Fig. 2

Iron overload (an effect of thalassemia major) affects patients’ bone marrow mononuclear cells. a, b—The cell viability (a) and proliferation activity (b) of mononuclear cells in the bone marrow of the patients both decreased. c through f—LC3 levels (c) and mROS levels (d) increased, and SOD2 (e) and SIRT3 (f) activity decreased in the BMMNCs from the patients (n = 6).The results are expressed as a percentage of the control group, which is set at 100%. The values are presented as the means ± SEM, **p < 0.05 vs. the control group