Downregulation of miR-637 promotes vascular smooth muscle cell proliferation and migration via regulation of insulin-like growth factor-2

Table 2 The effect of miR-637 on blood lipids in ApoE knockout mice (\( \overline{\mathrm{x}}\kern0.5em \pm \kern0.5em \mathrm{s} \))

Group	AG-NC	AG	AN-NC	AN
Body weight (g)	26.48 ± 2.54	28.37 ± 2.88	27.52 ± 2.33	28.12 ± 2.42
TG (mmol/l)	2.46 ± 0.55	1.86 ± 0.52^&	2.42 ± 0.62	3.82 ± 0.62***
TC (mmol/l)	14.78 ± 2.96	11.34 ± 2.21^&&	15.32 ± 2.89	17.11 ± 3.82*
HDL-C (mmol/l)	3.44 ± 0.87	5.12 ± 0.95^&&&	3.47 ± 0.78	2.35 ± 0.89*
LDL-C (mmol/l)	12.01 ± 1.12	10.12 ± 1.08^&&	11.90 ± 1.32	14.78 ± 2.76**

n = 10; AG-NC miR-637 agomir negative control; AG miR-637 agomir, AN-NC miR-637 antagomir negative control, AN miR-637 antagomir, TG Triglyceride, TC Total cholesterol, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol
^&, ^&& and ^&&&& respectively indicate p < 0.05, p < 0.01 and p < 0.001
*, ** and *** respectively indicate p < 0.05, p < 0.01 and p < 0.001

ISSN: 1689-1392