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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes

Fig. 3

In MLO-Y4 osteocytes, miR-29b-3p was one of the ten mechanoresponsive miRs which were confirmed by RT-qPCR. a Based on microarray assay of miRs, the result of RT-qPCR showed that ten miRs were responsive to the mechanical tensile strain, and miR-29b-3p was one of the ten miRs (n = 5). b The miR-29b-3p mimic elevated miR-29b-3p level of osteocyte and the miR -29b-3p inhibitor decreased the miR level (n = 5). c In MC3T3-E1 osteoblastic cells, the mechanical tensile strain did not change the expression of miR-29b-3p, which was demonstrated with microarray and RT-qPCR. Contrarily, in MLO-Y4 osteocytes, the mechanical strain decreased miR-29b-3p expression (n = 5). *P < 0.05 and **P < 0.01, compared with the unstrained control group, or between the indicated groups

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