Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population

Table 4 Distribution of APOE genotypes and allele frequencies according to aSAH subtypes

Variable	Case	ε 2/ ε2	P	ε 2/ ε3	P	ε 2/ ε4	P	ε 3/ ε3	P	ε 3/ ε4	P	ε 4/ ε4	P	ε 2 Vs ε3 (P)	ε 4 Vs ε3 (P)
Total	200	2		18		1		134		45		0
Site of Aneurysm
ACOM	86	0	0.62	7	0.86	1	0.69	57	0.89	21	0.78	0	0.69	0.61	0.57
PCOM	12	1	0.09	2	0.42	0	0.15	5	0.26	4	0.51	0	0.15	0.03	0.31
ICA	36	0	0.82	2	0.92	0	0.33	30	0.61	4	0.18	0	0.33	0.26	0.12
MCA	37	1	0.42	4	0.75	0	0.44	24	0.82	8	0.92	0	0.44	0.44	0.65
Multiple	22	0	0.71	3	0.53	0	0.29	13	0.73	6	0.81	0	0.29	0.74	0.65
Basilar top	7	0	0.29	0	0.82	0	0.11	5	0.91	2	0.69	0	0.11	0.69	0.81
Size of Aneurysm
Small (<15 mm)	159	1	0.70	14	0.95	1	0.87	109	0.89	34	0.83	0	0.89	0.81	0.81
Large (15-25 mm)	37	1	0.50	3	0.86	0	0.45	22	0.68	11	0.46	0	0.45	0.67	0.39
Giant (>25 mm)	4	0	0.17	1	037	0	0.06	3	0.88	0	0.95	0	0.06	0.50	0.61
WFNS Grade
Grade I	91	1	1	10	0.62	1	0.73	57	0.73	22	0.80	0	0.73	0.49	0.64
Grade II	42	0	0.99	6	0.35	0	0.42	30	0.80	5	0.20	0	0.42	0.68	0.16
Grade III	51	1	0.56	0	0.11	0	0.48	36	0.83	13	0.77	0	0.48	0.14	0.77
Grade IV	16	0	0.57	2	0.67	0	0.16	11	0.94	5	0.54	0	0.16	0.99	0.67
Male	77	1	0.50	10	0.37	1	0.62	51	0.95	14	0.52	0	0.62	0.27	0.62
Female	123	1	0.85	8	0.46	0	0.70	83	0.96	31	0.66	0	0.81	0.35	0.76
Hypertension (+)	109	1	0.94	9	0.83	0	0.75	74	0.94	25	0.94	0	0.75	0.71	0.96
Diabetes mellitus (+)	71	0	0.82	5	0.63	1	0.46	51	0.74	14	0.69	0	0.55	0.30	0.57
Alcohol (+)	57	1	0.64	10	0.11	1	0.37	33	0.54	12	0.85	0	0.55	0.04	0.85
Smoking (+)	58	0	0.80	8	0.34	1	0.38	38	0.92	11	0.64	0	0.52	0.44	0.78

ISSN: 1689-1392