with p53 mutation | Â | Â | [93] | |
Skin | IHC, WB (89) | Size, Nodal metastasis |  | ↓ | [76] |
IHC (47 different groups) | Early marker, Disease progression | Â | Â | [105] | |
IHC (62 different groups) | Keratinocytic neoplasms, Hyperproliferative lesions | Â | Â | [104] | |
Cervical | IHC (17) | NC | Â | Â | [231] |
IHC, WB (53) | Size, Lymphovascular invasion | Poor prognosis | Â | [111] | |
IHC (59) | Size, Tumor grade, Clinical stages | Poor prognosis | Â | [112] | |
IHC (73) | HPV | Â | Â | [114] | |
RT-PCR (50) | Tumor stages, Correlated with bcl2 | Â | Â | [109] | |
IHC (50) | Clinical stages, CIN grade, Lymph node metastases, Correlated with p16INK4A | Poor prognosis | Â | [110] | |
IHC (49) | Clinical stage, Tumor size, Lymph node metastasis, Correlated with PTEN | Early diagnostic and poor prognosis | Â | [232] | |