Fig. 4
From: Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis
CERNA, MUNC, and DRReRNA associate with MyoD and MyoG in cis and trans during myogenesis. MyoD expression is induced by the TFs FoxO3, Six1/4, and Pax3 and Pax7 and regulated by CERNA in cis. However, DRReRNA in trans via interacting with cohesin complex activates MyoG. MUNC via a heterologous promoter in trans promotes endogenous gene expression of MyoD, myogenin, and Myh3. bHLH protein MyoR binds E-proteins directly on MyoD target DNA sequences hence repressing its activities