Fig. 3From: STAT3, stem cells, cancer stem cells and p63STAT3 regulation. Multiple signals lead to phosphorylation of STAT3 at Tyr705 or Ser727, leading to dimerization, nuclear import and transcriptional activation. SOCS proteins, phosphatases and PIAS proteins inhibit STAT3 activity at different stages of STAT3 activation. Other modifications including ubiquitination, acetylation and methylation may also occurBack to article page