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Table 1 Norpurpureine prevents ADP-induced platelet adhesion onto fixed fibrinogen

From: The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro

  Net Adhesion (AU) Platelet-specific adhesion (PSA) to Fg induced by ADP PSA (%) vs. vehicle
ADP (−) ADP (+)
Vehicle 0.39 (0.04) 0.95 (0.05) 0.56 (0.05) 100.00 (4.7)
Norp 220 μM 0.42 (0.03) 0.51 (0.04) 0.09 (0.01) 16.07 (1.8)***
Norp 90 μM 0.41 (0.02) 0.73 (0.04) 0.32 (0.02) 56.55 (3.7)***
Norp 30 μM 0.42 (0.03) 0.85 (0.02) 0.43 (0.03) 76.78 (4.7)**
Apyrase 0.40 (0.02) 0.49 (0.03) 0.09 (0.02) 16.67 (2.7)***
  1. Platelets in PRP (1 × 105) were pretreated with vehicle (DMSO 0.25%), apyrase (0.5 U/ml) or norpurpureine (Norp) at the indicated concentrations for 10 min before the addition of 10 μM ADP to test their adhesion onto fixed fibrinogen (Fg). The values are the means ± SD (n = 3, done in triplicate) p < 0.01 (**) and p < 0.001 (***) compare to vehicle.