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Table 2 Comparison of the IC50 values for HEp-2 and HEp-2/VCR cells exposed to 4 chemotherapeutics

From: C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

 

IC50/(μmol/l)

 

Anti-cancer drugs

  

Resistant fold

 

HEp-2

HEp-2/VCR

 

VCR

0.04 ± 0.01

1.7 ± 0.19

42.5

MTX

1.2 ± 0.35

8.3 ± 0.23

6.90

DDP

0.5 ± 0.25

1.9 ± 0.16

3.8

5-FU

61.1 ± 4.35

332 ± 5.21

5.44

  1. Data are shown as the means ± SD
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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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