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Table 4 Univariate analysis of OS and PFS in EOC patients

From: VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer

Variable Cases (N) Media of OS y 2 p Media of PFS y 2 p
Age    3.212 0.073   1.830 0.176
  ≤ 50 years 60 54    41   
  > 50 years 64 43    34  
Menopausal status    0.076 0.782   0.069 0.793
 Yes 78 48      
 No 46 51     
Pathologic type    0.354 0.552   0.002 0.967
 Serous carcinoma 80 43    41   
 Mucous and others 44 53    36  
Histologic grade    26.047 0.000   5.636 0.018
 G1–2 49 85    48   
 G3 or Undifferentiated 75 43    33  
FIGO Stage    32.221 0.000   11.370 0.001
 I–II 53 68    49   
 III–IV 71 39    33  
LN metastasis    17.484 0.000   12.361 0.000
 No 74 56    48   
 Yes 50 35    33  
Residual disease    24.872 0.000   5.824 0.016
  < 1 cm 94 54    41   
  ≥ 1 cm 30 35    33  
Patients’ response to chemotherapy    16.060 0.000   5.393 0.020
 CR 87 53    40   
 PR, SD and PD 37 32    34  
Tumor sensitivity to chemotherapy    10.502 0.001   13.085 0.000
 Platinum sensitive 92 53    45   
 Platinum resistant and refractory 32 22    10  
VEGF    29.685 0.000   1.945 0.163
 Negative 72 58    41   
 Positive 52 32    34  
SEMA4D    34.933 0.000   16.541 0.000
 Negative 48 NR    49   
 Positive 76 41    31  
  1. FIGO International Federation of Gynecology and Obstetrics, NR not reached, CR complete response, PR partial response, SD stable disease, PD progressive disease