Fig. 4

EIF4A2 is a direct target of miR-5195-3p. a The binding sites of EIF4A2 and miR-5195-3p were predicted using bioinformatics analysis. b and c The luciferase reporter assay was performed in paclitaxel-resistant BT549/PTX and MDA-MB-231/PTX cells. d and e Quantitative real-time PCR and western blot assays were used to analyze the expression of EIF4A2 after transfection of miR-5195-3p mimics and miR-NC. f The expression of EIF4A2 was determined via quantitative real-time PCR in 18 paclitaxel-sensitive and 18 paclitaxel-resistant tissues. g Spearman rank correlation analysis showed an inverse correlations between the expression levels of EIF4A2 and miR-5195-3p in paclitaxel-resistant breast cancer tissues. **p < 0.01 vs. miR-NC