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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway

Fig. 6

HO-1 is a direct target of miR-218-5p. The conserved binding sites between miR-218-5p and HO-1 were predicted using online software TargetScan and miRDB (a), and the luciferase activity assay was performed to validate HO-1 as a direct target of miR-218-5p (b). After transfection with miR-218-5p mimics into GMCs, the mRNA (c) and protein (d) expression levels of HO-1 were measured by RT-qPCR and western blotting, respectively. Values are expressed as mean ± SEM, n = 3 in each group. * P < 0.05 versus control group

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