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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Deficiency of αII-spectrin affects endothelial cell–matrix contact and migration leading to impairment of angiogenesis in vitro

Fig. 5

Knockdown of αII-spectrin alters the expression and localization of some integrins. a and b HMEC-1 cells were labelled 72 h after transfection with either Nr siRNA or Sp siRNA with polyclonal antibodies (red) directed against α5-integrin (a) and αVβ3-integrin (b). Spectrin and actin were labelled green. In Sp siRNA-treated cells, α5-integrin distribution is modified (present as aggregates) and αVβ3-integrin does not accumulate in focal points and forms aggregates in the cytoplasm. Depletion of spectrin is also associated with decreased expression of these integrins. Scale bar = 20 μm

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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